Vitamin D pathway gene polymorphisms influenced vitamin D level among pregnant women

Shao, Bule; Jiang, Shuying; Muyiduli, Xiamusiye; Wang, Shuojia; Mo, Minjia; Li, Minchao; Wang, Zhaopin; Yu, Yunxian

doi:10.1016/j.clnu.2017.10.024

Cited by 58 publications

(71 citation statements)

References 47 publications

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“…Previous studies investigating the association of GC rs7041 with 25OHD had demonstrated C allele associated with decreased risk of VDD in pregnant [25][26][27]50] and non-pregnant population [19][20][21][22]. In contrast to the previous studies, the C allele was found to increase the risk of VDD in pregnant women in the current study.…”

Section: Discussioncontrasting

confidence: 99%

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Lee

Ling

Tusimin³

et al. 2020

Preprint

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Background Vitamin D deficiency (VDD) has been related to vitamin D binding protein (GC) gene polymorphism, demographics and lifestyle factors in different populations. However, previous studies examining the factors associated with VDD during pregnancy were restricted to the study of only demographics and lifestyle factors or genetic factors alone. Thus, this study assesses the associations of GC gene polymorphism, environmental and lifestyle factors with VDD in Malaysian pregnant women. Method: Information on demographics, dietary vitamin D intake from supplement and food, time spent outdoors, skin type and clothing were collected by questionnaire. Plasma total 25-hydroxyvitamin D (25OHD) levels were measured using Ultra-High-Performance Chromatography (UHPLC). Maternal GC single nucleotide polymorphisms (SNPs) (rs4588 and rs7041) were determined using restriction fragment length polymorphism (RFLP). Results Results showed that 50.2% of pregnant women were vitamin D deficient (25OHD < 30 nmol/L). VDD (25OHD < 30 nmol/L) were significantly associated with age, veiled clothing, maternal vitamin D intakes, both from food and supplement, and GC rs7041(and GC diplotypes). In contrast to previous studies in non-pregnant population, this study found that CC genotype for SNP GC rs7041, GC 1 s-1 s and GC If-2 were significantly associated with increased risk of VDD (25OHD < 30 nmol/L). Conclusions The high prevalence of maternal VDD reported in the present study suggests the need for urgent development and implementation of vitamin D supplementation or fortification strategies to reduce VDD among pregnant women. The discrepancy in the association of GC rs7041 with VDD reflects the differential in the factors associated with vitamin D deficiency in pregnancy compared to non-pregnant state

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Section: Discussioncontrasting

confidence: 99%

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Lee

Ling

Tusimin³

et al. 2020

Preprint

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“…Before performing any genotyping we run a power analysis based on (1) the observed distribution of f-25OHD in the present population [13] and the published literature on a vitamin D depleted population [16] with standard deviations (SD) of 8 to 10 ng/ml and (2) differences in f-25OHD found between some of the genotypes investigated by us (2.5 to 4 ng/ml) [16]. Given an SD of 10 ng/ml and an alpha level of 0.05 we had 80% power to detect a difference in f-25OHD levels from 2.7 to 6 ng/ml at different frequencies of the minor allele (50 to 5%, respectively).…”

Section: Discussionmentioning

confidence: 99%

Impact of genetic influence on serum total- and free 25-hydroxyvitamin-D in humans

