Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

Abstract

Background: Osteoporosis is a disease of the bones in which the density of the bones decreases. The prevalence of this disease greatly varies in different populations of the world. Numerous studies have been investigated VDR gene polymorphisms as osteoporosis risk in different ethnic groups. In present meta-analysis, the aim is to find out the role of VDR gene polymorphisms (FokI, BsmI, ApaI, and TaqI) in osteoporosis risk. Methods: Suitable case-control studies for present meta-analysis were retrieved from four electronic databases. Open Meta-Analyst program was used for statistical analyses. Results: Studies investigated BsmI (65 studies; 6880 cases/8049 controls), ApaI (31 studies; 3763 cases/3934 controls), FokI (18 studies; 1895 cases/1722 controls), and TaqI (26 studies; 2458 cases/2895 controls) polymorphisms that were included in the present meta-analysis. A significant association was found between the dominant model of FokI (OR ff + Ffvs.FF = 1.19, 95% CI = 1.04-1.36, p = 0.01, I 2 = 39.36%) in the overall analysis and recessive model of the Caucasian population of TaqI polymorphism (OR TT + Ttvs.tt = 1.35, 95% CI = 1.11-1.63, p = 0.002, I 2 = 50.07%) with osteoporosis. On the other hand, no such effect is found in any other genetic models and in any other gene polymorphisms of the overall analyses or subgroup analyses. Conclusion: In conclusion, the authors found that the dominant model of FokI in the overall analysis and recessive model of TaqI in the Caucasian population are significantly associated with the development of osteoporosis.

Skeletal Abnormalities and VDR1 Gene Polymorphisms in Mucopolysaccharidosis Patients

“…ApaI polymorphism was associated with protection against osteoporosis; 23,25 however, there are other studies that find some detrimental effects or no effect at all on osteoporosis. [26][27][28] BsmI polymorphism was associated with an increased risk of osteoporosis, 23 but other authors have not found any association. 28,29 FokI and TaqI were significantly associated with the development of osteoporosis.…”

“…[26][27][28] BsmI polymorphism was associated with an increased risk of osteoporosis, 23 but other authors have not found any association. 28,29 FokI and TaqI were significantly associated with the development of osteoporosis. 23,25,28 Fok1 is located in exon 2 of the gene and leads to the formation of a new start codon, resulting in a shorter VDR product that interacts more efficiently with the transcription factor TFIIB.…”

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

“…The original data of all published eligible studies were almost covered by this meta-analysis. However, according to a recently published meta-analysis of Yadav et al [61], in the absence of a subgroup analysis based on the sex and age of patients or the type of osteoporosis, BsmI polymorphism seemed not to be associated with the pathogenesis of osteoporosis. It indicated that possible relationship between VDR gene polymorphisms and osteoporosis may be related to gender, race, and age difference of subjects.…”

Title: Vitamin D Receptor Bsm I Polymorphism and Osteoporosis Risk in postmenopausal women: A Meta-Analysis from 42 Studies

“…Through sensitivity analysis and publication bias detection, the results of this meta-analysis were true and credible.The original data of all published eligible studies were almost covered by this meta-analysis. However, according to a recently published meta-analysis of Yadav(2020) 59 , in the absence of a subgroup analysis based on the sex and age of patients or the type of osteoporosis, BsmI polymorphism seemed not be associated with the pathogenesis of osteoporosis. It indicated possible the relationship between VDR gene polymorphisms and osteoporosis may be related to gender, race and age difference of subjects.…”