Vitamin E (α-tocopherol) consumption influences gut microbiota composition

Choi, Yukyung; Lee, Soomin; Kim, Sejeong; Lee, Jeeyeon; Ha, Jimyeong; Oh, Hyemin; Lee, Yewon; Kim, Yujin; Yoon, Yohan

doi:10.1080/09637486.2019.1639637

Cited by 72 publications

(46 citation statements)

References 18 publications

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“…Though some of the studies did control for extreme variances in diet however it cannot be discounted that variances in diet between AD patients and controls might have affected levels of the tocopherls [58]. A further consideration is that diet including intake of tocopherols [59] has been shown to influence gut microbiota, and gut microbiota has in turn been linked with AD [60].…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

Ashley

Bradburn

Murgatroyd

2019

Nutritional Neuroscience

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Findings from observational studies and clinical trials on the associations between vitamin E and dementia remain controversial. Here we conducted a meta-analysis to determine the difference in blood tocopherols levels between patients with Alzheimer's disease (AD) or age-related poor cognitive function and healthy controls. Standardised mean difference (SMD) and 95% confidence intervals (CIs) were calculated and entered into a random effects model. Study quality, heterogeneity and publication bias were also investigated. Thirty-one articles were included in the meta-analysis, which included analyses for α-, β-, γ-and δ-tocopherols. These results indicated that individuals with AD or agerelated cognitive deficits and mild cognitive impairment (MCI) had lower circulatory concentrations of α-tocophenol compared with healthy controls (AD: SMD = −0.97, 95% confidence interval [CI] = −1.27 to −0.68, Z = 6.45, P < 0.00001; age-related cognitive deficits and MCI: SMD = −0.72, 95% CI = −1.12 to −0.32, Z = −3., P < 0.0005). Levels of β-, γ-and δ-tocophenols did not significantly differ between groups of AD and age-related cognitive deficits compared to controls. These results suggest that lower α-tocopherol levels have a strong association with AD and MCI supporting evidence for the role of diet and vitamin E in AD risk and agerelated cognitive decline.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

Ashley

Bradburn

Murgatroyd

2019

Nutritional Neuroscience

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“…The influence of vitamin E on the gut microbial community is poorly studied. The study conducted by Choi et al [186] indicated that low-level consumption of vitamin E increased spleen and body weight and negatively changed the Firmicutes to Bacteroidetes ratio. However, the effect of vitamin E supplementation on changes in the GM in NAFLD/NASH patients is still lacking, and this relationship should be explored in further intervention studies.…”

Section: Vitamin E and Vitamin D And Nafldmentioning

confidence: 99%

Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date

Moszak

Szulińska

Walczak-Gałęzewska

et al. 2021

IJERPH

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Non-alcoholic fatty liver disease (NAFLD) is a significant clinical and epidemiological problem that affects around 25% of the adult global population. A large body of clinical evidence highlights that NAFLD is associated with increased liver-related morbidity and mortality and an increased risk of cardiovascular disease, extrahepatic cancers, type 2 diabetes, and chronic kidney disease. Recently, a series of studies revealed the pivotal role of gut microbiota (GM) dysbiosis in NAFLD’s pathogenesis. The GM plays an essential role in different metabolic pathways, including the fermentation of diet polysaccharides, energy harvest, choline regulation, and bile acid metabolism. One of the most critical factors in GM stabilization is the diet; therefore, nutritional therapyappearsto be a promising tool in NAFLD therapy. This paper aims to review the current knowledge regardingthe nutritional approach and its implications with GM and NAFLD treatment. We discuss the positive impact of probiotics, prebiotics, and symbiotics in a reverse dysbiosis state in NAFLD and show the potential beneficial effects of bioactive substances from the diet. The full description of the mechanism of action and comprehensive examination of the impact of nutritional interventions on GM modulation may, in the future, be a simple but essential tool supporting NAFLD therapy.

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“…Chronic vitamin E deficiency could increase the risk of damage in response to oxidative stress. A recent study observed that a moderate intake of vitamin E changed the composition of gut microbiota and altered intestinal microbiota involved in the pathogenesis of ALD[ 78 ]. In a clinical trial of patients with nonalcoholic steatohepatitis and advanced fibrosis, Vilar-Gomez et al[ 79 ] found that vitamin E supplementation improved patients’ clinical outcomes including reducing the risk of death or liver transplant and the probability of hepatic decompensation[ 79 ].…”

Section: Vitamin Metabolism In Aldmentioning

confidence: 99%

“…Most of the studies discussed in this review included a limited number of subjects. Although small studies have multiple practical advantages, such as being timesaving in the enrollment of subjects, and high flexibility in data analyses[ 90 ], results from these small samples are usually attached to low statistical power[ 78 ], and are more likely to generate false-positive results. In this regard, these biomedical findings may only demonstrate statistically significant effects but have no clinical utility.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease

Meng

2020

WJG

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Alcoholic liver disease (ALD) remains an important health problem worldwide. Perturbation of micronutrients has been broadly reported to be a common characteristic in patients with ALD, given the fact that micronutrients often act as composition or coenzymes of many biochemical enzymes responsible for the inflammatory response, oxidative stress, and cell proliferation. Mapping the metabolic pattern and the function of these micronutrients is a prerequisite before targeted intervention can be delivered in clinical practice. Recent years have registered a significant improvement in our understanding of the role of micronutrients on the pathogenesis and progression of ALD. However, how and to what extent these micronutrients are involved in the pathophysiology of ALD remains largely unknown. In the current study, we provide a review of recent studies that investigated the imbalance of micronutrients in patients with ALD with a focus on zinc, iron, copper, magnesium, selenium, vitamin D and vitamin E, and determine how disturbances in micronutrients relates to the pathophysiology of ALD. Overall, zinc, selenium, vitamin D, and vitamin E uniformly exhibited a deficiency, and iron demonstrated an elevated trend. While for copper, both an elevation and deficiency were observed from existing literature. More importantly, we also highlight several challenges in terms of low sample size, study design discrepancies, sample heterogeneity across studies, and the use of machine learning approaches.

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Vitamin E (α-tocopherol) consumption influences gut microbiota composition

Cited by 72 publications

References 18 publications

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date

Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease

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