Vitamin D receptor gene polymorphism is associated with chronic periodontitis

Tachi, Yoichi; Shimpuku, Hitomi; Nosaka, Yasuhiro; Kawamura, Tatsuro; Shinohara, Mitsuko; Ueda, Mitsuharu; Imai, Hisao; Ohura, Kiyoshi

doi:10.1016/j.lfs.2003.03.001

Cited by 78 publications

(82 citation statements)

References 35 publications

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“…In particular, the TT genotype and the presence of T allele are associated with chronic periodontal disease in Japanese, Chinese and Caucasian subjects (23)(24)(25)(26)(27). This data is also in accordance with our previous study which showed a strong correlation between TT genotype of Italian subjects and chronic periodontitis (OR 3.59) but also with aggressive periodontal disease (28).…”

Section: Taqisupporting

confidence: 91%

Vitamin D: relevance in dental practice

Martelli¹

2014

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SummaryObjective. The potential role of VDR gene variations in modulating periodontal susceptibility have been a subject of scientific investigations. The aim of this paper is to perform a literature review of the potential correlation between Vitamin D Receptor (VDR) gene polymorphisms and periodontal disease. Materials and methods. A PubMed literature search was made using "vitamin d receptor polymorphisms periodontal disease" as keys words. Only clinical studies in "Humans" as species and "English" as language were considered. Titles and abstracts of all identified records were examined to determine if the candidate articles contained sufficient information on the association of the VDR polymorphisms and the risk of development periodontal disease. Conclusions. Vitamin D may affect the risk of developing periodontal disease via an effect on bone mineral density or via immunomodulatory effects. There are scientific evidences about the correlation between some VDR polymorphisms, periodontitis and bone metabolism. The use of new simple and economics diagnostic techniques of genetic screening, allows to the dental specialists to identify periodontal patients with possible decreased bone mineral density. The complete acquisition of awareness by dentists of the strong relationship between skeletal bone density with periodontal health and osteointegrated implant success, could open a new therapeutic approach for periodontists with an important role in the early detection of osteoporosis and a better patient compliance of the periodontal therapy.

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Section: Taqisupporting

confidence: 91%

Vitamin D: relevance in dental practice

Martelli¹

2014

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“…An Abf haplotype containing rs2228570 has been reported to confer an elevated risk of severe CP in Japanese men (Naito et al, 2007), while several other studies found no significant association between rs2228570 and CP susceptibility (Tachi et al, 2003;Wang et al, 2009;Chen et al, 2012;Tanaka et al, 2013). No significant association was found in a previous meta-analysis of 15 studies including 1338 cases and 1302 controls between rs2228570 and CP (Chen et al, 2012).…”

Section: Discussionmentioning

confidence: 90%

Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population

Wang

Chen

2015

Genet. Mol. Res.

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ABSTRACT. The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 controls. Genomic DNA was extracted from buccal epithelial cells and genotyped using matrix-assisted laser desorption/ ionization time-of-flight-mass spectrometry. No significant difference in allelic or genotypic frequencies distributions for rs2228570 was found between CP patients and controls. In conclusion, we found no statistically significant association between rs2228570 and CP in our population.

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“…On the contrary, Li et al (2008) reported that F allele increased the susceptibility of aggressive periodontitis in Chinese (Li et al, 2008) and Park, Nam, and Choi (2006) reported that CC genotype associated with increased risk for generalized aggressive periodontitis in Koreans (Park et al, 2006). However, several studies have also reported no association between rs2228570 and periodontis (Wang, Zhang, & Chen, 2015; Wang et al, 2009; El Jilani et al, 2015; Tachi et al, 2003). …”

Section: Discussionmentioning

confidence: 99%

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Heikkinen

Kettunen

Kovanen

et al. 2016

Clinical & Exp Dental Res

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Several studies have addressed cytokine gene polymorphisms and their possible associations with periodontitis. We examined the association between salivary anti‐ and pro‐inflammatory mediator polymorphisms and initial periodontitis in Finnish adolescents, taking into account the effect of smoking. Salivary samples of 93 clinically examined adolescents from Eastern Finland were analyzed. Their oral health and smoking habits were recorded. Periodontal probing depth (PPD), and bleeding on probing (BOP) at four sites per tooth, root calculus (RC), and visible plaque index (VPI) were recorded from the index teeth. Salivary MMP‐8 median values were assessed. The sites with ≥4 mm PD were categorized as follows: PPD1 = one or more ≥4 mm pocket, PPD2 = two or more ≥4 mm pockets, and PPD3 = three or more ≥4 mm pockets. Genomic DNA was extracted from 300 μl of the saliva samples by genomic QIAamp® DNA Blood Mini Kit and genotyped for polymorphisms. Genetic variants for genotyping were selected from the following genes of interest: S100A8, FCGR2A, FCGR2B, IL10, MMP8, MMP3, MMP13, VDR, TLR4, MMP2, MPO, ELANE, IL1A, IL1B, IL1RN, CD28, MMP9, DDX39B, NFKBIL1, LTA, TNF, SOD2, IL6, TLR4, TIMP1, and SYN1. After false discovery rate control (FDR), polymorphisms in MMP3 (rs679620, rs520540, rs639752), CD28 (rs3116496), and VDR (rs2228570) associated (FDR q < 0.05) with deepened periodontal pockets. Smoking did not affect the results. Genetic polymorphisms of pro‐inflammatory mediators MMP3, CD28, and VDR seem to link to initial periodontitis.

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Vitamin D receptor gene polymorphism is associated with chronic periodontitis

Cited by 78 publications

References 35 publications

Vitamin D: relevance in dental practice

Vitamin D: relevance in dental practice

Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

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