Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort

Li, Zhenze; Yuan, Weitang; Ning, Shijie; Zhang, S.J.

doi:10.4238/2014.july.24.18

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…Hence there is a great need to explore genes related to GBC susceptibility. Table 8[30,214-273] shows an overview of candidate gene studies reported in GBC.…”

Section: Methylation and Gallbladder Cancermentioning

confidence: 99%

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Sharma

Gupta

et al. 2017

WJG

323

256

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Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defined pathogenesis. An understanding to the relationship between epidemiology, molecular genetics and pathogenesis of gallbladder cancer can add new insights to its undetermined pathophysiology. Present review article provides a recent update regarding epidemiology, pathogenesis, and molecular genetics of gallbladder cancer. We systematically reviewed published literature on gallbladder cancer from online search engine PubMed (http://www.ncbi.nlm.nih.gov/pubmed). Various keywords used for retrieval of articles were Gallbladder, cancer Epidemiology, molecular genetics and bullion operators like AND, OR, NOT. Cross references were manually searched from various online search engines (http://www.ncbi.nlm.nih.gov/pubmed,https://scholar.google.co.in/, http://www.medline.com/home.jsp). Most of the articles published from 1982 to 2015 in peer reviewed journals have been included in this review.

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“…Hence there is a great need to explore genes related to GBC susceptibility. Table 8[30,214-273] shows an overview of candidate gene studies reported in GBC.…”

Section: Methylation and Gallbladder Cancermentioning

confidence: 99%

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Sharma

Gupta

et al. 2017

WJG

323

256

View full text Add to dashboard Cite

show abstract

“…We choose 14 papers out of 96 which showed a statistically significant odds ratio for carriage of allele F in sexdependent cancers in male and female groups together [20][21][22][23][24][25][26][27][28][29][30][31][32][33] (p < 0.05). The results were inconsistent: allele F was reported to be associated with cancer risk in eight papers (BC, CRC, CM, LC, GBC) and allele f in six papers (BC, RCC, MM, HCC, BCC, PCa, CM) ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

Association of the vitamin D receptorFokIgene polymorphism with sex- and non-sex-associated cancers: A meta-analysis

et al. 2017

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Currently higher morbidity and mortality rates are observed in cancer diseases, especially sex-dependent cancers. A positive role of endogenous vitamin D concentration in cancer diseases has been reported in many publications. Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism. The aim of this study was to investigate whether the vitamin D receptor FokI polymorphism is associated with cancerogenesis in sex-dependent cancers. The MEDLINE and ResearchGate databases were used to search for articles up to January 2017, and 96 articles concerning the FokI polymorphism were chosen. Odds ratios with 95% confidence intervals were used to assess the strength of associations between polymorphisms of vitamin D receptor and cancer risk in the described populations. The fixed-effects model and the DerSimonian-Laird random-effects model (with weights based on the inverse variance) were used to calculate summary odds ratios, and both within- and between-study variation were considered. Generally, the F variant reduces the risk of cancer by 4% (odds ratio = 0.96, p value = 0.0057). This effect is particularly evident in female sex-associated cancers (odds ratio = 0.96, 95% confidence interval: 0.93-0.99, p value = 0.0259), but it is not observed in non-sex-associated cancers. Polymorphism FokI is associated with breast and ovarian cancers.

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Vitamin D Receptor Polymorphisms and Cancer

Gandini

Gnagnarella

Serrano

et al. 2014

Sunlight, Vitamin D and Skin Cancer

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Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort

Cited by 7 publications

References 36 publications

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Association of the vitamin D receptorFokIgene polymorphism with sex- and non-sex-associated cancers: A meta-analysis

Vitamin D Receptor Polymorphisms and Cancer

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