Vitamins, Vegetables and Metal Elements Are Positively Associated with Breast Milk Oligosaccharide Composition among Mothers in Tianjin, China

Li, Xinyang; Mao, Yingyi; Liu, Shuang; Wang, Jin; Li, Xiang; Zhao, Yanrong; Hill, David R.; Wang, Shuo

doi:10.3390/nu14194131

Cited by 10 publications

(13 citation statements)

References 31 publications

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“…Initially, at 1 month, we observed a positive correlation between zinc and 2′-FL, indicating a potential link between maternal zinc intake and the presence of 2′-FL during early lactation. This observation is consistent with the previous literature emphasizing the role of metals in HMO biosynthesis [ 33 , 34 ]. However, upon considering the longitudinal trajectory of zinc intake, which significantly decreased from 1 month to 12 months postpartum, a different trend emerged.…”

Section: Discussionsupporting

confidence: 94%

“…In a study conducted in China, researchers investigated the correlation between maternal dietary intake and breastmilk human milk oligosaccharide (HMO) concentrations across all lactation periods (0–400 days) among lactating women [ 33 ]. They found that the dietary intake of metal elements was significantly correlated with breastmilk HMO concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Maternal Diet Associated with Oligosaccharide Abundances in Human Milk from Latina Mothers

Mokhtari,

Schmidt,

Zamanian

et al. 2024

Nutrients

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Growing evidence indicates that human milk oligosaccharides (HMOs) are important bioactive compounds that enhance health and developmental outcomes in breastfed babies. Maternal dietary intake likely contributes to variation in HMO composition, but studies identifying diet–HMO relationships are few and inconsistent. This study aimed to investigate how the maternal intake of macronutrients and micronutrients—specifically proteins, fats, vitamins, and minerals—associated with HMOs at 1 month (n = 210), 6 months (n = 131), and 12 months postpartum (n = 84). Several associations between maternal dietary factors and HMO profiles were identified utilizing partial correlation analysis. For example, maternal free sugar (rho = −0.02, p < 0.01), added sugar (rho = −0.22, p < 0.01), and sugary sweetened beverage (rho = −0.22, p < 0.01) intake were negatively correlated with the most abundant HMO, 2′-fucosyllactose (2′-FL), at 1 month, suggesting that higher sugar consumption was associated with reduced levels of 2′-FL. Further, vitamins D, C, K, and the minerals zinc and potassium were positively correlated with 2′-FL at 1 month (pAll < 0.05). For the longitudinal analysis, a mixed-effects linear regression model revealed significant associations between maternal vitamin intake and HMO profiles over time. For example, for each unit increase in niacin intake, there was a 31.355 nmol/mL increase in 2′-FL concentration (p = 0.03). Overall, the results provide additional evidence supporting a role for maternal nutrition in shaping HMO profiles, which may inform future intervention strategies with the potential of improving infant growth and development through optimal HMO levels in mothers’ milk.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Maternal Diet Associated with Oligosaccharide Abundances in Human Milk from Latina Mothers

Mokhtari,

Schmidt,

Zamanian

et al. 2024

Nutrients

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“…In our study, the mean of total concentration of HMOs was consistent with previous reports. For individual HMOs, 2 ′ -FL was the most abundant HMOs in our study, which is also consistent with previous reports [20,39]. However, Zhang et al [40] pointed out that 6 ′ -SL was the most abundant HMO in Chinese mature milk from one-month postpartum.…”

Section: Hmos Concentrationssupporting

confidence: 92%

Patterns of Human Milk Oligosaccharides in Mature Milk Are Associated with Certain Gut Microbiota in Infants

