Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer

Abstract

BACKGROUND: Recently, the vitamin D receptor (VDR) polymorphism FokI was shown to be associated with susceptibility to ovarian cancer. We aimed to examine whether VDR FokI polymorphisms influence the survivals of patients with epithelial ovarian cancer (EOC). METHODS: VDR polymorphisms from FokI in 101 patients with EOC were genotyped by sequencing. Overall survival was compared between FokI single nucleotide polymorphism using Kaplan -Meier survival curves with log-rank tests and the Cox proportional hazard model adjusted for ages, stages, histology, and existence of residual tumour. RESULTS: The FokI C/C genotypes were associated with better prognosis compared with the C/T and T/T genotypes (log-rank test: P ¼ 0.008; adjusted hazard ratio, 0.18; 95%CI 0.05 -0.61; P ¼ 0.006). CONCLUSIONS: These results suggest that the VDR polymorphisms from the FokI genotype may be associated with improved prognosis of patients with EOC.

Vitamin D Receptor Gene BsmI and FokI Polymorphisms in Relation to Ovarian Cancer Risk in the Polish Population

“…A recently conducted pooled analysis of five studies, including 1820 white non-Hispanic cases and 3479 controls, confirmed that the FokI T (f) allele is associated with ovarian cancer (Lurie et al, 2011). In addition, Tamez et al (2009) demonstrated that, in a Japanese population, the FokI CC (FF) genotype was associated with better survival compared to the CT (Ff) or TT (ff) genotypes (Tamez et al, 2009). …”

“…In recent years, the relevance of VDR polymorphisms as risk factors for the development of various types of cancer, including ovarian cancer, has been evaluated in numerous population studies (Lurie et al, 2007(Lurie et al, , 2011Clendenen et al, 2008;Kö stner et al, 2009;Tamez et al, 2009;Tworoger et al, 2009). However, these studies have demonstrated variable and inconsistent results (Lurie et al, 2007(Lurie et al, , 2011Clendenen et al, 2008;Tamez et al, 2009;Tworoger et al, 2009). Therefore, we aimed to study whether the FokI and BsmI SNPs situated in the VDR gene can be a genetic risk factor of ovarian cancer in the Polish population.…”

“…The most frequently studied VDR single-nucleotide polymorphisms (SNPs) include rs10735810/rs2228570 (FokI) and three other SNPs, namely rs1544410 (BsmI), rs731236 (TaqI), and rs7975232 (ApaI), situated in the same linkage disequilibrium (LD) block (Uitterlinden et al, 2004). In recent years, the relevance of VDR polymorphisms as risk factors for the development of various types of cancer, including ovarian cancer, has been evaluated in numerous population studies (Lurie et al, 2007(Lurie et al, , 2011Clendenen et al, 2008;Kö stner et al, 2009;Tamez et al, 2009;Tworoger et al, 2009). However, these studies have demonstrated variable and inconsistent results (Lurie et al, 2007(Lurie et al, , 2011Clendenen et al, 2008;Tamez et al, 2009;Tworoger et al, 2009).…”

Prognostic Role of Vitamin D Status and Efficacy of Vitamin D Supplementation in Cancer Patients: A Systematic Review

“…In one study involving ovarian cancer patients, the Fok1 C/C genotype was associated with a better prognosis than with the C/T and T/T genotypes (HR, 0.18; 95% CI, 0.05-0.61) [30]. The number of stars attributed to each domain is a measure of study validity.…”

Plasma vitamin D levels and vitamin D receptor polymorphisms are associated with survival of non-small cell lung cancer

“…Recently, several studies reported that genetic variations of VDR were associated with progression and prognosis of common cancers [14][15][16][17][18][19][20] , including lung cancer [14,15] . Zhou et al reported that patients with variant genotypes of rs11568820 (GA/AA) had a longer survival time than those with GG genotype in early-stage lung squamous cell carcinoma.…”