Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis

Selvaraj, P.; Kurian, Sunil M.; Chandra, Girish; Reetha, A M; Charles, N; Narayanan, P. R.

doi:10.1111/j..2004.00183.x

Cited by 55 publications

(57 citation statements)

References 9 publications

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“…In another study, the frequency of Bb genotype was higher in spinal TB than healthy controls [22]. In fact, various diallelic polymorphisms have been identified in the vitamin D receptor gene and these polymorphic variants have been shown to be associated with susceptibility or resistance to tuberculosis [18,21,22]. Our data reconfirmed the association of BsmI polymorphisms (Bb+bb) with tuberculosis.…”

Section: Discussionsupporting

confidence: 79%

“…Generally, the VDR gene with FF genotype demonstrated an increased transcription rate, and this has provided the main explanation for association between FokI genotype and the development of diseases. Previous studies showed 65% frequency of FF genotype among Indian PTB patients and 62% among westAfricans [14,18]. Although in Chinese and Peruvian the frequency was lowered to 24 and 9%, respectively [21,23].…”

Section: Discussionmentioning

confidence: 97%

“…In a study carried out in pulmonary TB patients of south India, the Bb genotype of VDR BsmI was associated with susceptibility to TB, whereas AA genotype of ApaI and BB genotype of BsmI were associated with resistance to pulmonary TB [18,21,22]. In another study, the frequency of Bb genotype was higher in spinal TB than healthy controls [22]. In fact, various diallelic polymorphisms have been identified in the vitamin D receptor gene and these polymorphic variants have been shown to be associated with susceptibility or resistance to tuberculosis [18,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…It has been clearly established that the impact of NRAMPI on tuberculosis susceptibility is best detected when gene-gene or geneenvironment interactions are taken into account in the analysis [16,19,20]. In a study carried out in pulmonary TB patients of south India, the Bb genotype of VDR BsmI was associated with susceptibility to TB, whereas AA genotype of ApaI and BB genotype of BsmI were associated with resistance to pulmonary TB [18,21,22]. In another study, the frequency of Bb genotype was higher in spinal TB than healthy controls [22].…”

Section: Discussionmentioning

confidence: 99%

“…For FokI polymorphisms, the following primers were used to amplify a 265 bp product from the region flanking exon 2 of VDR gene:5' AGC TGG CCC TGG CACTGA CTC TGC TCT-3'; 5'AG GAA ACA CCT TGC TTC TTC TCC CTC-3'. For BsmI polymorphisms, the following primers were used to amplify a 825bp product: 5' CAA CCA AGA CTA CAA GTA [18]. Digested products were run on 8% polyacrylamide gel, and were stained with Silver-Nitrate.…”

Section: Vdr Genotypingmentioning

confidence: 99%

See 4 more Smart Citations

The NRAMPI, VDR and TNF-α gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility

Merza¹,

Farnia²,

Anoosheh³

et al. 2009

Braz J Infect Dis

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Vdr Genotypingmentioning

confidence: 99%

See 3 more Smart Citations

The NRAMPI, VDR and TNF-α gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility

Merza¹,

Farnia²,

Anoosheh³

et al. 2009

Braz J Infect Dis

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Association of VDR‐FokI and VDBP‐Thr420Lys polymorphisms with cervical spondylotic myelopathy: A case‐control study in the population of China

Song

Tian

2018

Clinical Laboratory Analysis

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Background: Cervical spondylotic myelopathy (CSM), a common degenerative disorder, is characterized by chronic progressive compression of the cervical spinal cord.The present case-control study aimed to explore the potential role of VDR-FokI and VDBP-Thr420Lys polymorphisms in the susceptibility to CSM in the Chinese population. Methods: The study enrolled 318 CSM patients and 282 healthy individuals whose clinical data were retrospectively analyzed. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to genotype VDR-FokI and VDBP-Thr420Lys polymorphisms. The severity of CSM was assessed using the Japanese Orthopaedic Association (JOA) score with magnetic resonance imaging (MRI) of cervical vertebra. A nonconditional binary logistic regression model was conducted for assessing the risk factors of CSM. Results: Patients in the CSM group had longer time duration to bend over desk working than the control group. The ff genotype and f allele frequency of VDR-FokI were elevated in CSM patients. Elevated Ff + ff genotype and f allele frequency of VDR-FokI might increase the risk of CSM. The VDR-FokI polymorphism was associated with nucleus pulposus capillary invasion, necrosis, hyaline degeneration and fibrosis, genesis and hyperplasia of cartilage-like cells, and fibrocyst in the fibrous ring. The VDR-FokI and VDBP-Thr420Lys genotypes conformed to Hardy-Weinberg equilibrium which showed that VDR-FokI and VDBP-Thr420Lys had group representation characteristics. Conclusion: Binary logistic regression analysis confirmed that VDR-FokI polymorphism and the time to bend over desk working were risk factors of CSM. Our results indicate that VDR-FokI polymorphism may be closely associated with the risk of CSM. K E Y W O R D S cervical spondylotic myelopathy, FokI, polymorphism, Thr420Lys, VDBP, VDR

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Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom

et al. 2010

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Genetic associations of TNFR2, VDR (Bsm I and Fok I), A2M, GSTT(1), GSTM(1) and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R-R (OR = 3.16, CI 1.20-9.26, P < 0.05), A2M 1-1 (OR = 2.09, CI 1.21-3.64, P < 0.05) and GST T(1)null (OR = 1.97, CI 1.07-3.68, P < 0.05) among Caucasian patients. In South Asians, VDR Bsm I B-B genotype (OR = 2.08, CI 1.23-3.52, P < 0.05), A2M 2-2 genotype (OR = 3.99, CI 1.19-17.18, P < 0.05), and GST T(1)null genotype (OR = 2.81, CI 1.40-5.77, P < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA.

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Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis

Cited by 55 publications

References 9 publications

The NRAMPI, VDR and TNF-α gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility

The NRAMPI, VDR and TNF-α gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility

Association of VDR‐FokI and VDBP‐Thr420Lys polymorphisms with cervical spondylotic myelopathy: A case‐control study in the population of China

Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom

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