Vitamin E and conflicting understandings in noncommunicable diseases: Is it worth supplementing?

Trugilho, Liana; Alvarenga, Livia; Cardozo, Ludmila FMF.; Barboza, Isis; Leite, Maurilo; Fouque, Denis; Mafra, Denise

doi:10.1016/j.clnesp.2023.12.147

Clinical Nutrition ESPEN

2024

DOI: 10.1016/j.clnesp.2023.12.147

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Vitamin E and conflicting understandings in noncommunicable diseases: Is it worth supplementing?

Liana Trugilho,

Livia Alvarenga,

Ludmila FMF. Cardozo

et al.

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Cited by 4 publications

References 105 publications

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The E‐volution in swine nutrition: Current perspectives on vitamin E

Shastak,

Pelletier

2024

Animal Research and One Health

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This review provides an in‐depth analysis of vitamin E's multifaceted role in swine nutrition, incorporating both traditional insights and contemporary research. It begins with an exploration of vitamin E from an evolutionary perspective, followed by a detailed examination of its absorption, metabolism, and excretion in swine. The review emphasizes the micronutrient's critical functions in swine physiology, particularly its antioxidant properties and its emerging links to epigenetics, which include deoxyribonucleic acid methylation, histone modification, and noncoding ribonucleic acid regulation. The interactions of vitamin E with other dietary components are discussed, along with established nutritional requirements and current recommendations for supplementation. Additionally, the health benefits and performance improvements associated with vitamin E are presented, emphasizing its importance in immune function, growth, and meat quality. Despite extensive research, the review identifies gaps in understanding the bioavailability and long‐term impacts of different vitamin E isoforms and supra‐nutritional supplementation levels. It concludes with a discussion of research gaps and future directions, particularly the need for studies on the long‐term effects of high‐dose vitamin E supplementation and the influence of environmental factors on its metabolism. Through this comprehensive synthesis, this study aims to provide a holistic understanding of vitamin E's essential contributions to swine health and nutrition, with the goal of informing better dietary practices and enhancing swine productivity.

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The E‐volution in swine nutrition: Current perspectives on vitamin E

Shastak,

Pelletier

2024

Animal Research and One Health

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Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003–2018 data

Zeng,

Liao,

et al. 2025

International Journal of Cardiology Cardiovascular Risk and Pre

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The Interplay between Liver and Adipose Tissue in the Onset of Liver Diseases: Exploring the Role of Vitamin Deficiency

Tattoli,

Mathew,

Verrienti

et al. 2024

Cells

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The deficiency of vitamins, a condition known as “hidden hunger”, causes comprehensive pathological states. Research over the years has identified a relationship between liver diseases and hypovitaminosis or defects in vitamin metabolism. The exact mechanisms remain elusive; however, the crucial involvement of specific vitamins in metabolic functions, alongside the reclassification of liver disease as metabolic dysfunction-associated steatotic liver disease (MASLD), has prompted researchers to investigate the potential cause-effect dynamics between vitamin deficiency and liver disease. Moreover, scientists are increasingly investigating how the deficiency of vitamins might disrupt specific organ crosstalk, potentially contributing to liver disease. Although the concept of a dysmetabolic circuit linking adipose tissue and the liver, leading to liver disease, has been discussed, the possible involvement of vitamin deficiency in this axis is a relatively recent area of study, with numerous critical aspects yet to be fully understood. In this review, we examine research from 2019 to July 2024 focusing on the possible link between liver-adipose tissue crosstalk and vitamin deficiency involved in the onset and progression of non-alcoholic fatty liver disease (NAFLD). Studies report that vitamin deficiency can affect the liver-adipose tissue axis, mainly affecting the regulation of systemic energy balance and inflammation.

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Vitamin E and conflicting understandings in noncommunicable diseases: Is it worth supplementing?

Cited by 4 publications

References 105 publications

The E‐volution in swine nutrition: Current perspectives on vitamin E

The E‐volution in swine nutrition: Current perspectives on vitamin E

Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003–2018 data

The Interplay between Liver and Adipose Tissue in the Onset of Liver Diseases: Exploring the Role of Vitamin Deficiency

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