Vitamin e status during dietary fish oil supplementation in rheumatoid arthritis

Abstract

The primary objective of this study was to determine whether it is the fish oil itself or the α‐tocopherol that is added to the fish oil preparations (to prevent peroxidation) that is responsible for the beneficial effects of dietary supplementation with fish oil in patients with rheumatoid arthritis (RA). One group of RA patients took fish oil supplements and another group took α‐tocopherol‐enriched coconut oil supplements (placebo controls), both for 3 months. Clinical and laboratory indices of RA activity in relation to cellular and plasma vitamin E levels were assessed at the beginning and the end of the trial. The results of the study provide evidence that the beneficial effects of fish oil supplementation cannot be ascribed to the antioxidizing properties of the α‐tocopherol per se.

A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain

“…(Hozo et al, 2005). Estimation was performed for three studies (Cleland et a1., 1988;Tulleken et al, 1990;Nielsen et al, 1992).…”

Long‐term effect of omega‐3 fatty acid supplementation in active rheumatoid arthritis

“…Beneficial effects of dietary supplementation with 0 3 have been demonstrated in some (4-7), but not all (8), animal models of inflammatory disease and in (mainly short-term) clinical studies in patients with rheumatoid arthritis (RA) (9)(10)(11)(12)(13)(14)(15)(16)(17). Long-term data in humans are presently scarce (18).…”

Role of Fatty Acids in the Resolution of Autoimmune and Inflammatory Diseases

“…Several authors reported that fish oils reduces the production of inflammatory mediators like LTB 4 by neutrophils and monocytes (Kremer et al, 1985;Kremer et al, 1987;Cleland et al, 1988;Tulleken et al, 1990;van der Tempel et al, 1990) and IL-1 by monocytes (Kremer et al, 1990). There is also evidence of reduction in the plasma concentrations of IL-1 (Espersen et al, 1992)and Creactive protein (Kremer et al, 1985), and normalized neutrophil function (Sperling et al, 1987).…”