Vitamin E reduces the extent of mouse brain damage induced by combined exposure to formaldehyde and PM2.5

Li, Xudong; Zhang, Yuchao; Yang, Xu

doi:10.1016/j.ecoenv.2019.01.048

Cited by 18 publications

(4 citation statements)

References 13 publications

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“…Dietary inclusion of natural products or natural origin commercial supplements with antioxidant properties is very common nowadays because it has been shown that numerous diseases can appear due to the oxidative stress process. For example, vitamin E has been proposed as a beneficial food supplement to counteract the FAinduced effects or by other xenobiotics due to its multiple antioxidant qualities [35]. Some authors have published important findings about vitamin E, highlighting its effect on sperm parameters improvement (motility, viability, and concentration) [36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Hedeoma drummondii against Formaldehyde-Induced Testicular Toxicity and Genotoxicity in Wistar Rats

Betancourt-Martínez,

Carranza-Rosales,

Viveros-Valdez

et al. 2023

Andrologia

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Formaldehyde (FA) is an oxidative stress inducer and a known carcinogen. Hedeoma drummondii has been shown to have potential as a chemopreventive agent. The aim of this study was to assess the protective effect of H. drummondii on FA-induced genotoxic damage, sperm quality parameters, and histological changes of the testis. The male Wistar rats used were divided into the following groups: (G1) 100 mg/kg H. drummondii; (G2) 10 mg/kg FA; (G3) 100 mg/kg H. drummondii + 10 mg/kg FA; (G4) phosphate-buffered saline; (G5) 100 mg/kg α-tocopherol; (G6) 100 mg/kg α-tocopherol + 10 mg/kg FA; and (G7) soybean oil. The results showed a sperm concentration of 23.66 ± 1.52 versus 33.67 cells/mL ( p = 0.02 ), and a percentage of motility of 29.66 ± 1.51 versus 33.33 ( p = 0.620 ), for groups G3 and G6, respectively. Histopathological (H&E) and immunohistochemical analysis of superoxide dismutase showed damage in the germinal epithelium (GE) in G2. While in groups G3 and G6, the histological structure was preserved. A protective effect on sperm DNA fragmentation was also observed for treated groups (G3 and G6, p < 0.0001 vs. G2). While in groups G3 and G6 the histological structure was preserved. A protective effect on sperm DNA fragmentation was also observed for treated groups (G3 and G6). In conclusion, FA exposure significantly reduces sperm quality parameters, causes sperm DNA damage, and alters GE in the testis, while H. drummondii has a protective effect against FA-induced sperm genotoxic damage, similar to α-tocopherol.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Hedeoma drummondii against Formaldehyde-Induced Testicular Toxicity and Genotoxicity in Wistar Rats

Betancourt-Martínez,

Carranza-Rosales,

Viveros-Valdez

et al. 2023

Andrologia

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“…Therefore, α-tocopherol can be used to ameliorate ROS production in neurodegenerative disease through vitamin E supplementation. Liu et al [ 75 ] studied the effect of vitamin E on brain damage caused due to environmental pollutants mainly particulate matter (PM), gases, organic compounds, and metals. Amongst these, the most commonly encountered pollutant in indoor and outdoor air is PM 2.5 and formaldehyde (FA) which resulted in cognitive deficits, pathological brain alterations, β-Amyloid accumulation, glia activation, and oxidative stress.…”

Section: Antioxidants In Cns and Pnsmentioning

confidence: 99%

Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches

2021

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Antioxidants are a class of molecules with an innate affinity to neutralize reactive oxygen species (ROS), which are known to cause oxidative stress. Oxidative stress has been associated with a wide range of diseases mediated by physiological damage to the cells. ROS play both beneficial and detrimental roles in human physiology depending on their overall concentration. ROS are an inevitable byproduct of the normal functioning of cells, which are produced as a result of the mitochondrial respiration process. Since the establishment of the detrimental effect of oxidative stress in neurological disorders and neurotrauma, there has been growing interest in exploring antioxidants to rescue remaining or surviving cells and reverse the neurological damage. In this review, we present the survey of different antioxidants studied in neurological applications including neurotrauma. We also delve into bioengineering approaches developed to deliver antioxidants to improve their cellular uptake in neurological applications.

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“…However, they are generally expensive and complicated often requiring a long cycle of sampling and analysis by professionals. Even so, measurements usually reveal only time-averaged mean values, which do not necessarily reflect formaldehyde concentrations in real time [12].…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic metal organic framework for enhancing performance of acoustic wave formaldehyde sensor based on polyethyleneimine and bacterial cellulose nanofilms

Wang

Shang

Guo

et al. 2021

J Mater Sci: Mater Electron

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A surface acoustic wave (SAW) formaldehyde gas sensor was fabricated on a 42°75' ST-cut quartz substrate, with a composite sensing layer of zeolitic imidazolate framework (ZIF)-8 on polyethyleneimine (PEI)/ bacterial cellulose (BC) nanofilms.The addition of snowflake-like ZIF-8 structure on the PEI/BC sensitive film significantly improves the hydrophobicity of the SAW sensor and increases its sensitivity to formaldehyde gas. It also significantly increases surface roughness of the sensitive film. The hydrophobic nature of ZIF-8 prevents water molecules from entering into the internal pores of the BC film, thereby avoiding a significant mass loading caused by humidity when the sensor is used to detect low-concentration formaldehyde gas. The Zn 2+ sites at the surface of ZIF-8 improves the sensor's response to formaldehyde gas through enhanced physical adsorptions of gas molecules. Experimental results show that the ZIF-8@PEI/BC SAW sensor has a response (e.g., frequency shift) of 40.3 kHz to 10 ppm formaldehyde gas at 25℃ and 30% relative humidity (RH). When the relative humidity is increased from 30% to 93%, the response of the sensor only varies ~5%, and the change in response is negligible at medium humidity levels (~50 to 60% RH).

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Vitamin E reduces the extent of mouse brain damage induced by combined exposure to formaldehyde and PM2.5

Cited by 18 publications

References 13 publications

Protective Effect of Hedeoma drummondii against Formaldehyde-Induced Testicular Toxicity and Genotoxicity in Wistar Rats

Protective Effect of Hedeoma drummondii against Formaldehyde-Induced Testicular Toxicity and Genotoxicity in Wistar Rats

Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches

Hydrophobic metal organic framework for enhancing performance of acoustic wave formaldehyde sensor based on polyethyleneimine and bacterial cellulose nanofilms

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