Vitamin E status in Sudanese children with protein-energy malnutrition

Ahmed, Hassan; Laryea, Maurice D.; El-Karib, Abbas O; El-Amin, Elisa O.; Biggemann, B.; Leichsenring, Michael; Mayatepek, Ertan; Bremer, H. J.

doi:10.1007/bf02019534

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…Mean whole blood GPX activity was signi®cantly depressed in parallel with plasma Se in PEM children compared with control subjects. These results are in agreement with others (Golden & Ramdath 1987;Ahmed et al, 1990;Subotzky et al, 1992;Sive et al, 1993). During GPX de®ciency, hydrogen peroxide that escapes dissipation may metabolize by catalase enzyme.…”

Section: Discussionsupporting

confidence: 93%

Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt

Ashour

El-Gadban

et al. 1999

Eur J Clin Nutr

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Objectives: Free radicals are implicated in many diseases. The rise in free radicals associated with antioxidant de®ciency results in tissue damage. The pathogenesis of oedema and anaemia commonly found in children with protein-energy malnutrition (PEM) has been suggested to be caused by an imbalance between the production of toxic radicals and their safe disposal. The aim of this study was to evaluate antioxidant status in children with PEM. Design: A total of 68 children (age range: 3 months to 3 years) living in Cairo, Egypt were recruited. Forty-six of these subjects had different degrees of PEM; they were admitted at the Abo-Elrish Hospital, Cairo. Of these, 26 children had kwashiorkor (KWO) and twenty had marasmus (MAR). Twenty-two age and sex matched healthy well-nourished children were recruited from the local community, and used as controls. Methods: The antioxidant status of the study population was determined by measuring copper-zinc superoxide dismutase (Cu ± Zn, SOD) in red blood cells, glutathione peroxidase (GPX) in whole blood, and ceruloplasmin in plasma. In addition, the plasma levels of trace-elements involving antioxidant activities, such as copper (Cu), zinc (Zn), and selenium (Se) were determined, along with a select group of vitamins. The latter included vitamin A (retinol), vitamin E (a-tocopherol) and vitamin C (ascorbic acid). Results: The mean whole blood GPX activity along with plasma levels of vitamins A, E and C as well as ceruloplasmin, Cu and Se were all lower in children with either KWO or MAR than their corresponding control subjects. The erythrocyte SOD activity, on the other hand, was increased while the plasma Zn concentrations were either increased or not changed in the malnourished children. It was of interest that while haemoglobin concentrations were decreased, the plasma free iron (Fe) levels were signi®cantly increased in children with KWO. Conclusions: The signi®cant increase in red cell SOD activity associated with the decrease in plasma ceruloplasmin, antioxidant vitamins and the whole blood GPX activity in PEM children suggest that these children are potentially susceptible to high oxidative stress. An elevated plasma Fe concentrations, especially with KWO may augment the harmful effect of free radicals with a clinical consequence of oedema. Sponsorship: This study was ®nancially supported by The

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Section: Discussionsupporting

confidence: 93%

Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt

Ashour

El-Gadban

et al. 1999

Eur J Clin Nutr

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“…The serum vitamin E status was found to be extremely lower in patients. The reduced concentration of vitamin E may be due to enhanced generation of free radicals, that causes inflammation, leads to vascular leakage, which thereby results in oedema in Kwashiorkor [10,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Along with proteins, energy, and trace elements, vitamin E deficiency is more common and it adds to mortality and morbidity of the underlying disease. The deficiency of vitamin E has been suggested to be a causative factor in the anaemia of Kwashiorkor [14,15]. It is well known fact that concentrations of plasma vitamin E of above 500 μgm/dl is indicator of adequate vitamin E nutrition and depleted levels are always associated with fragility of erythrocytes [14].…”

Section: Introductionmentioning

confidence: 99%

A Study of Oxidative Stress Biomarkers and Effect of Oral Antioxidant Supplementation in Severe Acute Malnutrition

Ghone

Suryakar²,

Kulhalli³

et al. 2013

JCDR

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“…La diminution des défenses antioxydantes non enzymatiques: rétinol [50], a-tocophérol [16,21,25,51,52], caroténoïdes [53][54][55], zinc [20,25] et sélénium [19,20,21,24,26] chez les enfants malnutris confirme les résultats de précédentes études. Les micronutriments les plus sensibles sont les caroténoïdes, en parti culier la P-cryptoxanthine et les xanthophylles.…”

Section: Discussionunclassified

Evaluation du stress oxydant et des defenses antioxydantes chez l’enfant malnutri marocain

Houssaini¹,

Arnaud²,

Richard³

et al. 1997

Ann Nutr Metab

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In Morocco, malnutrition is a public health problem. Indeed, 25% of 6- to 60-month-old children suffer from malnutrition. Imbalance between antioxidant protection and prooxidant stress has been reported to accurately predict the survival of malnourished children. Therefore, we determined blood antioxidant vitamins (retinol, α-tocopherol and carotenoids), trace elements (serum zinc, copper and selenium) and enzymes (erythrocyte Se glutathione peroxydase and Cu-Zn superoxide dismutase) as well as blood oxidative stress index [ferritine, thiobarbituric-acid reactants (TBARS)] in 21 children suffering from severe malnutrition, 15 children suffering from mild malnutrition and in 20 healthy control children. Selenium, retinol, α-tocopherol and carotenoids were significantly decreased in malnourished children. These decreases were related to the severity of malnutrition. Moreover, the percentage of vitamin and trace element concentrations under deficient cutoff were high in malnourished children. On the contrary, TBARS, ferritin and prognostic inflammatory and nutritional index (PINI) were significantly increased in malnourished children. Except for TBARS, these increases were related to the severity of malnutrition. On the other hand, blood retinol, α-tocopherol, β-carotene and selenium were negatively related to α₁-acid glycoprotein. Blood β-cryptoxanthin, lycopene, carotenes and copper were positively related to weight. Finally, blood lutein/zeaxanthin and copper were positively related to height. These results confirm the imbalance between antioxidant protective factors and oxidative stress index in malnourished children. Moreover, the decrease in antioxidant protective factors is related to inflammation or stature. These results suggest that antioxidant micronutrient supplementation of the refeeding diet could be required in the nutritional rehabilitation of malnourished children.

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Vitamin E status in Sudanese children with protein-energy malnutrition

Cited by 10 publications

References 13 publications

Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt

Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt

A Study of Oxidative Stress Biomarkers and Effect of Oral Antioxidant Supplementation in Severe Acute Malnutrition

Evaluation du stress oxydant et des defenses antioxydantes chez l’enfant malnutri marocain

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Vitamin E status in Sudanese children with protein-energy malnutrition

Cited by 10 publications

References 13 publications

Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt

Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt

A Study of Oxidative Stress Biomarkers and Effect of Oral Antioxidant Supplementation in Severe Acute Malnutrition

Evaluation du stress oxydant et des defenses antioxydantes chez l&rsquo;enfant malnutri marocain

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Evaluation du stress oxydant et des defenses antioxydantes chez l’enfant malnutri marocain