Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression – The Northern Finland Birth Cohort 1966 study

Ikonen, H.; Palaniswamy, Saranya; Nordström, Tanja; Järvelin, Marjo‐Riitta; Herzig, Karl Heinz; Jääskeläinen, Erika; Seppälä, Jussi; Sebért, Sylvain

doi:10.1016/j.psychres.2019.02.060

Cited by 15 publications

(15 citation statements)

References 39 publications

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“…Contrary to our results, a study has concluded that serum vitamin D levels were lower in patients with schizophrenia compared to patients with MDD and to healthy controls [57]. In another study, no differences were found in vitamin D level between schizophrenia and non-psychotic depression [47]. This finding warrants further investigation and needs to be replicated on a wider scale to be confirmed.…”

Section: Vitamin D Status In the Depression Group Vs Schizophrenia Gcontrasting

confidence: 99%

“…Other studies had equivocal results [44,46]. For example, one study found no difference in serum vitamin D level between depression and healthy controls [47], which could be attributed to different study design; while we used standardized tool for psychiatric diagnoses, they used register-based diagnoses.…”

Section: Vitamin D Status In the Patient Groups And Healthy Controlsmentioning

confidence: 88%

“…For example, in a recent study, although serum vitamin D tended to be lower in the group with schizophrenia than in the control group, this difference did not reach statistical significance. However, this study used a nonclinical sample drawn from the general population, which is more likely to have less severity of psychotic symptoms [47].…”

Section: Vitamin D Status In the Patient Groups And Healthy Controlsmentioning

confidence: 99%

“…In addition, there was non-significant diagnostic performance for vitamin D level in differentiating MDD group from schizophrenia group. Some studies agreed that vitamin D concentration did not differ between schizophrenia or depression [47,64].…”

Section: Diagnostic Performance Of Vitamin D In Mdd and Schizophreniamentioning

confidence: 99%

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Vitamin D serum level in major depressive disorder and schizophrenia

Okasha

Sabry

Hashim

et al. 2020

Middle East Curr Psychiatry

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Background: Vitamin D is involved in many brain processes including neurological immune process, regulation of neurological factors, and neuroplasticity. Some studies have linked low serum vitamin D to major depressive disorder (MDD) and schizophrenia, while others have not shown any relationship. The study aimed to assess vitamin D level in patients with depression and those with schizophrenia. Sixty participants were recruited from outpatient clinics of the

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Section: Vitamin D Status In the Depression Group Vs Schizophrenia Gcontrasting

confidence: 99%

Section: Vitamin D Status In the Patient Groups And Healthy Controlsmentioning

confidence: 88%

Section: Vitamin D Status In the Patient Groups And Healthy Controlsmentioning

confidence: 99%

Section: Diagnostic Performance Of Vitamin D In Mdd and Schizophreniamentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D serum level in major depressive disorder and schizophrenia

Okasha

Sabry

Hashim

et al. 2020

Middle East Curr Psychiatry

View full text Add to dashboard Cite

show abstract

“…Three observational studies have been published since the most recent meta-analysis. [96][97][98] In these studies, the relationship between depression and VIT-D deficiency was less clear. One study failed to find a significant difference in participants with non-psychotic depression and controls.…”

Section: Proof Of Principle Laboratory Findingsmentioning

confidence: 99%

Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective

Werneke

Gaughran

Taylor

2021

Therapeutic Advances in Psychopharmacology

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Individuals with serious mental disorders (SMD) may have a higher risk of vitamin D (VIT-D) deficiency. They also experience higher mortality because of coronavirus disease 2019 (COVID-19) infection. Therefore, we have conducted a comprehensive review to examine the significance of VIT-D for public health and public mental health during the ongoing COVID-19 pandemic. This review had three specific aims, from a global perspective to (a) create a profile of VIT-D and review the epidemiology of VIT-D deficiency, (b) explore VIT-D deficiency as risk factor for SMD and COVID-19 infections and (c) examine the effectiveness of VIT-D supplementation for both conditions. We found that, in terms of SMD, the evidence from laboratory and observational studies points towards some association between VIT-D deficiency and depression or schizophrenia. Mendelian randomisation studies, however, suggest no, or reverse, causality. The evidence from intervention studies is conflicting. Concerning COVID-19 infection, on proof of principle, VIT-D could provide a plausible defence against the infection itself and against an adverse clinical course. But data from observational studies and the first preliminary intervention studies remain conflicting, with stronger evidence that VIT-D may mitigate the clinical course of COVID-19 infection rather than the risk of infection in the first place. From a public health and public mental health point of view, based on the currently limited knowledge, for individuals with SMD, the benefits of VIT-D optimisation through supplementation seem to outweigh the risks. VIT-D supplementation, however, should not substitute for vaccination or medical care for COVID-19 infection.

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Nutritional interventions for early psychosis: a systematic review and network meta-analysis

Gao,

Zhu,

Zeng

et al. 2024

Cochrane Database of Systematic Reviews

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Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression – The Northern Finland Birth Cohort 1966 study

Abstract: Title Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression-The Northern Finland Birth Cohort 1966 study Article type Full Length Article

Cited by 15 publications

References 39 publications

Vitamin D serum level in major depressive disorder and schizophrenia

Vitamin D serum level in major depressive disorder and schizophrenia

Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective

Nutritional interventions for early psychosis: a systematic review and network meta-analysis

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