Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial

Rahnemaei, Fatemeh Alsadat; Gholamrezaei, Ali; Afrakhteh, Maryam; Zayeri, Farid; Vafa, Mohammad Reza; Rashidi, Arian; Ozgoli, Giti

doi:10.5468/ogs.20316

Cited by 22 publications

(44 citation statements)

References 33 publications

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“…Vitamin D is essential for metabolic homeostasis and physiological function [5]. It has also been proposed to lessen or prevent female reproductive disorders [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial

Sarebani¹,

Chegini²,

Chen³

et al. 2023

Obstet Gynecol Sci

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Vaginal atrophy, the second most common complication of menopause, can lead to sexual dysfunction. This study evaluated the effect of a vitamin D vaginal suppository on sexual function in postmenopausal women. MethodsThis three-arm randomized controlled trial was conducted between August 2019 and August 2020. The sample comprised 105 postmenopausal women who were referred to comprehensive health service centers to receive postmenopausal care. The inclusion criteria were as follows: (i) menopausal for at least 1 year, (ii) married, (iii) sexually active, and (iv) sexual desire. Participants were randomly assigned to three groups for 8 weeks of treatment: intervention (vaginal suppository containing 1,000 units of vitamin D3), placebo (vaginal suppository placebo), or control (no treatment).The main outcome measure was sexual function, which was assessed using the female sexual function index (FSFI) 4 times during the study (i.e., 1 month before the intervention, immediately after the intervention, 1 month after the intervention, and 2 months after the intervention). ResultsImmediately and 1 month after the trial, the intervention group had the highest FSFI score, followed by the placebo group, both of which were significantly higher than those of the control group (P<0.05). At the 2-month follow-up, the intervention and placebo groups had similar FSFI scores (P=0.08), both of which were significantly higher than those in the control group (P=0.001 and P=0.03, respectively). ConclusionVitamin D vaginal suppositories were more effective at improving sexual function among postmenopausal women in the short term and appeared to prevent agingrelated sexual function decline in the long term.

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“…Vitamin D is essential for metabolic homeostasis and physiological function [5]. It has also been proposed to lessen or prevent female reproductive disorders [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial

Sarebani¹,

Chegini²,

Chen³

et al. 2023

Obstet Gynecol Sci

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“…Another randomized controlled trial found that participants received vitamin D experienced signi cant reduction in menstrual pain, and the consumed painrelief medications [4].…”

Section: Discussionmentioning

confidence: 99%

“…Increased local prostaglandins with a subsequent increased amplitude of uterine contractions, and endometrial ischemia is the most accepted theory of primary dysmenorrhea [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The impact of primary dysmenorrhea on the adolescents` activities and school attendance

Donayeva

Amanzholkyzy

Nurgaliyeva

et al. 2023

Preprint

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Background: The primary dysmenorrhea is the most prevalent menstrual problem in adolescence, which affects their daily activities, and it is the most common cause of adolescents` school absenteeism. Objectives: To detect the impact of primary dysmenorrhea on the adolescents` activities, and school attendance. Methods: One hundred and eighty (180) adolescents between 12-18 years-old with primary dysmenorrhea were included in this study. After thorough evaluation, a trans-abdominal pelvic ultrasound was done for the studied participants to exclude any pelvic pathology. The severity of the participants’ dysmenorrhea was assessed using the visual analogue scale (VAS). Participants were categorized based on the VAS into, mild dysmenorrhea (VAS 1-3), moderate dysmenorrhea (VAS 4-7), and severe dysmenorrhea (8-10) groups. Participants were asked whether the dysmenorrhea based on its severity (i.e., mild (VAS 1-3), moderate (VAS 4-7), or severe (VAS 8-10)), negatively affect their physical, and social activities, or their school attendance or not. The one-way ANOVA test was used to compare between the studied groups. The Pearson`s correlation was used to detect the relation between the severity of dysmenorrhea, and its negative impact on the adolescents’ activities, and school attendance. Results: There was a significant positive correlation between the severity of dysmenorrhea, and its negative impact on the adolescents’ physical activities (r = 0.395; P<0.00001), and between the severity of dysmenorrhea, and its negative impact on the adolescents’ social activities (r = 0.658; P<0.00001). There was also a significant positive correlation between the severity dysmenorrhea and its negative impact on the adolescents’ school attendance (r = 0.416; P<0.00001). Conclusion: The odds of negative impact of dysmenorrhea on the adolescents` physical, and social activities, and on their school, attendance were significantly higher in adolescents suffering from moderate, and severe dysmenorrhea compared to adolescents with mild dysmenorrhea.

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“…In women with primary dysmenorrhea without the diagnosis of endometriosis different dosages (single 300.000 IU dose 5 days before menstruation [ 40 , 41 ] or 50.000 IU/ weekly [ 42 , 43 ]) of vit D supplementation can reduce pain intensity. A significantly greater mean decrease in pain has been also observed in a systematic meta-analysis evaluating vit D supplementation in patients with different kinds of pain (musculosceletal pain, arthritis, dysmenorrhea, migraine) xxx (mean difference -0.57, 95% CI: -1.00 to -0.15, P = 0.007) [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D supplementation in endometriosis: a systematic review

Kalaitzopoulos

Samartzis

Daniilidis

et al. 2022

Reprod Biol Endocrinol

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Background There is a growing body of human, animal and in vitro studies on vitamin D (vit D) substitution in endometriosis. The aim of this systematic review is to critically appraise and qualitatively synthesize the results of the available studies that examine the supplementation of vit D for endometriosis treatment. Methods A systematic search of the literature was conducted in four electronic databases (Medline, Cochrane, Scopus, Embase) and grey literature for original research articles on humans, animals and in vitro models published in any language. Results Four human studies, four animal studies and four in vitro studies were included. Quantitative synthesis of human studies showed no significant effect of vit D intake for dysmenorrhea (2 studies, 44 vit D vs 44 placebo, mean -0.71, 95% CI -1.94, 0.51) and non-cyclic pelvic pain (2 studies, 42 vit D vs 38 placebo, mean 0.34, 95% CI -0.02, 0.71). Regarding reproductive outcomes in women with endometriosis after in vitro fertilization, the only available study showed no differences between women taking vit D and women taking placebo. Three of the four included animal studies showed regression of endometriotic implants when treated with vit D. The in vitro studies demonstrated that vit D decreases invasion and proliferation of endometriotic lesions without affecting apoptosis. Conclusions Although in vitro and animal studies suggest regression of the endometriotic implants and decrease of invasion and proliferation after vit D supplementation, this was not reflected in the results of the meta-analysis, which showed no benefit of vit D supplementation in patients with endometriosis and dysmenorrhea or non-cyclic pelvic pain as well as on the outcome of IVF treatment. However, given the heterogeneity and the diversity of the available studies, more research is required to shed light on the role of vit D supplementation in women with endometriosis.

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Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial

Cited by 22 publications

References 33 publications

Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial

Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial

The impact of primary dysmenorrhea on the adolescents` activities and school attendance

Effects of vitamin D supplementation in endometriosis: a systematic review

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