Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians.

Hitman, G. A.; Mannan, Nasima; McDermott, Michael F.; Aganna, Ebun; Ogunkolade, B; Hales, C. N.; Boucher, Barbara J.

doi:10.2337/diabetes.47.4.688

Cited by 122 publications

(104 citation statements)

References 7 publications

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“…[220][221][222] Vitamin D has important immunomodulatory properties 223 and depletion or relative resistance may play a part in the aetiology of both T1DM and T2DM, possibly through effects on insulin secretion. 224 It has been shown that allelic variations in the vitamin D receptor (VDR) gene is a significant determinant of the amount of VDR mRNA and VDR protein expressed, 225 and may also affect plasma concentrations of 1,25(OH) 2 D 3 , and the response to oral vitamin D. 226 An association between VDR polymorphisms and T1DM has been reported in South Indian, German and Taiwanese populations, [227][228][229] although not necessarily with the same VDR polymorphisms.…”

Section: Iddm2-the Insulin Gene (Ins) Regionmentioning

confidence: 99%

Genetics of type 1 diabetes mellitus

2002

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Section: Iddm2-the Insulin Gene (Ins) Regionmentioning

confidence: 99%

Genetics of type 1 diabetes mellitus

2002

Self Cite

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“…Based on the effect of the VDR ligand on immune function, an association between type 1 DM and VDR polymorphisms is likely. The effect of VDR polymorphisms on insulin secretion has been reported before [15]. Four major polymorphic sites have been described within the VDR gene.…”

Section: Vitamin D Receptor Gene Polymorphisms In Type 1 Diabetes Melmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms in type 1 diabetes mellitus: a new pattern from Khorasan province, Islamic Republic of Iran

Bonakdaran¹,

Mr²,

Dadkhah³

et al. 2012

East Mediterr Health J

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Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. We studied the association between type 1 diabetes and 4 VDR gene polymorphisms (Bb, Ff, Aa and Tt) in an Iranian population. A group of 69 patients with type 1 diabetes mellitus and 45 unrelated healthy subjects were recruited. The prevalence of VDR polymorphisms in 4 restriction fragment length polymorphism sites including BsmI, FokI, ApaI and TaqI were analysed in patients and controls. The frequencies of 3 genotypes (Aa, FF and Bb) were significantly higher in the patient group. The relationship between VDR gene polymorphisms and onset pattern of diabetes was not significant. There were no significant difference between the genotype frequencies and chronic complications of diabetes, but the relationship between the Ff genotype and ketoacidosis was significant. Our results differ from previous polymorphism studies in other regions.

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“…A study in Bangladeshi Asians demonstrated that the ApaI RFLP influences insulin secretion in response to glucose [33], while associations between the VDR ApaI RFLP and higher fasting plasma glucose levels and glucose intolerance were observed in a community-based study of older adults without known diabetes [34]. More recently, genotyping for TaqI, ApaI, BsmI and FokI RFLPs revealed that the BsmI RFLP is associated with high fasting glucose levels in young males with low physical activity [35].…”

Section: Vitamin D and Type 2 Diabetesmentioning

confidence: 99%

Vitamin D and diabetes

et al. 2005

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Vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes, and receptors for its activated form-1α,25-dihydroxyvitamin D 3 -have been identified in both beta cells and immune cells. Vitamin D deficiency has been shown to impair insulin synthesis and secretion in humans and in animal models of diabetes, suggesting a role in the development of type 2 diabetes. Furthermore, epidemiological studies suggest a link between vitamin D deficiency in early life and the later onset of type 1 diabetes. In some populations, type 1 diabetes is associated with certain polymorphisms within the vitamin D receptor gene. In studies in nonobese diabetic mice, pharmacological doses of 1α,25-dihydroxyvitamin D 3 , or its structural analogues, have been shown to delay the onset of diabetes, mainly through immune modulation. Vitamin D deficiency may, therefore, be involved in the pathogenesis of both forms of diabetes, and a better understanding of the mechanisms involved could lead to the development of preventive strategies.

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Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians.

Cited by 122 publications

References 7 publications

Genetics of type 1 diabetes mellitus

Genetics of type 1 diabetes mellitus

Vitamin D receptor gene polymorphisms in type 1 diabetes mellitus: a new pattern from Khorasan province, Islamic Republic of Iran

Vitamin D and diabetes

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