Vitamins, Are They Safe?

Hamishehkar, Hadi; Ranjdoost, Farhad; Asgharian, Parina; Mahmoodpoor, Ata; Sanaie, Sarvin

doi:10.15171/apb.2016.061

Cited by 61 publications

(39 citation statements)

References 92 publications

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“…Finally, omics sciences if sex and gender-oriented, will also help other important auxiliary health-related disciplines, such as those involved in food-sciences and nutrition, where efforts to recognize personalized diets in relationship to health is the first step in preventive medicine [299]. One extraordinary field in which this could be applied is the multivitamin supplement (e.g., folic acid) during the pre-and peri-conception period, not universally considered safe for every mother in absence of a detailed genomic analysis [300][301][302]. Finally, if part of these advances will be accomplished, this will significantly improve the global health at any age and stage and for any sex and gender cutting down health care costs of the Public Health Systems.…”

Section: Sex/gender Disparity In the Omics Era: Sex-omics And Gender-mentioning

confidence: 99%

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

Gemmati

Varani

Bramanti

et al. 2019

IJMS

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Gender medicine is the first step of personalized medicine and patient-centred care, an essential development to achieve the standard goal of a holistic approach to patients and diseases. By addressing the interrelation and integration of biological markers (i.e., sex) with indicators of psychological/cultural behaviour (i.e., gender), gender medicine represents the crucial assumption for achieving the personalized health-care required in the third millennium. However, ‘sex’ and ‘gender’ are often misused as synonyms, leading to frequent misunderstandings in those who are not deeply involved in the field. Overall, we have to face the evidence that biological, genetic, epigenetic, psycho-social, cultural, and environmental factors mutually interact in defining sex/gender differences, and at the same time in establishing potential unwanted sex/gender disparities. Prioritizing the role of sex/gender in physiological and pathological processes is crucial in terms of efficient prevention, clinical signs’ identification, prognosis definition, and therapy optimization. In this regard, the omics-approach has become a powerful tool to identify sex/gender-specific disease markers, with potential benefits also in terms of socio-psychological wellbeing for each individual, and cost-effectiveness for National Healthcare systems. “Being a male or being a female” is indeed important from a health point of view and it is no longer possible to avoid “sex and gender lens” when approaching patients. Accordingly, personalized healthcare must be based on evidence from targeted research studies aimed at understanding how sex and gender influence health across the entire life span. The rapid development of genetic tools in the molecular medicine approaches and their impact in healthcare is an example of highly specialized applications that have moved from specialists to primary care providers (e.g., pharmacogenetic and pharmacogenomic applications in routine medical practice). Gender medicine needs to follow the same path and become an established medical approach. To face the genetic, molecular and pharmacological bases of the existing sex/gender gap by means of omics approaches will pave the way to the discovery and identification of novel drug-targets/therapeutic protocols, personalized laboratory tests and diagnostic procedures (sex/gender-omics). In this scenario, the aim of the present review is not to simply resume the state-of-the-art in the field, rather an opportunity to gain insights into gender medicine, spanning from molecular up to social and psychological stances. The description and critical discussion of some key selected multidisciplinary topics considered as paradigmatic of sex/gender differences and sex/gender inequalities will allow to draft and design strategies useful to fill the existing gap and move forward.

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Section: Sex/gender Disparity In the Omics Era: Sex-omics And Gender-mentioning

confidence: 99%

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

Gemmati

Varani

Bramanti

et al. 2019

IJMS

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“…Os efeitos colaterais e as possíveis propriedades nocivas e prejudiciais de vitaminas foram avaliadas por Hamishehkar et al (2016), analisando a sua utilização como produtos de saúde seguros ou suplementos dietéticos. Este estudo demonstrou que a ingestão de suplementos das vitaminas E, A, C, D e ácido fólico para a prevenção de doenças nem sempre é eficaz e pode até ser prejudicial para a saúde.…”

Section: Incidência De Cálculos Renaisunclassified

“…A maioria das pessoas acredita que se as vitaminas não são eficazes, pelo menos elas são seguras. No entanto, as consequências para a saúde do consumo de vitaminas a longo prazo são desconhecidas (HAMISHEHKAR et al, 2016). O termo "antioxidante" precisa ser utilizado com Jordana Tres Santos et al 142 cautela, tendo sido proposto por Olson (1996) a utilização do termo "moduladores fisiológicos", por ser mais abrangente e incluir os efeitos adversos eventualmente resultantes do uso abusivo dessas substâncias.…”

