Vitamin E

Traber, Maret G.

doi:10.1002/9781119946045.ch14

Cited by 34 publications

(54 citation statements)

References 98 publications

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“…Quando a concentração de alfa-tocoferol foi comparada com a de outros estudos, apresentaram médias (1.938,1±766,6 μg/dL) superiores às encontradas em mulheres americanas (1.128,4 μg/dL) 10 e de Cuba (1.029,4 μg/dL) 11 . Uma explicação para os níveis mais altos de alfa-tocoferol sérico encontrado em nosso estudo pode ser devido ao fato de que a dieta americana contém uma maior proporção de gama tocoferol em relação ao alfa-tocoferol 12 .…”

Section: Discussionunclassified

Vitamin E in human serum and colostrum under fasting and postprandial conditions

et al. 2010

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Objective: To evaluate alpha-tocopherol concentrations in maternal serum and colostrum under fasting and postprandial conditions. Methods:Thirty healthy childbearing women were recruited in a public maternity hospital, and samples of blood, fasting colostrum, and postprandial colostrum were collected from them up to 12 hours after delivery. Results:The serum alpha-tocopherol concentration was 1 , 9 3 9 . 8 ± 7 6 6 . 0 μ g / d L . A l p h a -t o c o p h e r o l l e ve l s i n f a s t i n g colostrum (1,603.4±911.0 μg/dL) and in postprandial colostrum (1,515.0±890.9 μg/dL) did not demonstrate a statistically significant difference (p > 0.05). There was correlation between alpha-tocopherol levels in fasting and postprandial colostrum (p < 0.05), but not between serum and colostrum. Conclusions:The lack of correlation between alpha-tocopherol levels in plasma and in colostrum, and the correlation between alphatocopherol concentrations in fasting and postprandial colostrum support the existence of a mechanism that controls the transfer of this nutrient, regardless of dietary intake.J Pediatr (Rio J). 2010;86(4):345-348: Alpha-tocopherol, serum, colostrum. ResumoObjetivo: Avaliar a concentração de alfa-tocoferol no soro e colostro maternos, seja em condições de jejum ou pós-prandial. Métodos:Trinta parturientes saudáveis atendidas em uma maternidade pública foram recrutadas para o estudo, e amostras de sangue, colostro em jejum e colostro pós-prandial foram coletadas até 12 horas pós-parto.Resultados: A concentração sérica de alfa-tocoferol foi de 1.939,8±766,0 μg/dL. O alfa-tocoferol no colostro em jejum, 1.603,4±911,0 μg/dL, e após a refeição, 1.515,0±890,9 μg/dL, não apresentaram diferença significativa (p > 0,05). Houve correlação entre o alfa-tocoferol do colostro na condição de jejum e no pós-prandial (p < 0,05), mas não entre o soro e o colostro.Conclusão: A falta de correlação entre o alfa-tocoferol no plasma e no colostro e a correlação entre o alfa-tocoferol no colostro em jejum e no pós-prandial reforçam a hipótese de um mecanismo de controle na passagem desse micronutriente, independente do aporte dietético. IntroduçãoA vitamina E é um termo genérico utilizado para designar oito compostos naturais, sendo o alfa-tocoferol o que possui maior atividade biológica 1 . Estudos epidemiológicos têm indicado um provável envolvimento da deficiência de vitamina E na patogênese da aterosclerose, diabetes e alguns tipos de câncer, bem como na modulação da inflamação e resposta imune 2 .Durante a gestação, a transferência placentária do alfa-tocoferol é limitada, e o feto apresenta baixa concentração circulante dessa vitamina. Após o parto, o leite é de extrema importância para o abastecimento do alfatocoferol ao recém-nascido, pois é essencial na defesa contra a toxicidade do oxigênio e auxilia a estimular o desenvolvimento de seu sistema imunológico 1 .1. Doutor, Bioquímica. Professor adjunto IV, Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN. ...

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Section: Discussionunclassified

Vitamin E in human serum and colostrum under fasting and postprandial conditions

et al. 2010

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“…Although RTE breakfast cereals may be fortified with vitamin E, it is not added back as a standard enrichment measure. Deliberations concerning addition of this vitamin to the enrichment mixture might be warranted but would need to consider the biological activity of various tocopherol isomers that some processing methods, such as extrusion and baking, can decrease (142,143).…”

Section: Vitamin Ementioning

confidence: 99%

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Cereal Foods World

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“…In the liver, a-tocopherol selectively binds to a-tocopherol transfer protein (a-TTP) and is incorporated into very low-density lipoproteins (VLDL). a-TTP is a hepatic cytosolic protein, which facilitates the transport of a-tocopherol to the plasma membrane for the secretion of a-tocopherol into VLDL (1). a-TTP has a critical role in maintaining circulatory a-tocopherol levels.…”

