Vitamin D supplementation to prevent vitamin D deficiency for children with epilepsy

Khalifah, Reem Al; Hudairi, Abrar; Homyani, Doua Al; Hamad, Muddathir H.; Bashiri, Fahad A.

doi:10.1097/md.0000000000012734

Cited by 21 publications

(16 citation statements)

References 36 publications

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“…Khalifah et al studied the effectiveness of vitamin D supplementation in preventing vitamin D deficiency in high-risk patients. 31 We believe these findings might influence our practice in the near future.…”

Section: Discussionmentioning

confidence: 90%

Association between serum vitamin D levels and age in patients with epilepsy: a retrospective study from an epilepsy center in Saudi Arabia

et al. 2022

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BACKGROUND: Vitamin D deficiency has been linked to various medical conditions such as bone loss, decreased mineralization, endocrine disorders, and central nervous system disorders, including epilepsy. Vitamin D deficiency is prevalent among patients with epilepsy (PWE). However, the specific association between vitamin D levels and age in PWE is unclear. OBJECTIVES: Identify the relation between vitamin D level and age in PWE and evaluate factors that may play a role in seizure control. DESIGN: Retrospective analytical medical record review SETTING: Outpatient epilepsy research clinic in Saudi Arabia PATIENTS AND METHODS: Between November 2016 and April 2020, we selected eligible PWE aged older than 14 years whose vita-min D levels were recorded at least once after reviewing 1550 patient electronic files. We analyzed data on serum vitamin D level by age and other factors, vitamin D supplement use, seizure classification, and conducted a multivariate logistic regression to assess associations with seizure control. MAIN OUTCOME MEASURES: Relationships between vitamin D levels and age and factors that might affect seizure control. SAMPLE SIZE: 524 patients RESULTS: The prevalence of low serum vitamin D levels was high (86.8%). The median vitamin D level in all patients was low (38 nmol/L), and was lower in young PWE than in adult PWE ( P <.01). Only 146 patients received vitamin D supplements. High vitamin D levels were associated with a 40% seizure reduction. CONCLUSION: Vitamin D deficiency is underestimated in PWE in Saudi Arabia, and is more prevalent among young adults and patients on polytherapy than in other PWE. Patients with high vitamin D levels had good seizure control compared with those with low levels. The effect of vitamin D supplements on seizure control should be further investigated in randomized control trials. LIMITATIONS: Retrospective study and no categorization by presence of supplementation. CONFLICT OF INTEREST: None.

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Section: Discussionmentioning

confidence: 90%

Association between serum vitamin D levels and age in patients with epilepsy: a retrospective study from an epilepsy center in Saudi Arabia

et al. 2022

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“…We suspect this was caused by the interference in vitamin D absorption that some antiseizure medications can produce [11]. Correction of vitamin D deficiency has been shown to lower the frequency of seizure, especially in younger epilepsy patients [12,13].…”

Section: Therapeutic and Dietary Recommendationsmentioning

confidence: 97%

Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe Epilepsy

Garg¹,

Koche²,

Mehdi³

2020

Preprint

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A 12 year old boy was diagnosed with temporal lobe epilepsy (TLE) along with mesial temporal sclerosis based on MRI (magnetic resonance imaging) results. The diagnosis was further confirmed by genetic analysis. He also had minor psychiatric symptoms of obsessive-compulsive disorders and mood swings. After 4 years of treatment with Sodium Valproate no change in symptoms was observed. Genetic testing along with deep phenotyping revealed altered glutamate pathway and metabolism. Post genetic testing the patient was put on a combination of Sodium Valproate and Valproic acid along with supplementation of N-acetylcysteine (NAC), Cyanocobalamin, Pyridoxine and Cholecalciferol. Within three months of this combined therapy the patient experienced complete elimination of seizures and drastic improvement in mood and social behaviour. The case report highlights the importance of precision diagnosis in understanding the underlying perturbed pathways in structural epilepsy like TLE and demonstrates the importance of non-invasive targeted therapy in such cases.

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“…Vitamin D may affect the seizures by maintaining the neuromediator genes' expression as they take part in the neurotransmission. Furthermore, Vitamin D, being a neurosteroidal agent, may directly interact with GAB A A brain receptors (GABA A R) [45].…”

Section: Epileptic Seizuresmentioning

confidence: 99%

Вітамін-D-Статус У Пацієнтів Із Транзиторними Втратами Свідомості Нетравматичного Генезу (Огляд Літератури)

Kovalchuk¹,

Boyarchuk²

2021

PJS

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The article presents an analysis of the recent scientific findings on vitamin D status in patients with different etiopathogene tic varieties of nontraumatic transient loss of consciousness. The results of recent researches suggest that vitamin D may play an indirect and, in some cases, direct role in the pathogenesis of nontraumatic transient loss of consciousness. Data on the causeeffect relationship between a low vitamin D status and syncope are mixed, controversial and ambiguous, which is largely due to the use of different doses of vitamin D, its initial concentration, duration of therapy, genetic diffe rences in the vitamin D receptors, different age groups, physical parameters of the surveyed, medications, peculiarities of nutrition with special supplements, differences in physical activity, peculiarities of the climate and season, and others. Until now there is no convincing evidence of the benefits of using vitamin D in the treatment and prevention of syncope. Most studies are observational and relate mainly to adult populations. Therefore, randomized controlled studies focused on children may be a promising field of research.

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Vitamin D supplementation to prevent vitamin D deficiency for children with epilepsy

Abstract: Supplemental Digital Content is available in the text

Cited by 21 publications

References 36 publications

Association between serum vitamin D levels and age in patients with epilepsy: a retrospective study from an epilepsy center in Saudi Arabia

Association between serum vitamin D levels and age in patients with epilepsy: a retrospective study from an epilepsy center in Saudi Arabia

Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe Epilepsy

Вітамін-D-Статус У Пацієнтів Із Транзиторними Втратами Свідомості Нетравматичного Генезу (Огляд Літератури)

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