Vitamin D serum levels in children with allergic and vasomotor rhinitis

Lee, Seung Jin; Kang, Boyoung; 최봉석,

doi:10.3345/kjp.2015.58.9.325

Cited by 20 publications

(20 citation statements)

References 21 publications

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“…IgE, which mediates allergic immune responses, has been shown to have an inverse relationship with serum vitamin D levels. Patients with low levels of vitamin D have high levels of IgE [14]. IgE is the basis of all allergic responses.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Serum Immunoglobulin E Levels in Allergic Rhinitis: A Case-control Study from Pakistan

Ansari

Memon²,

Brohi

et al. 2019

Cureus

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Introduction Allergic rhinitis (AR) is the most common non-infectious rhinitis and is associated with sneezing, cough, and flu-like symptoms. The exact pathophysiology of AR remains uncertain. The deficiency of vitamin D 3 has been documented as a probable cause of allergic conditions due to its role in immunomodulation. The aim of this study was to evaluate the role of vitamin D 3 deficiency in allergic rhinitis. Methods This case-control study was conducted with 50 patients of AR and 50 healthy individuals. Serum immunoglobulin (Ig) E and vitamin D 3 levels were measured in all study participants. Data were analyzed using SPSS v. 21.0 (IBM Corp., Armonk, NY). Results Mean serum IgE levels in the AR group were 553.5 ± 53.9 IU/L as compared to 219.4 ± 32.1 IU/L in the control group (p <0.0001). AR patients had mean serum vitamin D levels of 14.8 ± 7.4 ng/mL as compared to 19.1 ± 6.6 ng/mL in the control group (p=0.002). Only 10% of participants in the AR group had adequate serum vitamin D levels as compared to 26% in the controls (p=0.08). Conclusion Vitamin D deficiency was present in both study groups. The AR group had significantly lower mean levels of serum vitamin D than the control group. However, upon stratification, the differences were insignificant.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and Serum Immunoglobulin E Levels in Allergic Rhinitis: A Case-control Study from Pakistan

Ansari

Memon²,

Brohi

et al. 2019

Cureus

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“…Calcitriol enhances the antimicrobial effects of monocytes and macrophages, which exert a pivotal role in infections such as tuberculosis [ 23 ]. Low serum 25(OH)D levels are associated with increased incidence of upper respiratory tract infections, chronic obstructive pulmonary disease (COPD), allergic asthma and allergic rhinitis [ 24 , 25 ]. Recurrent infections and immune system dysregulation may promote the development of tonsillar hypertrophy and chronic rhinitis, both of which increase the risk of OSAS [ 26 ].…”

Section: Osas and Vitamin D Insufficiencymentioning

confidence: 99%

The role of vitamin D in obstructive sleep apnoea syndrome

Archontogeorgis

Nena

Παπάνας

et al. 2018

Breathe

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Obstructive sleep apnoea syndrome (OSAS) is a common disorder of multifactorial pathogenesis and is associated with obesity, diabetes and cardiovascular disease. Vitamin D is a fat-soluble vitamin with an important function in calcium absorption and homeostasis, which is also implicated in several nonskeletal conditions. The prevalence of vitamin D deficiency is increasing worldwide and is associated with similar metabolic disturbances to OSAS. Moreover, recent data suggest that in OSAS patients serum levels of vitamin D are lower compared with non-apnoeic subjects. However, the mechanisms linking vitamin D deficiency and OSAS are not completely understood and several hypotheses have been advanced. To date, a limited number of studies have assessed the association between lower serum concentrations of vitamin D and OSAS, and have reported inconsistent results. Similarly, contradictory results have been produced by studies which evaluated the effect of continuous positive airway pressure treatment on serum vitamin D levels. The aim of this review is to summarise current knowledge on the association between OSAS and vitamin D levels.Key pointsVitamin D insufficiency prevalence is increasing worldwide and presents with similar comorbidities and risk factors to OSAS.The nonskeletal actions of vitamin D may contribute to the development of OSAS through immune system modulation, myopathy and inflammation.Studies evaluating serum vitamin D concentrations in OSAS patients and the effect of CPAP treatment report contradictory results, often influenced by confounding factors, such as obesity.There appears to be potential for use of vitamin D supplementation in OSAS patients as a means of reducing the incidence of cardiovascular disease, a comorbidity common in both conditions.Educational aimsTo assess the potential association between OSAS and serum levels of vitamin D.To discuss the pathogenetic mechanisms linking OSAS and vitamin D insufficiency.To illustrate the effect of CPAP treatment on vitamin D concentration in OSAS patients.

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“…The evidence that the peak of viral infection is in the winter time when synthesis of vitamin D across the skin is naturally impaired supported that association. In addition, other studies have proved that vitamin D deficiency in pregnant women may result in increased risk of respiratory tract infections in their infants [44][45][46][47][48][49]. The majority of immune cells express VDRs, mainly after they themselves have been stimulated [40,41,48].…”

Section: Vitamin D and Asthmamentioning

confidence: 99%

Immunomodulatory Effect of Vitamin D in Children with Allergic Diseases

Stelmach¹,

Jerzyńska²,

Podlecka³

2017

A Critical Evaluation of Vitamin D - Basic Overview

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The discovery that many cells express vitamin D receptors and the recognition of widespread vitamin D insufficiency has stimulated interest in the potential role of vitamin D in nonskeleton conditions. There is an increasing evidence to support the role of vitamin D pathway in the regulation of the function of both innate and adoptive immune systems. Vitamin D regulates immune function by inhibiting the differentiation and maturation of human dendritic cells, enhancing interleukin (IL)-10 and tumor growth factor-β (TGF-β) secretion and inhibiting T-cell functions. Vitamin D has the ability to suppress inflammatory cytokines, such as tumor necrosis factor (TNF), interleukin-1 (IL-1), interferon gamma (IFN-γ), and interleukin-2 (IL-2), while it increases the generation of anti-inflammatory cytokines IL-4 and IL-10. In B cells, vitamin D3 has also been shown to suppress immunoglobulin E (IgE) antibody class switch partly through the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).

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Vitamin D serum levels in children with allergic and vasomotor rhinitis

Cited by 20 publications

References 21 publications

Vitamin D and Serum Immunoglobulin E Levels in Allergic Rhinitis: A Case-control Study from Pakistan

Vitamin D and Serum Immunoglobulin E Levels in Allergic Rhinitis: A Case-control Study from Pakistan

The role of vitamin D in obstructive sleep apnoea syndrome

Immunomodulatory Effect of Vitamin D in Children with Allergic Diseases

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