Szili

Szabo

Horváth

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

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Serum 25-hydroxyvitamin D /25OHD/ levels in humans are determined primarily by environmental factors such as UV-B radiation and diet, including vitamin D intake. Although some genetic determinants of 25OHD levels have been shown, the magnitude of this association has not yet been clarified. The present study evaluates the genetic contribution to total- /t-25OHD/ and free-25OHD /f-25OHD/ in a representative sample of the Hungarian population (n = 462). The study was performed at the end of winter to minimize the effect of sunlight, which is a major determinant of serum vitamin D levels. Single nucleotide polymorphisms (SNPs) of five genes playing major roles in vitamin D metabolism were investigated (NADSYN1, DHCR7, GC, CYP2R1 and CYP24A1). The selected SNPs account for 13.1% of the variance of t-25OHD levels. More than half of the genetic effect on t-25OHD levels was explained by two polymorphisms (rs7935125 in NADSYN1 and rs2762941 in CYP24A1), which had not previously been investigated with respect to vitamin D metabolism. No SNPs exhibited association with f-25OHD levels. Unexpectedly, SNPs that showed univariate associations with vitamin D binding protein (DBP) levels were not associated with f-25OHD levels questioning the biological significance of these polymorphisms. The present study shows that t-25OHD levels are significantly influenced by genetic factors, however, the clinical significance of this observation remains to be defined, as variation in f-25OHD levels are marginally explained by genetic effects.

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“…Liver contains both CYP27A1 and CYP2R1 and participates in the conversion of cholecalciferol (vitamin D 3 ) to 25-hydroxy-vitamin D. The population studies have also shown a link between CYP2R1, GC (VDBP), CYP24A1, and VDR with that of circulating 25(OH)VD concentrations. Recent studies have shown a regulatory role of CYP27A1 gene expression on the blood concentrations of 25(OH)VD ( 4 , 54 , 57 , 62 , 63 ).…”

Section: Methodsmentioning

confidence: 99%

Glutathione Stimulates Vitamin D Regulatory and Glucose-Metabolism Genes, Lowers Oxidative Stress and Inflammation, and Increases 25-Hydroxy-Vitamin D Levels in Blood: A Novel Approach to Treat 25-Hydroxyvitamin D Deficiency

Jain

Parsanathan

Achari

et al. 2018

Antioxidants & Redox Signaling

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Aims: 25-Hydroxyvitamin D [25(OH)VD] deficiency/inadequacy is a major public health issue affecting more than 1 billion people worldwide. A convincing association exists between low levels of circulating 25(OH)VD and the poor health outcomes associated with chronic diseases. However, high supraphysiological doses of VD are needed to achieve the required 25(OH)VD levels in the blood, because many subjects respond poorly to supplementation.Results: This study reports a link between 25(OH)VD deficiency and a reduction in glutathione (GSH) in obese adolescents. The improvement in GSH status that results from cosupplementation with VD and l-cysteine (LC; a GSH precursor) significantly reduced oxidative stress in a mouse model of 25(OH)VD deficiency. It also positively upregulated VD regulatory genes (VDBP/VD-25-hydroxylase/VDR) in the liver and glucose metabolism genes (PGC-1α/VDR/GLUT-4) in muscle, boosted 25(OH)VD, and reduced inflammation and insulin resistance (IR) levels in the blood compared with supplementation with VD alone. In vitro GSH deficiency caused increased oxidative stress and downregulation of VDBP/VD-25-hydroxylase/VDR and upregulation of CYP24a1 in hepatocytes and downregulation of PGC-1α/VDR/GLUT-4 in myotubes. This study demonstrates that improvement in the GSH status exerts beneficial effects on the blood levels of 25(OH)VD, as well as on the inflammation and IR in a VD-deficient mouse model. Thus, the VD supplements widely consumed by the public are unlikely to be successful unless the GSH status is also corrected.Innovation: These studies demonstrate a previously undiscovered mechanism by which GSH status positively upregulates the bioavailability of 25(OH)VD.Conclusion: Supplementation with a combination of VD and LC or GSH precursor, rather than supplementation with VD alone, is beneficial and helps achieve more successful VD supplementation.

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Vitamin D pathway gene polymorphisms influenced vitamin D level among pregnant women

Cited by 58 publications

References 47 publications

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Impact of genetic influence on serum total- and free 25-hydroxyvitamin-D in humans

Glutathione Stimulates Vitamin D Regulatory and Glucose-Metabolism Genes, Lowers Oxidative Stress and Inflammation, and Increases 25-Hydroxy-Vitamin D Levels in Blood: A Novel Approach to Treat 25-Hydroxyvitamin D Deficiency

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