Vitamin K in infancy

Subclinical liver dysfunction in one-month-old infants with a low activity of vitamin K dependent coagulant factors assessed by normotest.

“…Late HD can be idiopathic or may occur as a secondary manifestation of an underlying disorder. Although the cause of idiopathic late HD remains unknown, breast feeding has been implicated as an important factor in the pathogenesis (Nakayama 1982;Lane and Hathaway 1985;Hanawa et al 1988;von Kries et al 1988). A recent study, however, comparing breast-fed and bottle-fed infants at 30 days of age found no differences in vitamin K dependent reported that the idiopathic form of late neonatal vitamin K deficiency was associated with subclinical liver dysfunction including abnormally high levels of serum direct bilirubin, ALP and total bile acids in Japanese breast-fed infants (Matsuda et al 1989).…”

“…vitamin K deficiency ; normotest ; subclinical liver dysfunction Vitamin K deficiency hemorrhagic diseases (HD) are classified into three groups ; early HD of the newborn, classic HD of the newborn and late HD (Lane and Hathaway 1985;von Kries et al 1988). The late HD of infancy generally occurs in breast-fed infants, between the age of 1 to 3 months (Lane and Hathaway 1985;von Kries et al 1988).…”

“…The late HD of infancy generally occurs in breast-fed infants, between the age of 1 to 3 months (Lane and Hathaway 1985;von Kries et al 1988). Recently a study group in Japan reported that the incidence of vitamin K deficiency HD in Japan was 1: 4,500 in unselected infants and 1:1,700 in breast-fed infants, resulting in 400 affected infants per year (Nakayama 1982 The purpose of this study was to determine whether or not subclinical liver dysfunction occurs in one-month-old infants with normotest values of less than 40% in a screening for vitamin K deficiency HD.…”

Vitamina K: metabolismo e nutrição

“…-Doença Hemorrágica do recém-nato: a doença hemorrágica dos recém-natos é uma síndrome bem reconhecida, relacionada à deficiência de vitamina K (Lane & Hathaway, 1985). Fatores como imaturidade hepática, luz intestinal estéril e baixo conteúdo de vitamina K no leite materno são contribuintes para a deficiência da vitamina nessa população (Andrew et al, 1987;Canfield & Hopkinson, 1989).…”

Current perspectives and practices of newborn vitamin K administration in low and middle income countries

“…1 The disease presents in one of the following three ways: early, classic, and late. 2 Early VKDB occurs within 24 hours of birth and is very rare and usually a consequence of drugs that have been given to the mother (such as anticonvulsants) that interfere with metabolism. Classic VKDB occurs 1-7 days after birth and is known to be caused by inadequate feeding and milk intake.…”