Vitamin E and adiponectin: proposed mechanism for vitamin E-induced improvement in insulin sensitivity

Gray, Brianna; Swick, Jennifer; Ronnenberg, Alayne G.

doi:10.1111/j.1753-4887.2011.00377.x

Cited by 44 publications

(38 citation statements)

References 51 publications

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“…Inhibition of tau aggregation may be an efficient strategy to inhibit sequestration of APN by tau, and a clinical study of tau immunization for progressive supranuclear palsy is ongoing 68. However, stimulating endogenous production of APN using compounds such as PPAR‐ γ agonists,69 acetylcholinesterase inhibitors,70 and vitamin E71 may be detrimental in terms of the toxic gain of function of APN.…”

Section: Apn As a Novel Target For Therapies For Admentioning

confidence: 99%

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Waragai

Ho²,

Takamatsu

et al. 2017

Ann Clin Transl Neurol

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A recent study suggested that insulin resistance may play a central role in the pathogenesis of Alzheimer's disease (AD). In this regard, it is of note that upregulation of plasma adiponectin (APN), a benign adipokine that sensitizes the insulin receptor signaling pathway and suppresses inflammation, has recently been associated with the severities of amyloid deposits and cognitive deficits in the elderly, suggesting that APN may enhance the risk of AD. These results are unanticipated because AD has been linked to type II diabetes and other metabolic disorders in which hypoadiponectinemia has been firmly established, and because APN ameliorated neuropathological features in a mouse model of neurodegeneration. Therefore, the objective of this study is to discuss the possible mechanisms underlying the biological actions of APN in the context of AD. Given that insulin receptor signaling is required for normal function of the nervous system, we predict that APN may be upregulated to compensate for compromised activity of the insulin receptor signaling pathway. However, increased APN might be sequestered by tau in the brain, leading to neurotoxic protein aggregation in AD. Alternatively, misfolding of APN may result in downregulation of the insulin/APN signal transduction network, leading to decreased neuroprotective and neurotrophic activities. Thus, it is possible that both ‘gain of function’ and ‘loss of function’ of APN may underlie synaptic dysfunction and neuronal cell death in AD. Such a unique biological mechanism underlying APN function in AD may require a novel therapeutic strategy that is distinct from previous treatment for metabolic disorders.

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Section: Apn As a Novel Target For Therapies For Admentioning

confidence: 99%

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Waragai

Ho²,

Takamatsu

et al. 2017

Ann Clin Transl Neurol

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“…43,44 Another major target of ROS is the inflammatorymediated transcription factor called NFkB. [45][46][47] During the inflammatory stage, wounded tissue secretes growth factors and cytokines for initiation of healing process. Neutrophils phagocytize cell debris and bacteria and gradually replace monocytes with macrophages.…”

Section: 41mentioning

confidence: 99%

Gamma-tocopherol supplementation ameliorated hyper-inflammatory response during the early cutaneous wound healing in alloxan-induced diabetic mice

Shin

Yang

Lim

2016

Exp Biol Med (Maywood)

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Gamma tocopherol has shown ameliorative effect on diabetic wound healing by regulation of inflammation, oxidative stress, and apoptosis demonstrated by nuclear factor kappa B, nuclear factor (erythroid derived 2)-like 2, and sirtuin-1. AbstractDelayed wound healing is one of the major diabetic complications. During wound healing process, the early inflammatory stage is important for better prognosis. One of antioxidant nutrient, gamma-tocopherol (GT) is considered to regulate inflammatory conditions. This study investigated the effect of GT supplementation on mechanism associated with inflammation, oxidative stress, and apoptosis during early cutaneous wound healing in diabetic mice. Diabetes was induced by alloxan injection in ICR mice. All mice were divided into three groups: non-diabetic control mice (CON), diabetic control mice (DMC), and diabetic mice supplemented with GT (GT). After two weeks of GT supplementation, excisional wounds were made by biopsy punches (4 mm). Diabetic mice showed increases in fasting blood glucose (FBG) level, hyper-inflammatory response, oxidative stress, and delayed wound closure rate compared to non-diabetic mice. However, GT supplementation reduced FBG level and accelerated wound closure rate by regulation of inflammatory response-related proteins such as nuclear factor kappa B, interleukin-1b, tumor necrosis factor-a, and c-reactive protein, and oxidative stress-related markers including nuclear factor (erythroid derived 2)-like 2, NAD(P)H dehydrogenase quinone1, heme oxygenase-1, manganese superoxide dismutase, catalase and glutathione peroxidase and apoptosis-related markers such as sirtuin-1, peroxisome proliferator-activated receptor gamma coactivator 1-, and p53 in diabetic mice. Taken together, GT would be a potential therapeutic to prevent diabetes-induced delayed wound healing by regulation of inflammatory response, apoptosis, and oxidative stress.

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“…Hence it is used as fodder or for oil production (Appett 1986). These byproducts contain valuable fat-soluble substances such as tocopherols, sterols, carotenoids, steryl ferulates and others having biological effects (Wilson et al 2007;Agudo et al 1999;Gray et al 2010). At present these are going as waste and their application in food industry need to be explored.…”

Section: Introductionmentioning

confidence: 99%

“…Lutein and zeaxanthin are the carotenoids, especially abundant in retina (macula) which can prevent development of macular degeneration at the older age (Olmedilla et al 2001). Tocopherols exhibit vitamin E activity and also other biological activities such as, anti-diabetic property by improving insulin sensitivity (Gray et al 2010) and anti-cancerous activity (Yang et al 2011). Extensive studies have been carried out on tocopherols in wheat germ oil but not much work has been done on carotenoids and oryzanol in wheat germ oil (WGO) and wheat bran oil (WBO).…”

Section: Introductionmentioning

confidence: 99%

Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil

Kumar

Krishna

2013

J Food Sci Technol

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Fat-soluble nutraceuticals of cereals are known for number of disease preventive activities. Hence wheat bran oil (WBO) and wheat germ oil (WGO) were extracted from wheat bran and germ which yielded 3.35 % and 7.35 % of oil, containing polyunsaturated fatty acids (PUFA) (64 %, 61.2 %) respectively. Both oils contained tocopherols and carotenoids, which were higher in wheat germ oil (273 mg/ 100 g, 12.23 mg/100 g) than wheat bran oil (190 mg/100 g, 2.21 mg/100 g). Steryl ferulates were also present in both the oils, but their content was eight-fold higher in WBO than in WGO. Three major steryl ferulates identified by HPLC were campesteryl ferulate and sitostenyl ferulate, campestanyl ferulate and β-sitosteryl ferulate as in γ-oryzanol and another ferulate, viz., sitostanyl ferulate. A strong IC 50 value of 7.5 mg/mL and 21.6 mg/mL DPPH free radicals scavenging for wheat germ oil for wheat bran oil was observed. NMR ( 13 C and 1 H) profile explored the evidence of distribution of antioxidant molecules in the unsaponifiable matter of wheat derived oil. Since oils rich in PUFA and minor components are required for the normal physiological activities, blending such oils with other edible oils of the diet in wheat growing countries like India may be useful to provide health benefits.

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Vitamin E and adiponectin: proposed mechanism for vitamin E-induced improvement in insulin sensitivity

Cited by 44 publications

References 51 publications

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Gamma-tocopherol supplementation ameliorated hyper-inflammatory response during the early cutaneous wound healing in alloxan-induced diabetic mice

Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil

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