Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis

Ashour, Hend; Gamal, Sara Mahmoud; Sadek, Nermeen Bakr; Rashed, Laila Ahmed; Hussein, Rania Elsayed; Kamar, Samaa S; Ateyya, Hayam; Mehesen, Marwa Nagi; ShamsEldeen, Asmaa Mohammed

doi:10.3389/fphys.2021.744548

Cited by 6 publications

(4 citation statements)

References 58 publications

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“…This effect is achieved by binding to its VDRs receptor on the endometrium, which in turn increases the expression of the HOXA10 gene, a crucial gene involved in both placentation and implantation [ 50 , 51 ]. In a rat model, supplementation of VD positively influenced the proper endometrial priming required for successful implantation and the continuation of pregnancy by enhancing progesterone and HOXA 10 expression [ 52 ]. Indeed, after VD administration, an increase in HOXA-10 was observed together with an improvement in endometrial decidualization in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Baldini,

Russo,

Proietti

et al. 2024

Arch Gynecol Obstet

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Purpose The study aims to demonstrate the effects of Vitamin D (VD) supplementation, prior to oocyte pick-up within IVF protocols, in women with diverse VD status at the enrollment. Methods A total of 204 women eligible for intra-cytoplasmatic sperm injection (ICSI) cycles were included in the study and two homogeneous groups were selected from the database. Both group of patients with normal VD baseline level (> 40 ng/ml) and patients with low VD baseline level (< 20 ng/ml) were divided into control group and treatment group. The control group followed the standard procedure. The treatment group was supplemented with vitamin D3 as cholecalciferol in combination with Myo-Inositol, folic acid, and melatonin 3 months before standard procedure, once a day in the evening. Results VD levels significantly increased in the study group of low baseline VD, both in serum and in the follicular fluid compared to controls. The treatment induced a significant improvement of the embryo quality in both group of patients considered. Conclusion Supplementation of VD in patients undergoing ICSI procedures significantly improved the number of top-quality embryos compared with the control group, either starting from VD normal baseline values or starting from low values. Trial registration number 07/2018.

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Section: Discussionmentioning

confidence: 99%

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Baldini,

Russo,

Proietti

et al. 2024

Arch Gynecol Obstet

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“…In support of the role of VD sufficiency during IVF procedures, one study detected higher pregnancy rate during IVF procedures in women showing higher endometrial VD receptor (VDR) expression levels, especially during the implantation window of the menstrual cycle than in women with decreased expression [23] . Another study found VD supplemental therapy (VDST) increased serum vitamin D3 levels with subsequent higher implantation rates during IVF [24] . Recently, a widepopulation study of women undergoing ICSI detected a positive correlation between basal serum levels of 25-OHVD and basal levels of follicle-stimulating hormone, estradiol, anti-Müllerian hormone, antral follicle count, and a number of the retrieved oocytes [19] .…”

Section: Discussionmentioning

confidence: 99%

Interaction of Vitamin D and Tumor Necrosis Factor-α can modulate the Outcomes of ICSI

Bendary,

Marie,

Elnajar

2023

Evidence Based Women's Health Journal

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Objective: To investigate the relation between vitamin D sufficiency (VDS) levels and outcomes of ICSI for infertile women. Materials and Methods: 104 infertile women were clinically evaluated and given blood samples for estimation of serum levels of tumor necrosis factor-α (TNF-α) and 25-Hydroxy VD (25-OHVD) and were categorized according to VDS levels. All women underwent frozen embryo transfer after controlled ovarian stimulation. The chemical (CPR) and clinical pregnancy rates (CLPR), the early pregnancy loss (EPL), and the successful pregnancy rate (SPR) were evaluated concerning the estimated levels of 25-OHVD and TNF-α. Results:The CPR was 53.8% and was higher among VD deficient (VDD) women. The CLPR was 36.5% and showed an insignificant difference according to VDS status. The EPR was 20.2%, while the SPR was 16.3% and was significantly higher in VDS than in VDD women. There was a negative significant correlation between serum levels of 25-OHVD and TNF-α. The CPR and CLPR showed negative significant correlations with serum TNF-α levels. The SPR showed positive and negative significant correlations with serum levels of 25-OHVD and TNF-α, respectively. Conclusion: VD might improve ICSI outcomes through its modulatory action on the systemic inflammatory milieu. Proinflammatory cytokines had deleterious effects on ICSI outcomes and the balance between pre-and anti-inflammatory cytokines must be corrected before committing ART procedures.

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“…In a cross-sectional study, the values of 25(OH)D and endometrial thickness were significantly increased in the pregnancy group after intracytoplasmic sperm injection, suggesting that 25(OH)D deficiency in women could affect endometrial thickness [ 190 ]. Ashour et al [ 191 ] supplemented vitamin D to a rat model of vitamin D deficiency and found that vitamin D improved the endometrial receptivity of rats by adjusting the expression of HOXA-10. Additionally, a systematic review has investigated the relationship between vitamin D and the success rate of embryo transfer, and found that women with more adequate vitamin D showed higher clinical pregnancy rate and that higher vitamin D levels could improve the success rate of ART [ 192 ].…”

Section: Methodsmentioning

confidence: 99%

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Recently, with the development of the social economy, the incidence of infertility has increased year by year. With its complex etiology and diversified syndromes, infertility has become one of the most important diseases that plague the physical and mental health of women of childbearing age worldwide. Endometrial factors as an important part affecting female reproductive capacity, due to which induced repeated abortion and multiple uterine cavity operations occur, can destruct endometrium, failing to provide a normal implantation environment for zygote, thus resulting in infertility. Many patients failed to achieve expected results after receiving conventional treatments such as hormone therapy, assisted reproductive technology (ART), granulocyte colony-stimulating factor (G-CSF) therapy, and cell therapy, then turn to complementary and alternative medicine (CAM) therapies for help. Aiming at clarifying the effectiveness and mechanisms of CAM therapy in the treatment of infertility caused by endometrial factors, our paper systematically searched and studied present related literature on the PubMed, CNKI, and other databases, focusing on the aspects of clinical application and mechanism explorations and highlighting the therapeutic effects of Chinese herbal medicine (CHM), acupuncture, and moxibustion on such diseases. Moreover, this paper also introduces the CAM treatments of traditional Chinese medicine (TCM) retention enema, neuromuscular electrical stimulation (NMES), photobiomodulation therapy, dietary intervention, and other measures for infertility caused by endometrial factors, in order to provide a reference for subsequent basic research and clinical work.

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Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis

Cited by 6 publications

References 58 publications

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Interaction of Vitamin D and Tumor Necrosis Factor-α can modulate the Outcomes of ICSI

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

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