Vitamin D2 from light-exposed edible mushrooms is safe, bioavailable and effectively supports bone growth in rats

Calvo, Mona S.; Babu, Uma S.; Garthoff, Larry H.; Woods, Terry O.; Dreher, Maureen L.; Hill, Genevieve; Nagaraja, Srinidhi

doi:10.1007/s00198-012-1934-9

Cited by 49 publications

(44 citation statements)

References 37 publications

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“…Mushrooms also exhibit ergosterol which can be converted to vitamin D2 when exposed to UV light. In animal experiments using ergocalciferol-enriched mushroom powder, an increase in hydroxyvitamin D and bone mineralization was observed [9,10]. Selenium content in mushrooms varies according to the form of cultivation, soil selenium content, and latitude.…”

Section: Chemical and Nutritional Aspects Of Edible Mushroomsmentioning

confidence: 99%

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Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action

Figueiredo

Régis

2017

Nutrire

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Mushrooms have been used for centuries as a source of nourishment and sensory properties. Mushrooms are considered functional foods due to their bioactive compounds and a source of drug and nutraceutical development. More than 50 species present immunological potential that exhibit anticancer activity in vitro or in animal models, and some of them have been investigated in human cancers. Cancer is a major cause of death all over the world, promoting long lasting effects throughout the lifetime of the patient. Mushrooms are a source of ergothioneine, selenium, fiber, and several other vitamins and minerals. They have bioactive compounds used in cancer treatment due to their antitumor and anticarcinogenic effects. They contain β-glucans, β-proteoglycans, lectins, triterpenes, ergosterol, glutamine, and arginine. In the present study, we perform a literature review of studies that analyze positive impacts of mushroom compounds on cancer treatment due to their antitumor and anticarcinogenic effects and possible compatibility with chemotherapy management. The review indicates that a healthy diet with frequent consumption of mushrooms apparently reduces the risk of developing cancer. However, a clearer understanding of how mushrooms' bioactive principles may affect adjuvant treatments requires further research with long-term double-blind and placebo-controlled studies that evaluate a larger population in clinical trials by each type of cancer. Therefore, more robust statistical results are necessary to verify their efficacy and safety on cancer treatments.

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Section: Chemical and Nutritional Aspects Of Edible Mushroomsmentioning

confidence: 99%

“…Selenium is an essential micronutrient that plays a key role in cell cycle and apoptosis. Marginal selenium deficiency may contribute to the reduction of immune function in some types of cancer [10][11][12].…”

Section: Chemical and Nutritional Aspects Of Edible Mushroomsmentioning

confidence: 99%

Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action

Figueiredo

Régis

2017

Nutrire

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“…Cultivated white button mushrooms provide high concentrations of vitamin D 2 from ergosterol upon exposure to ultraviolet B (UVB) light. [17][18][19][20][21][22] UVB-exposed edible white button mushrooms have been shown in chronic rodent feeding studies to be a safe and effective source of vitamin D 2 , which is functional in support of growing bone and beneficially modulates immune response. 18,19 In young adult men and women, mushroom-D 2 effectively increases 25OHD 2 in D-deficient young adults consuming capsules of dried extracts of UVB-exposed white button mushrooms (daily) 20 or in D-replete or insufficient young adults, fed soups containing moderate (daily) or very high concentrations of D 2 (once weekly).…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20][21][22] UVB-exposed edible white button mushrooms have been shown in chronic rodent feeding studies to be a safe and effective source of vitamin D 2 , which is functional in support of growing bone and beneficially modulates immune response. 18,19 In young adult men and women, mushroom-D 2 effectively increases 25OHD 2 in D-deficient young adults consuming capsules of dried extracts of UVB-exposed white button mushrooms (daily) 20 or in D-replete or insufficient young adults, fed soups containing moderate (daily) or very high concentrations of D 2 (once weekly). 21,22 The addition of UVB-treated mushrooms to processed foods, such as canned soup in Canada, or the consumption of fresh D 2-enhanced mushrooms, currently marketed across the United States, is now promoted as an effective strategy for increasing the vitamin D intake in the general US population.…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of vitamin D2 from enriched mushrooms in prediabetic adults: a randomized controlled trial

et al. 2014

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“…We choose Pleurotus ferulae as the mushroom of choice to deliver vitamin D 2 to ovariectomized (OVX) mice, as this species produces the highest vitamin D 2 compared with other oyster mushrooms when irradiated. Vitamin D 2 from UVB-light-exposed edible mushrooms has been shown to be both bioavailable and safe in humans [15].…”

Section: Introductionmentioning

confidence: 99%

Consumption of vitamin D2 enhanced mushrooms is associated with improved bone health

Chen

Kao

et al. 2015

The Journal of Nutritional Biochemistry

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Mushrooms are the best nonanimal food source of vitamin D2. Pulsed irradiation can enhance vitamin D2 in mushrooms quickly. We investigated the effect of supplementing high vitamin D2Pleurotus ferulae mushrooms in a mouse model of osteoporosis. Thirty-two female C57BL/6JNarl mice were divided into four groups including sham, ovariectomized (OVX), OVX+nonpulsed mushroom (NPM) and OVX+pulsed mushroom (PM). After 23 weeks of treatment, serum samples were analyzed for osteoblast and osteoclast indicators, as well as metabolites using NMR spectroscopy. To examine bone density, femurs were analyzed using micro-computed tomography. The NPM and PM treatment mice showed increased bone density in comparison with OVX mice. In addition, the PM mice showed higher osteoblast and lower osteoclast indicators in comparison with OVX mice. Serum metabolomics analysis indicated several metabolites that were different in PM mice, some of which could be correlated with bone health. Taken together, these results suggest that pulsed irradiated mushrooms are able to increase bone density in osteoporotic mice possibly through enhanced bone metabolism. Further studies in humans are needed to show their efficacy in preventing osteoporosis.

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Vitamin D2 from light-exposed edible mushrooms is safe, bioavailable and effectively supports bone growth in rats

Abstract: Vitamin D(2) from UVB-exposed mushrooms is bioavailable, safe, and functional in supporting bone growth and mineralization in a growing rat model without evidence of toxicity.

Cited by 49 publications

References 37 publications

Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action

Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action

Bioavailability of vitamin D2 from enriched mushrooms in prediabetic adults: a randomized controlled trial

Consumption of vitamin D2 enhanced mushrooms is associated with improved bone health

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