Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells

Grund, Janina C.; Krammer, Susanne; Yang, Zuqin; Mitländer, Hannah; Rauh, Manfred; Zirlik, Sabine; Krause, Alexander; Zimmermann, Theodor; Rieker, Ralf J.; Geppert, Carol I.; Papadopoulos, Nikolaos G.; Finotto, Susetta

doi:10.1016/j.jacig.2023.100099

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…This bidirectional action of vitamin D on the innate IS also occurs in innate lymphoid cells (ILCs). While in some scientific works, vitamin D is found to be important for the cytokine response of ILCs to infectious processes [32], in others it has an anti-inflammatory or antagonistic effect in this sense [33,34].…”

Section: Vitamin D and The Gut Microbiome In Immunomodulationmentioning

confidence: 99%

Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Murdaca,

Tagliafico,

Page

et al. 2024

Biomedicines

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The synergic role of vitamin D and the intestinal microbiota in the regulation of the immune system has been thoroughly described in the literature. Vitamin D deficiency and intestinal dysbiosis have shown a pathogenetic role in the development of numerous immune-mediated and allergic diseases. The physiological processes underlying aging and sex have proven to be capable of having a negative influence both on vitamin D values and the biodiversity of the microbiome. This leads to a global increase in levels of systemic inflammatory markers, with potential implications for all immune-mediated diseases and allergic conditions. Our review aims to collect and analyze the relationship between vitamin D and the intestinal microbiome with the immune system and the diseases associated with it, emphasizing the effect mediated by sexual hormones and aging.

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Section: Vitamin D and The Gut Microbiome In Immunomodulationmentioning

confidence: 99%

Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Murdaca,

Tagliafico,

Page

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review

Ghaseminejad-Raeini,

Ghaderi,

Sharafi

et al. 2023

Front. Immunol.

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For many years, vitamin D has been acknowledged for its role in maintaining calcium and phosphate balance. However, in recent years, research has assessed its immunomodulatory role and come up with conflicting conclusions. Because the vitamin D receptor is expressed in a variety of immune cell types, study into the precise role of this molecule in diseases, notably autoimmune disorders, has been made possible. The physiologically activated version of vitamin D also promotes a tolerogenic immunological condition in addition to modulating innate and acquired immune cell responses. According to a number of recent studies, this important micronutrient plays a complex role in numerous biochemical pathways in the immune system and disorders that are associated with them. Research in this field is still relatively new, and some studies claim that patients with severe autoimmune illnesses frequently have vitamin D deficiencies or insufficiencies. This review seeks to clarify the most recent research on vitamin D’s immune system-related roles, including the pathophysiology of major disorders.

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Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells

Cited by 2 publications

References 51 publications

Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review

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