Vitamin E (α-tocopherol) enhances the PDT action of hematoporphyrin derivatives on cervical cancer cells

Al-Sherbini, El-Sayed A.M.; Noury, Amr H.El; Rouby, Mahmoud N. El; Ibrahim, Tarek

doi:10.1016/j.mla.2008.11.004

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…In the present study, α-tocopherol ( 6 ), which is a dietary antioxidant, displayed pronounced cytotoxicity against CasKi (IC 50 6 µg/mL) and A549 (IC 50 6 µg/mL). The result obtained here is consistent with other reports [37,38,39,40,47,48,49,50] on cytotoxic activities in other cell lines. Lesser number of investigations described an opposite effect [44,45,46].…”

Section: Resultssupporting

confidence: 93%

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

et al. 2009

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Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC50 value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.

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Section: Resultssupporting

confidence: 93%

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

et al. 2009

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“…It is apparent that high numbers of cancer patients are using antioxidants with or without the knowledge of their oncologist. The use of antioxidants during cancer therapy is currently a debated topic because of some contradictory findings (Akbas et al 2006;Al-Sherbini et al 2009;Sun et al 2009). Some data indicate that antioxidants can protect healthy cells and tissues from the damage of free radical without affecting treatment efficacy (Akbas et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Frank et al discovers that increasing intracellular concentrations of vitamin C contribute to the resistance of cultured cancer cells to prooxidant treatment modalities as ALA-PDT (Frank et al 2006). Al-Sherbini et al (2009) found that high concentrations of vitamin E enhance the PDT action against HeLa cervical cancer cell line. Rubio and colleagues (Rubio et al 2014) demonstrates that in PDT-treated cells a p38MAPK-regulated pathway coordinates the p62/NBR1mediated clearance of cytosolic aggregates and mitigates PDT-induced proteotoxicity.…”

Section: Discussionmentioning

confidence: 99%

The effect of ellagic acid on photodynamic therapy in leukemia cells

Lü¹,

Zhang²,

Wang³

et al. 2018

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Ellagic acid (EA) is a naturally phenolic acid presented in different foods. It has a variety of biological activities including antioxidant, anti-inflammatory, anti-microbiological and anti-cancer properties. On account of its antioxidant activity, EA might protect cancer cells from free radical damage in photodynamic therapy (PDT) during which reactive oxygen species (ROS) production was stimulated leading to irreversible tumor cell injury. In this study, the influence of EA on K562 cells in 5-aminolevulinic acid (ALA)-based PDT is demonstrated. Cell apoptosis was assayed by flow cytometry. Oxidative damage induced by PDT was investigated by measurement of malondialdehyde (MDA). Comet assay was used to evaluate the potential genotoxic effect induced by PDT on the cells. The results showed that EA supplementation alone did not affect the lipid peroxidation, DNA damage and apoptosis in K562 cells. It increases the lipid peroxidation, DNA damage, apoptosis and decreases the survival rate in K562 cells induced by ALA-PDT. The singlet oxygen quencher sodium azide suppresses apoptosis, lipid peroxidation and DNA damage induced by EA in PDT. In conclusion, EA consumption during PDT did not decrease the effectiveness of cancer therapy on malignant cells. The effect of antioxidants on PDT maybe was determined by its sensitization ability to singlet oxygen.

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“…found that high concentrations of vitamin E enhance the PDT action against HeLa cervical cancer cell line (Al-Sherbini et al 2009); pre-treatment with tyrosine kinase inhibitor genistein may significantly improve the effectiveness of PDT with hypericin in MCF-7 and MDA-MB-231 breast cancer cells (Ferenc 2010); in PDT-treated cells a p38MAPK-regulated pathway coordinates the p62/NBR1-mediated clearance of cytosolic aggregates and mitigates PDT-induced proteotoxicity (Rubio et al 2014). Our previous study (Zhang et al 2012) found the soybean isoflavones genistein and daidzein did not decrease the effectiveness of cancer therapy on malignant cells.…”

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confidence: 98%

Research on the effect of formononetin on photodynamic therapy in K562 cells

Lü¹,

Zhang²,

Wang³

et al. 2017

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At the present time, many cancer patients combine some forms of complementary and alternative medicine therapies with their conventional therapies. The most common choice of these therapies is the use of antioxidants. Formononetin is presented in different foods. It has a variety of biological activities including antioxidant and anti-cancer properties. On account of its antioxidant activity, formononetin might protect cancer cells from free radical damage in photodynamic therapy (PDT) during which reactive oxygen species (ROS) production was stimulated leading to irreversible tumor cell injury. In this study, the influence of formononetin on K562 cells in PDT was demonstrated. The results showed that formononetin supplementation alone did not affect the lipid peroxidation, DNA damage and apoptosis in K562 cells. It increases the lipid peroxidation, DNA damage and apoptosis in K562 cells induced by PDT. The singlet oxygen quencher sodium azide suppresses the apoptosis induced by PDT with formononetin. In conclusion, formononetin consumption during PDT increases the effectiveness of cancer therapy on malignant cells. The effect of antioxidants on PDT maybe was determined by its sensitization ability to singlet oxygen.

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Vitamin E (α-tocopherol) enhances the PDT action of hematoporphyrin derivatives on cervical cancer cells

Cited by 10 publications

References 23 publications

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

The effect of ellagic acid on photodynamic therapy in leukemia cells

Research on the effect of formononetin on photodynamic therapy in K562 cells

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