Vitamin D Receptor Gene Polymorphisms and Risk of Atopic Dermatitis in Chinese Han Population

Abstract

Background: Studies investigated the associations between four Vitamin D receptor (VDR) common variations and interactions of gene-environment factors and atopic dermatitis (AD) in Chinese population are few. Methods: In this case-control study, 400 AD patients and 400 controls were genotyped for the FokI, TaqI, BsmI and ApalI variations of VDR genes by restriction fragment length polymorphism analysis. The associations between VDR genes and AD were assessed by univariate and multivariate logistic regression. The interactions between VDR genes and some risk factors were also explored using cross-over analysis. The corresponding odds ratio (ORs) and 95% confidence intervals (CI) were also calculated. Results: The FoKI rs2228570 polymorphism was significantly associated with an increased risk of atopic dermatitis in the co-dominant model (OR=2.93, 95% CI: 1.78-4.82. P=0.000), recessive model (OR=2.67, 95% CI: 1.68-4.26, P=0.000) and dominant model (OR=1.38, 95% CI: 1.04-1.84, P=0.028), and allele model. No significant associations were found among TaqI, BsmI and ApalI polymorphism and AD. The C-A-T-C and C-G-T-T haplotypes significantly increased the risk of atopic dermatitis. For rs2228570, the increased effects were more evident in the subgroups of age ≤8-month, cow milk and mixed, and keeping pet. Interactions between rs2228570 gene polymorphism and family history, age >8, and keeping pet increased the AD risk. The rs2228570 C allele decreased the relative mRNA expression. Conclusion:The FokI rs2228570 C allele of VDR gene could be a risk candidate gene for AD. Interactions between FokI polymorphism and family history and some behaviors may increase the risk of AD.

The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy

“…Several publications have reported associations between VDR gene polymorphisms, such as rs1544410 or rs2228570, and decreased vitamin D levels [33][34][35]. Additionally, rs2228570 has been associated with an increased risk of atopic dermatitis or allergic asthma in some studies [9,36,37]. A recent report even showed that the rs2228570 A allele increased the risk of allergic rhinitis [38].The results of our study support that the rs2228570 allele A is associated with decreased vitamin D levels in both patients with atopy and healthy subjects.…”

“…Studies have shown that VDR gene polymorphisms, such as rs7975232, rs1544410, and rs731236, may confer susceptibility to allergic diseases in certain populations [7]. Furthermore, several studies have demonstrated a significant association between VDR gene polymorphisms and asthma risk [8], or have indicated that rs2228570 could be associated with the risk of atopic dermatitis [9]. On the other hand, there is controversial data from various studies regarding the association of VDR SNPs with atopic conditions [10].…”

The relationship between single nucleotide polymorphisms and skin cancer susceptibility: A systematic review and network meta-analysis

“…This metabolite is the ligand of the VDR, which in turn initiates a series of biological responses in bone metabolism, immunity, cell proliferation, and differentiation by binding to vitamin D response elements in DNA ( 79 ). Hence, rs2228570 has not only been associated with various skin diseases, such as chronic spontaneous urticaria (CSU) ( 80 ), atopic dermatitis (AD) ( 81 ), and leprosy ( 82 ), but has also been linked to an increased incidence risk and worse prognosis of different cancers, such as breast cancer ( 83 ), ovarian cancer ( 84 ), gastric cancer ( 85 ), hepatocellular carcinoma ( 86 ), papillary thyroid cancer ( 87 ), pancreatic cancer ( 88 ), and melanoma. Our results are consistent with previous studies using assay methods ( 89 ).…”

Distribution of Alleles and Genotypes of VDR Gene in Children with Allergic Diseases

“…Несмотря на то, что уровень этого метаболита не достигал значений дефицита (<20 ng/ml), полученные результаты можно использовать для подбора индивидуальных доз витамина D при обязательном мониторинге концентрации данного метаболита. Исследования взаимосвязи концентрации 25-OH витамина D с вариантами полиморфизма гена VDR проводились различными авторами [15,16]. В частности, 11-летнее наблюдение за пациентами с низким уровнем 25-OH витамина D при однонуклеотидных заменах в гене VDR выявило их связь с развитием инфарктов, онкологических заболеваний и переломами шейки бедра.…”