Vitamin D receptor gene polymorphisms characteristic

Protas, Valeria; Pogossyan, Gayane; Li, Konstantin; Danilenko, Michael

doi:10.31489/2021bmg4/60-70

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Previously, in review article, we compared rs2228570 frequency alleles and genotypes submitted in dbSNP NCBI (National Center for Biotechnology Information, USA) with data published in peer-reviewed publications [15]. It was found that rs2228570 is four-allelic, with a predominance of G (0.611257) and A (0.388743) alleles [16].…”

Section: Resultsmentioning

confidence: 99%

Frequency of rs2228570 single nucleotide polymorphism of Vitamin-D Receptor (VDR) gene among the Kazakh ethnic group

Protas¹,

Pogossyan²,

Li³

et al. 2023

BMG

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The article presents the results of the study of vitamin D receptor (VDR) gene rs2228570 single nucleotide polymorphism (SNP) genotypes and individual alleles frequency among the Kazakh ethnic group representatives living in the Karaganda region. This SNP was determined by real-time polymerase chain reaction using TaqMan technology. The study relevance is due to the fact that genetic variations in rs2228570 affect the synthesis of the VDR protein and its activity as a transcription factor that regulates the expression of other genes. This mechanism determines the association of individual rs2228570 genotypes or alleles with susceptibility, course, and outcomes of various diseases. The polymorphism frequency may be depending on ethnicity. According to the study results, the most common genotypes of rs2228570 SNP among the Kazakhs were AG (32.8 %) and GG (25.2 %). The rarest are homozygotes TT (1.7 %) and CC (0.8 %). The frequency of all rs2228570 alleles was detected simultaneously in the present study for the first time. G became the predominant allele (51.3 %), less common was A (31.0 %), and the C and T alleles were the rarest (11.8 % and 5.9 %, respectively). The potential value of this SNP further study as a possible factor influencing the body’s susceptibility to various diseases, including COVID-19, is shown.

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Section: Resultsmentioning

confidence: 99%

Frequency of rs2228570 single nucleotide polymorphism of Vitamin-D Receptor (VDR) gene among the Kazakh ethnic group

Protas¹,

Pogossyan²,

Li³

et al. 2023

BMG

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“…In our study, a higher rate of ApaI (50%), BsmI (68.40%), FokI (60%), and TaqI (91.40%) polymorphisms was observed in Iran ( 30 ), Indonesia ( 48 ), Iran ( 29 ), and China ( 50 ). In the study of Protas et al in 2023, it was shown that the VDR polymorphism frequency may depend on ethnicity ( 69 ). The TB report of the World Health Organization (WHO) has shown that the yellow-skinned race is more susceptible to TB than the black and white-skinned race.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Vitamin D Receptor Gees Polymorphisms in People with Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

Samimi,

Hossein Panahi,

Zaboli

et al. 2024

MJIRI

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Background Polymorphisms in the vitamin D receptor (VDR) play an effective role in the susceptibility of pulmonary tuberculosis (TB). Given the importance of this polymorphism and its association with pulmonary TB, this study aimed to investigate the prevalence of VDR polymorphisms in people with pulmonary TB. Methods The search process was performed from 2009 to 2023 according to PRISMA (Preferred reporting items for systematic reviews and meta-analyses). The strengthening of the reporting of observational studies in epidemiology (STROBE) checklist was used to qualify the articles. The data was entered into STATA version 14 software, then the fixed effects model and the random effects model, effect size (ES), and Q test ( P < 0.10) were used for data analysis at a confidence interval level (CI) of 95%. Two-sided statistical tests were considered with α=0.05. Results In this research, 28 articles were analyzed. Polymorphisms showed a significant relationship with susceptibility to pulmonary TB ( P = 0.000), and significant heterogeneity ( P = 0.000) was seen between polymorphisms. FokI (95% CI: 0.39-0.46, P = 0.000, ES = 43%), ApaI (95% CI: 0.31-0.48, P = 0.000, ES = 39%) and BsmI (95% CI: 0.24-0.50, P = 0.000, ES = 37%) showed the most frequent gene polymorphisms after TaqI (95% CI: 0.34-0.77, P = 0.000, ES = 56%). Conclusion ApaI, BsmI, FokI, and TaqI polymorphisms were found in patients suffering from pulmonary TB. Polymorphisms related to the TaqI gene were the most frequent. Controlling and prescribing vitamin D may be needed in these patients.

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Changes in the enamel surface in patients with polymorphism of the <i>VDR</i> gene under the action of remineralizing composition and vitamin D

Tikhonova,

Kozlova,

Gorbatova

et al. 2024

Russian Journal of Dentistry

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AIMS: To study the effect of vitamin D and a remineralizing paste on the enamel surface structure in patients with VDR genetic polymorphism. MATERIALS AND METHODS: 18 people with a polymorphism index of the VDR A/A gene, a laboratory indicator of 25 (OH) vitamin D in the blood of 18.2 ± 1.84 ng/ml, according to orthodontic indications, the retinated third molars of the lower jaw were removed. Next, the samples were lowered into 3 flasks of 6 pieces with 100 ml of artificial saliva. Containers with teeth were divided into groups: the first – with a solution of artificial saliva only; the second – an additional 1000 ML of an aqueous solution of vitamin D; the third – tooth enamel was treated for 2 minutes with an electric toothbrush with a paste containing a remineralizing composition, immersed in artificial saliva with cholecalciferol 1000ME. The flasks were in the thermostat at a temperature of 37.4 C a day. In all samples, electron microscopy of the enamel contact surface at the level of the crown equator was performed with a Tescan Mira LMU microscope with an Oxford X-MAX 5 energy dispersive X-ray detector with analysis of local mineral composition. RESULTS:. In the first group, with electron microscopy of enamel, areas of increased mineralization alternated with areas of reduced density. The coefficient of the molar ratio Ca/P was 1.32 ± 0.13, was regarded as the destruction of hydroxyapatites. In the second group, with vitamin D in artificial saliva, the intercrystalline pore space was filled with calcium and phosphate ions. In the third group, the enamel surface acquired a smooth homogeneous relief. An increase in the weight percentage of trace elements was observed, the Ca/P ratio was 2.2± 0.02, which indicated a phase of remineralization. CONCLUSIONS: Patients with VDR polymorphism have a deficiency of vitamin D in the blood serum. The trace element composition of the enamel surface is characterized by a phase of demineralization. Treatment with remineralizing paste and addition of cholecalciferol solution to artificial saliva, changes the structure of hydroxyappatite, increases the caries-resistant properties of enamel.

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Vitamin D receptor gene polymorphisms characteristic

Cited by 4 publications

References 12 publications

Frequency of rs2228570 single nucleotide polymorphism of Vitamin-D Receptor (VDR) gene among the Kazakh ethnic group

Frequency of rs2228570 single nucleotide polymorphism of Vitamin-D Receptor (VDR) gene among the Kazakh ethnic group

Prevalence of Vitamin D Receptor Gees Polymorphisms in People with Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

Changes in the enamel surface in patients with polymorphism of the <i>VDR</i> gene under the action of remineralizing composition and vitamin D

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