Vitamina D: ações extraósseas e uso racional

Abstract

Recent years have witnessed a substantial increase in the number of seric determinations of vitamin D, in a worldwide basis. At Hospital das Clínicas of Faculdade de Medicina of Universidade de São Paulo that increase reached 700% over the last four years. Nevertheless there are many controversies on the literature about the role of vitamin D in conditions unrelated to the musculoskeletal system. In this study the metabolism, sources and actions of vitamin D on the body are reviewed. Observational studies, clinical trials, systematic reviews and metanalysis which focused on the relationship between the vitamin and conditions such as cancer, cardiovascular disease, diabetes and falls were searched on the literature, analyzed and discussed. Results are presented as quiz and answer, tables and a figure. The role of vitamin D on the above-mentioned conditions is discussed, and the controversial issues stressed.

Association of vitamin D and vitamin B12 with cognitive impairment in elderly aged 80 years or older: a cross‐sectional study

“…Some studies have reported vitamin D deficiency to be a public health concern because of the growing number of people diagnosed with this deficiency and also because of the impacts of this deficiency on cancer, diabetes mellitus, depression, psychosis, cardiovascular disease, falls, muscle function, physical strength and hyperparathyroidism (23)(24)(25)(26)(27)(28) .…”

Colecalciferol: Uma Análise Crítica De Produtos Manipulados E Industrializados

“…Fontes endógenas de vitamina D permanecem duas vezes mais tempo no organismo que as exógenas. Entretanto, a vitamina D oriunda da exposição solar é influenciada por diversos fatores, como estação do ano, pigmentação da pele e uso de protetor solar, e a sua ingestão natural através da dieta, representa apenas uma pequena parte necessária para atender as necessidades humanas (5). Desta forma, na falta de uma exposição regular à luz do sol, apenas as fontes alimentares não são suficientes para manter níveis adequados e por isto a suplementação com medicamentos tem sido constantemente necessária (9).…”

Association of hematology profile with serum 25-hydroxy vitamin D and Bsml polimorphism in community-dwelling older adults

“…However, in the last years, an important body of evidence has associated this metabolite with many extraskeletal outcomes, such as diabetes, cancer, and metabolic syndrome 6 . More recently, observational studies reported a relationship between vitamin D level and hemoglobin in many populations, especially in older adults [7][8][9][10] .…”