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confidence: 99%

“…Of all these vitamin E subtypes, a-tocopherol is the most well-known for its antioxidant activity (1). Lipid-soluble vitamin E has a critical role as an antioxidant protecting the lipids of the plasma membranes and lipoproteins from peroxidation.…”

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confidence: 99%

“…a-TTP has a critical role in maintaining circulatory a-tocopherol levels. a-TTP gene disrupted mice reveal markedly reduced plasma a-tocopherol levels; moreover, the mutation of the human a-TTP gene is responsible for ataxia with vitamin E deficiency (1,2). The ATPbinding cassette transporter-1 (ABCA-1), which transports cholesterol and phospholipids, facilitates the secretion of a-tocopherol in the plasma membrane.…”

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α-Tocopherol Status and Altered Expression of α-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models

Takitani

Inoue

Koh

et al. 2014

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Vitamin E is a fat-soluble antioxidant that comprises 4 tocopherols (a-, b-, g-, and d-) and 4 tocotrienols (a-, b-, g-, and d-). Of all these vitamin E subtypes, a-tocopherol is the most well-known for its antioxidant activity (1). Lipid-soluble vitamin E has a critical role as an antioxidant protecting the lipids of the plasma membranes and lipoproteins from peroxidation. Dietary vitamin E, including tocopherols and tocotrienols, which are components of bile salt micelles, is absorbed in the intestine. Vitamin E, along with lipids, is incorporated into nascent chylomicrons within the enterocyte, and these chylomicrons are then secreted into the lymphatics and blood vessels (2). After transporting dietary lipids to other locations in the body, chylomicrons are returned to and taken up by the liver. In the liver, a-tocopherol selectively binds to a-tocopherol transfer protein (a-TTP) and is incorporated into very low-density lipoproteins (VLDL). a-TTP is a hepatic cytosolic protein, which facilitates the transport of a-tocopherol to the plasma membrane for the secretion of a-tocopherol into VLDL (1). a-TTP has a critical role in maintaining circulatory a-tocopherol levels. a-TTP gene disrupted mice reveal markedly reduced plasma a-tocopherol levels; moreover, the mutation of the human a-TTP gene is responsible for ataxia with vitamin E deficiency (1, 2). The ATPbinding cassette transporter-1 (ABCA-1), which transports cholesterol and phospholipids, facilitates the secretion of a-tocopherol in the plasma membrane. VLDL, including a-tocopherol, in circulation is lipolysed into low-density lipoprotein (LDL) by lipoprotein lipase, and this LDL is taken up into the peripheral tissues via the action of the LDL receptor. The mechanism of a-tocopherol metabolism has been recently determined (2). The catabolism of tocopherols and tocotrienols is mediated by cytochrome P450 4F2 (CYP4F2), and the resulting metabolite, carboxyethyl hydroxychroman (CEHC), is excreted in urine as glucuronic conjugates.Diabetes is a metabolic disorder pertaining to glucose uptake due to a lack of insulin production by pancreatic b-cells (type 1 diabetes), or it manifests as peripheral insulin resistance, including adipose tissue and muscles (type 2 diabetes). The production of reactive oxygen species (ROS) is the major pathogenesis of diabetes and its complications. Hyperglycemia leads to an increased release of ROS in peripheral tissues (3). In experimental studies, vitamin E supplementation improved the Summary Vitamin E plays a critical role as an antioxidant in several pathological conditions, including diabetes, cancer, cardiovascular diseases, and neurodegenerative disorders. Diabetes is a metabolic disorder of glucose due to the lack of adequate insulin production (type 1) or peripheral insulin resistance (type 2). Oxidative stress plays a major role in the pathogenesis of diabetes and its complications. The purpose of the present study was to determine a-tocopherol status and the expression of a-tocopherol-related proteins, including ...

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Vitamin E

Cited by 34 publications

References 98 publications

Vitamin E in human serum and colostrum under fasting and postprandial conditions

Vitamin E in human serum and colostrum under fasting and postprandial conditions

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α-Tocopherol Status and Altered Expression of α-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models

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Vitamin E

Cited by 34 publications

References 98 publications

Vitamin E in human serum and colostrum under fasting and postprandial conditions

Vitamin E in human serum and colostrum under fasting and postprandial conditions

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&alpha;-Tocopherol Status and Altered Expression of &alpha;-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models

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α-Tocopherol Status and Altered Expression of α-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models