Vitamin D Status among Young Children Aged 1–3 Years: A Cross-Sectional Study in Wuxi, China

Zhao, Xin; Xiao, Jia; Liao, Xiang‐Peng; Lv, Cai; Xu, Fei; Chen, Daozhen; Xiang, Jun; Fang, Rui

doi:10.1371/journal.pone.0141595

Cited by 27 publications

(44 citation statements)

References 33 publications

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“…The cohort presented in the current study is much larger than these previous studies and included infants with different feeding patterns, and the blood sampling was across the calendar year. A large population‐based study performed in Wuxi, China (32°N; Zhao et al, ) reported serum 25OHD concentrations in 3,845 1‐year‐old children with median (IQR) of 74.7 (56.4, 94.3) nmol/L. Our study found the M ± SD 25OHD was 82.9 ± 24.9 nmol/L and median (IQR) 25OHD was 80.8 (67.5, 95.7) nmol/L in 6‐month‐old infants.…”

Section: Discussionsupporting

confidence: 47%

Serum 25 hydroxyvitamin D status in 6‐month‐old infants in Guangzhou, China: A paired longitudinal follow up study

Wang

Zhang

et al. 2020

Maternal & Child Nutrition

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To assess the vitamin D status in healthy 6‐month‐old infants, as well as vitamin D supplementation and feeding patterns in Guangzhou, China, serum 25‐hydroxyvitamin D (25OHD) concentrations of 202 infants were measured at birth (cord blood) and at 6 months of age in Guangzhou, China. Questionnaires acquiring demographic characteristics, maternal and infantile vitamin D supplementation during pregnancy and first 6 months after birth, and feeding patterns during the first 6 months were completed by participating mothers. Physical examinations and blood sampling were carried out among infants at 6 months of age. The majority of infants (93.6%) were supplemented with vitamin D during the first 6 months of life on a voluntary basis. The M ± SD of cord serum 25OHD concentration was 46.2 ± 16.4 nmol/L, whereas the M ± SD of 25OHD concentration at 6 months was 82.9 ± 24.9 nmol/L. Serum 25OHD concentrations <30 nmol/L were seen in 34 (16.8%) infants at birth but only one (0.5%) at 6 months. Only 11 (5.4%) infants had concentrations >75 nmol/L at birth, whereas the majority of infants (n = 131, 64.9%) had concentrations >75 nmol/L at 6 months. The main predictors of 25OHD levels at 6 months included season, vitamin D supplementation, parental education level, and feeding patterns. To conclude, serum 25OHD concentrations were low at birth in a southern Chinese population, and infantile supplementation is an effective way to improve 25OHD status. Exclusively breastfed infants might need greater vitamin D supplementation, and individualized vitamin D supplementation plans might be needed.

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Section: Discussionsupporting

confidence: 47%

Serum 25 hydroxyvitamin D status in 6‐month‐old infants in Guangzhou, China: A paired longitudinal follow up study

Wang

Zhang

et al. 2020

Maternal & Child Nutrition

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“…It can supply our body's required vitamin D by exposing daily to sunlight with uncovered skin of face, arms, back and legs for at least 5 to 30 minutes between 10 am and 3 pm. Currently, food sources and vitamin D supplements are very important for us due to lifestyle changes, air pollution and decreases in duration of sunlight exposure (2,(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Vitamin D Deficiency Among Children of 1 - 6 Years Old, Tehran, Iran

Babaniamansour

Hematyar

Babaniamansour

et al. 2019

J Kermanshah Univ Med Sci

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Background: Vitamin D has an essential role in bone growth and metabolism. Currently, its role has been investigated in different diseases. It is high prevalence of vitamin D deficiency in the world, particularly in developing countries. Objectives: The aim of this study is to investigate the prevalence of vitamin D deficiency in children of 1 -6 years old and its relation with their age, sex and body mass index. Methods: This study was conducted in pediatric clinic of Javaheri Hospital in Tehran, from 2016 to 2017. The study population was children of 1 -6 years old presenting to the pediatric clinic for routine examination or treatment. The collected data included age, gender, height, weight, and serum 25-hydroxy vitamin D level. Results: Of the total population of 288 children, 47.2% were female and 52.8% were male. The prevalence of vitamin D deficiency was 51%, while 4.51% had severe deficiency (level of vitamin D < 10 ng/mL). The relation between the level of vitamin D and variables of gender, height, weight, and body mass index was not statistically significant. Nonetheless, the level of vitamin D had a statistically significant relation with age such that, serum level of 25(OH) vitamin D reduced by 3.47 ng/mL for every one year of age (P < 0.001). Conclusions:The prevalence of vitamin D deficiency is increasing with increasing age. Therefore, adoption of preventive and therapeutic measures is necessary to reduce its prevalence and side effects.One billion people worldwide suffer from vitamin D deficiency, with a high prevalence in the Middle East countries such as Iran, especially in children under 12, with a prevalence range of 25 to 85% (1,2,8,12,13,(17)(18)(19)(20).Since Iran has adopted the policy to prevent vitamin D

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“…Vitamin D deficiency (VDD) has become a public health issue both in developed and developing countries [4-6]. It is estimated that more than 1 billion people have suffered from VDD [7]. VDD causes a variety of disorders that include but are not limited to calcium and phosphorus metabolism disorder, infection, autoimmune disease, tumours and allergic disease [8-10].…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

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Vitamin D Status among Young Children Aged 1–3 Years: A Cross-Sectional Study in Wuxi, China

Cited by 27 publications

References 33 publications

Serum 25 hydroxyvitamin D status in 6‐month‐old infants in Guangzhou, China: A paired longitudinal follow up study

Serum 25 hydroxyvitamin D status in 6‐month‐old infants in Guangzhou, China: A paired longitudinal follow up study

The Prevalence of Vitamin D Deficiency Among Children of 1 - 6 Years Old, Tehran, Iran

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

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