Vitamin E supplementation modulates gingival crevicular fluid lipid peroxidation and antioxidant levels in patients with orthodontic tooth movement

Esenlik, Elçin; Nazıroğlu, Mustafa; Açıkalın, Cahide

doi:10.1002/cbf.1833

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…After day 3, movement for group 1 reduced, while for group 2, this continued to increase until day 7. force stimulate the production of reactive oxygen species and free radicals, which contribute to cellular and tissue damage, especially damaging lipid peroxidation chains 22 . Vitamin E is a strong biological antioxidant that has several functions: scavenges free radicals, which inhibit lipid peroxidation and inflammation; protects ischemic tissue and hypoxia; provides immunostimulation 11,23 . Norazlina et al observed the effect of vitamin E supplementation on bone metabolism in mice treated with nicotine.…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats: a prelimary study

2020

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Background: Tooth movement induced by the application of orthodontic force was initiated by inflammatory process. Studies have shown that vitamin E has an anti-inflammatory and antioxidant properties which perhaps could inhibit the tooth to move. This study aimed to evaluate the effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats. Methods: Wistar rats (n=56) were divided into two groups. Group 1 served as the control groups, while group 2 was given vitamin E for 14 days before application of orthodontic force. Each group was divided into four subgroups (n=7), corresponding to the number of days orthodontic force lasted, i.e. 0, 1, 3, 7 days. At each of these four time points, distance measurements and quantity of osteoblasts-osteoclasts were measured in each rat. Results: Tooth movement distance was increased for group 2 than group 1 for all time intervals, but this difference was only statistically different on day 3 (p=0.001). For both groups, tooth movement was significantly different between each time interval in each group (p=0.041). The mean number of osteoblast cells was increased for group 2 compared to group 1 for all time intervals (p<0.05), but was not significant different between time intervals (p=0.897). The number of osteoclasts was not significantly different between groups, but it was statistically different between time intervals (p=0.004). Conclusion: The outcome of this study demonstrated that group 2 resulted a better tooth movement compared to group 1 and significantly found on day 3, based on the distance measurement. The osteoclast cell numbers were the same within both control groups, whilst the number of osteoblast cells in group 2 was significantly higher than those in group 1.

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Section: Resultsmentioning

confidence: 99%

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats: a prelimary study

2020

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“…Hypoxia and compression caused by orthodontic force stimulate the production of reactive oxygen species and free radicals, which contribute to cellular and tissue damage, especially damaging lipid peroxidation chains 22 . Vitamin E is a strong biological antioxidant that has several functions: scavenges free radicals, which inhibit lipid peroxidation and inflammation; protects ischemic tissue and hypoxia; provides immunostimulation 11,23 . Norazlina et al observed the effect of vitamin E supplementation on bone metabolism in mice treated with nicotine.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that vitamin E has anti-inflammatory properties, which helps suppress damaging effects of oxygen free radicals in cells during bone formation 10 . Previous studies carried out by Esenlik et al and Xu et al suggest that vitamin E supplementation may alter cytokine production; vitamin E supplement maintains normal bone remodelling in young animals and increases bone mass by decreasing the concentration of free radicals which suppress bone formation 11,12 .…”

Section: Introductionmentioning

confidence: 98%

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats: a prelimary study

2020

View full text Add to dashboard Cite

Background: Tooth movement induced by the application of orthodontic force was initiated by inflammatory process. Studies have shown that vitamin E has an anti-inflammatory and antioxidant properties which perhaps could inhibit the tooth to move. This study aimed to evaluate the effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats. Methods: Wistar rats (n=56) were divided into two groups. Group 1 served as the control groups, while group 2 was given vitamin E for 14 days before application of orthodontic force. Each group was divided into four subgroups (n=7), corresponding to the number of days orthodontic force lasted, i.e. 0, 1, 3, 7 days. At each of these four time points, distance measurements and quantity of osteoblasts-osteoclasts were measured in each rat. Results: Tooth movement distance was increased for group 2 than group 1 for all time intervals, but this difference was only statistically different on day 3 (p=0.001). For both groups, tooth movement was significantly different between each time interval in each group (p=0.041). The mean number of osteoblast cells was increased for group 2 compared to group 1 for all time intervals (p<0.05), but was not significant different between time intervals (p=0.897). The number of osteoclasts was not significantly different between groups, but it was statistically different between time intervals (p=0.004). Conclusion: The outcome of this study demonstrated that group 2 resulted a better tooth movement compared to group 1 on day 3, based on the distance measurement. The osteoclast cell numbers were the same within control groups, whilst the number of osteoblast cells in group 2 was significantly higher than those in group 1.

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“…Hypoxia and compression caused by orthodontic force stimulate the production of reactive oxygen species and free radicals, which contribute to cellular and tissue damage, especially damaging lipid peroxidation chains 18 . Vitamin E is a strong biological antioxidant that has several functions: scavenges free radicals, which inhibit lipid peroxidation and inflammation; protects ischemic tissue and hypoxia; provides immunostimulation 11,19 . Norazlina et al observed the effect of vitamin E supplementation on bone metabolism in mice treated with nicotine.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats

2020

View full text Add to dashboard Cite

Background: Tooth movement induced by the application of orthodontic force is facilitated by bone remodelling cells and chemical mediators. Vitamin E has anti-inflammatory properties, which helps in suppressing the damaging effects of oxygen free radicals in cells during bone formation. This study aimed to evaluate the effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats. Methods: Wistar rats (n=56) were divided into two groups. Group 1 served as the control groups, while group 2 was given vitamin E for 14 days before application of orthodontic force. Each group was divided into four subgroups (n=7), corresponding to the number of days orthodontic force lasted, i.e. 0, 1, 3, 7 days. At each of these four time points, distance measurements and quantity of osteoblasts-osteoclasts were measured in each rat. Results: Tooth movement distance was increased for group 2 than group 1 for all time intervals, but this difference was only statistically different on day 3 (p=0.001). For both groups, tooth movement was significantly different between each time interval in each group (p=0.041). The mean number of osteoblast cells was increased for group 2 compared to group 1 for all time intervals (p<0.05), but was not significant different between time intervals (p=0.897). The number of osteoclasts was not significantly different between groups, but it was statistically different between time intervals (p=0.004). Conclusion: Present outcomes demonstrate that vitamin E contributes to faster tooth movement compared to control group. It also stimulates more bone formation without reducing the bone resorption.

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Vitamin E supplementation modulates gingival crevicular fluid lipid peroxidation and antioxidant levels in patients with orthodontic tooth movement

Cited by 9 publications

References 27 publications

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats: a prelimary study

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats: a prelimary study

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats: a prelimary study

Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats

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