Vitamin D Supplementation for Extraskeletal Indications in Older Persons

Bode, Lauren E.; Brown, Mallory McClester; Hawes, Emily M.

doi:10.1016/j.jamda.2019.09.021

Cited by 14 publications

(15 citation statements)

References 59 publications

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“…A combination of resistance exercises and nutritional supplements is reported to have more apparent protective and healing effects (28). Vitamin D supplementation specifically for sarcopenia was found to have insufficient evidence, though there is evidence that persons with low vitamin D levels may improve their strength with vitamin D supplementation (33). Since oxidative stress is also in the aetiology of sarcopenia, use of antioxidants (vitamin E, Selenium, vitamin C, etc.)…”

Section: Treatment Optionsmentioning

confidence: 99%

Sarcopenia: Again and Updated

Kutsal¹

2020

tjgeri

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Sarcopenia is defined as, skeletal muscle dysfunction associated with age, chronic diseases, cancer, nutrition problems and physical inactivity. The pathophysiology of sarcopenia seems to involve degeneration of neurogenic, musculogenic, synaptogenic and vasculogenic systems, mitochondrial dysfunction, metabolic factors and inflammatory mechanisms. Early detection of sarcopenia in older adults and patients is important to prevent morbidity, functional decline and death and the diagnosis requires assessment of muscle mass, muscle strength and physical performance. The strongest evidences in the treatment of sarcopenia are probably associated with the positive effects of resistance exercises on muscle strength, muscle mass and physical performance. Also protein intake needs to be increased. Positive results have been reported on supplementation with leucine, βhydroxy β-methylbutyrate, Omega 3 and Vitamin D. Antioxidant intake naturally from food is recommended. There are promising studies related to angiotensin receptor blockers, oral anti-diabetic drugs. Interventions to prevent sarcopenia, treatment of the primarily responsible disease, suppression of inflammation, and treatment of metabolic syndromes constitute the basic components of a successful treatment.

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Section: Treatment Optionsmentioning

confidence: 99%

Sarcopenia: Again and Updated

Kutsal¹

2020

tjgeri

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“…Hasan ALwan Baiee/ University of Babylon-Hammurabi College of Medicine. email: hassanbaey@yahoo .com Evidence suggests that vitamin D supplementation may decrease mortality rates 4 . The prevalence of vitamin D inadequacy varied not only between different countries, but there were intra country variations.…”

Section: Corresponding Authormentioning

confidence: 99%

Prevalence and Correlates of Vitamin D Inadequacy in a Sample of Iraqi People

2020

IJFMT

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Background: Vitamin D had been identified as a common metabolic/endocrine abnormality. Middle East countries had a very high rate of vitamin D inadequacy, vitamin D deficiency was associated with noncommunicable and infectious diseases.Objective : To identify the prevalence of Vitamin D level and its correlates among Iraqi people in Al-Hilla city-Babylon province Methods :. A cross-sectional study was conducted on a convenient sample of individuals from all age groups and both genders who attended eight primary health care centers and individuals in Al-Hilla city\Babylon province\Iraq, the study period was started from May through October , 2019. A pretested questionnaire was used for data collection , the questionnaire included information regarding socio demographic characteristics of participants and their history of chronic diseases. The following measurements were done: level of serum vitamin D , blood pressure, blood sugar , body weight and weight and the serum of vitamin D .Results: The sample included 188 participants their mean age was 64.8 ± 17.25 years.The female to male ratio 1.7:1, More than half of participants (56%) resident in urban areas . Vitamin D mean level was (20.7 ng/mL ± 14.9 SD). The vast majority (80%) of the sample have vitamin D inadequacy in which (66% have deficiency and 14% have insufficiency), while 37 (20%) of the sample have vitamin D adequacy.A significant inverse relationship between vitamin D serum level and hypertension, type two diabetes mellitus, increase body weight. Conclusion:there was a high prevalence of vitamin D inadequacy among Iraqi people mainly in females, a significant association between low vitamin D level and hypertension, type two diabetes mellitus, and obesity.

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“…Several reasons are currently recognised for the higher tendency to develop VITD deficiency in the elderly. First of all, they have less daily sun exposure and a reduced cutaneous synthesis, thus leading to decreased dermal productions of cholecalciferol [ 21 ]. Secondly, renal function, declining with age, leads to a decrease in the activity of the renal enzyme 1alpha-hydroxylase that converts 25(OH)D into calcitriol.…”

Section: Introductionmentioning

confidence: 99%

“…Calcitriol levels have been shown to be inversely linked to the serum creatinine levels and to the glomerular filtration rate [ 22 ]. Other factors involved are the reduced VDR expression in skeletal muscles and the decline in the intestine’s sensitivity to calcitriol, and the consequent reduction in calcium absorption [ 21 ]. Low levels of VITD have been implicated in various frequent diseases in the geriatric population, including fractures, functional limitations, cancer, cardiovascular diseases and depression.…”

Section: Introductionmentioning

confidence: 99%

“…Low levels of VITD have been implicated in various frequent diseases in the geriatric population, including fractures, functional limitations, cancer, cardiovascular diseases and depression. Additionally, mortality has been associated with low VITD [ 21 ]. Serum levels of VITD are independently related to the loss of muscle mass and to muscle strength decline [ 23 ], suggesting that older people with VITD deficiency are overly exposed to develop sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D in the Covid-19 era: a review with recommendations from a G.I.O.S.E.G. expert panel

et al. 2021

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Vitamin D (VITD) is a key hormone for bone health and has relevant extra-skeletal effects that might play a role in the prevention and treatment of COronaVIrus Disease 19 . Literature regarding this scenario is voluminous but controversial. Glucocorticoid Induced Osteoporosis Skeletal Endocrinology Group (G.I.O.S.E.G) has been present in the scientific debate about the use of VITD and has regularly interfaced national regulatory agencies to ensure appropriateness of its employment. Given the current pandemic and the questions on COVID-19 and VITD, G.I.O.S.E.G. appointed an expert panel to advise how to consider this issue best. The results of these deliberations are reported in the current recommendation paper.

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Vitamin D Supplementation for Extraskeletal Indications in Older Persons

Cited by 14 publications

References 59 publications

Sarcopenia: Again and Updated

Sarcopenia: Again and Updated

Prevalence and Correlates of Vitamin D Inadequacy in a Sample of Iraqi People

Vitamin D in the Covid-19 era: a review with recommendations from a G.I.O.S.E.G. expert panel

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