Section: Introductionunclassified

Os Efeitos Da Suplementação Com Vitamina C

Santos

Krützmann

Bierhals

et al. 2019

RCO

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Revista Conhecimento Online | Novo Hamburgo | a. 11 | v. 1 | jan./abr. 2019Jordana Tres Santos et al. RESUMOA vitamina C ou ácido ascórbico (AA) é um elemento essencial para o ser humano e, por não ser metabolizado pelo corpo, necessitamos da sua ingestão pela dieta e/ou suplementação. As funções do AA no corpo são inúmeras, tais como: cofator para enzimas, biossíntese de hormônios e ação antioxidante, entretanto, estudos relatam que o consumo de AA em doses elevadas pode oferecer riscos à saúde. Deste modo, buscou-se analisar os efeitos descritos da suplementação de AA. Realizamos uma revisão bibliográfica, dividida em duas perspectivas: uma histórica, com publicações de 1753 a 2012; e outra contemporânea, com estudos realizados entre 1990 e 2017. A pesquisa foi realizada no Science Direct, Scielo, PubMed, Scopus, Portal de Periódicos da Capes e em livros, utilizando as palavras-chave: vitamina C, ácido ascórbico, estresse oxidativo, antioxidante e pró-oxidante. A suplementação com AA é controversa, sendo descrito tanto o seu efeito antioxidante, como o pró-oxidante. A sua efetividade na prevenção e no tratamento do resfriado, diabete e câncer é questionável. Determinados grupos de pessoas mostram-se mais suscetíveis à toxicidade e aos danos do AA, podendo apresentar incidência de cálculos renais e interferência na função plaquetária. Concluímos que a suplementação em doses excessivas de AA pode ocasionar uma transição de um estado saudável para o patológico, desencadeando uma atividade pró-oxidante. Além disso, a dose ótima a ser ingerida e o limiar entre a dose benéfica e a prejudicial, é discutível. Desse modo, a suplementação de vitamina C deve ser realizada com cautela, com prescrição e acompanhamento de profissionais da saúde. Palavras-chave: Antioxidante. Pró-oxidante. Ácido ascórbico. Estresse oxidativo. ABSTRACTVitamin C or ascorbic acid (AA) is an essential element for humans and, because it is not metabolized by the body, we need its intake through diet and / or supplementation. The functions of AA in the body are numerous, such as: cofactor for many enzymes, biosynthesis of hormones, antioxidant action, however, studies report that the consumption of AA in high doses can pose health risks. Thus, we sought to analyze the known and reported effects of AA supplementation. We carried out a bibliographic review, divided into two perspectives: a historical one, with publications of 1753-2012; and a contemporary one, with studies conducted between 1990-2017. The research was conducted in Science Direct, Scielo, PubMed, Scopus, Capes Newspaper Portal, using the keywords: vitamin C, ascorbic acid, oxidative stress, antioxidant and pro-oxidant. Supplementation with AA is controversial, with both antioxidant and prooxidant effects being described. Its effectiveness in the prevention and treatment of colds, diabetes and cancer is questionable. Certain groups of people are more susceptible to the toxicity and damage of AA, with an incidence of renal calculi and interference with platelet function. We can conclude...

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“…The free radical scavenging potential of EO was assessed on the basis of reduction of DPPH (Sigma-Aldrich) according to our previous works. 15,[23][24][25] DPPH (8 mg) was dissolved in chloroform (100 ml) to get a concentration of 80 mcg/ml. The various concentrations of the EO were prepared from stock solution (1mg/ml).…”

Section: Determination Of In-vitro Radical Scavenging Activitymentioning

confidence: 99%

GC-MS Analysis, Antioxidant and Antimicrobial Screening of Volatile Oil of Lepidium vesicarium

et al. 2018

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Background: Lepidium vesicarium (Cruciferae), one of the important medicinal plants with a long history of medicinal use. The current study was designed to evaluate the free radical scavenging and antimicrobial activities of the L. vesicarium EO as one of the Iranian plant species. Methods: The compositions of the EO from the aerial parts of L. vesicarium were analyzed by GC-MS and GC-FID. Furthermore, anti-oxidant and anti-microbial potentials were investigated via DPPH reagent and disk diffusion procedure, respectively. Results: A total of 18 compounds amounting 97.70% of the oil have been identified, while Benzyl cyanide (43.94%), Isothio cyanic acid (22.69%) and Benzyl isothio cyanate (20.69%) were the main constituents. The EO showed no activity against the free radicals and studied microbial strains (gram positive and gram negative and also fungi species). Conclusion: On the whole, the presence of cyanide derivatives in studied EO revealed the rational use of this plant in medicine. Comparing with other genesis of Lepidium, anti-oxidant and anti -microbial properties of L. vesicarium essential oil were not noticeable.

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Vitamins, Are They Safe?

Cited by 61 publications

References 92 publications

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

Os Efeitos Da Suplementação Com Vitamina C

GC-MS Analysis, Antioxidant and Antimicrobial Screening of Volatile Oil of Lepidium vesicarium

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