Mao,

Zhao,

Jiang

et al. 2024

Nutrients

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Human milk oligosaccharides (HMOs) are complexes that play a crucial role in shaping the early-life gut microbiota. This study intends to explore whether HMO patterns are associated with the gut microbiota of infants. We included 96 Chinese breastfeeding mother–infant dyads. Breast milk and infant faecal samples were collected and tested. With milk 2′-fucosyllactose, difucosyllactose, and lacto-N-fucopentaose-I as biomarkers, we divided the mothers into secretor and non-secretor groups. HMO patterns were extracted using principal component analysis. The majority (70.7%) of mothers were categorised as secretor and five different HMO patterns were identified. After adjustment, the infants of secretor mothers exhibited a lower relative abundance of Bifidobacterium bifidum (β = −0.245, 95%CI: −0.465~−0.025). An HMO pattern characterised by high levels of 3-fucosyllactose, lacto-N-fucopentaose-III, and lacto-N-neodifucohexaose-II was positively associated with the relative abundance of Bifidobacterium breve (p = 0.014), while the pattern characterised by lacto-N-neotetraose, 6′-sialyllactose, and sialyllacto-N-tetraose-b was negatively associated with Bifidobacterium breve (p = 0.027). The pattern characterised by high levels of monofucosyl-lacto-N-hexaose-III and monofucosyl-lacto-N-neohexaose was positively associated with Bifidobacterium dentium (p = 0.025) and Bifidobacterium bifidum (p < 0.001), respectively. This study suggests that HMO patterns from mature breast milk were associated with certain gut microbiota of breastfed infants.

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“…Seppo et al ( 59 ) demonstrated that the concentrations of 3-FL and 3′-SL were higher in colostrum from mothers in the probiotic supplementation group, whereas difucosyllacto-N-hexaose, LNT, lacto-N-fucopentaose I, and 6′-SL were lower in mothers who received probiotic supplementation relative to a control group. A published study from our team showed that dietary vitamins, vegetables and metal elements are positively associated with HMO concentration using a mixed effect model with lactational stage and secretor status as the random effect ( 60 ). In addition, investigations by Davis et al ( 50 ) revealed that mothers nursing in the dry season produced significantly more total HMOs compared to mothers nursing in the wet season.…”

Section: Discussionmentioning

confidence: 99%

Lactational and geographical variation in the concentration of six oligosaccharides in Chinese breast milk: a multicenter study over 13 months postpartum

Liu,

Mao,

Wang

et al. 2023

Front. Nutr.

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IntroductionUnderstanding the variations of oligosaccharide in breast milk contribute to better study how human milk oligosaccharides (HMOs) play a role in health-promoting benefits in infants.MethodsSix abundant HMOs, 2’-fucosyllactose (2’-FL), 3-fucosyllactose (3-FL), Lacto-N-tetraose (LNT), Lacto-N-neotetraose (LNnT), 3’-sialyllactose (3’-SL) and 6’-sialyllactose (6’-SL), in breast milk collected at 0–5 days, 10–15 days, 40–45 days, 200–240 days, and 300–400 days postpartum from six locations across China were analyzed using high-performance anion-exchange chromatography-pulsed amperometric detector.ResultsThe concentration of individual HMO fluctuated dynamically during lactational stages. The median ranges of 2’-FL, 3-FL, LNT, LNnT, 3’-SL, and 6’-SL across the five lactational stages were 935–2865 mg/L, 206–1325 mg/L, 300–1473 mg/L, 32–317 mg/L, 106–228 mg/L, and 20–616 mg/L, respectively. The prominent variation was observed in the content of 6’-SL, which demonstrates a pattern of initial increase followed by a subsequent decrease. Among the five lactational stages, the transitional milk has the highest concentration, which was 31 times greater than the concentration in mature milk at 300–400 days postpartum, where the content is the lowest. Geographical location also influenced the content of HMOs. LNT and LNnT were the highest in mature milk of mothers from Lanzhou among the six sites at 40–240 days postpartum. Breast milks were categorized into two groups base on the abundance of 2’-FL (high and low). There was no significant difference in the proportions of high and low 2’-FL phenotypes among the six sites, and the percentages of high and low 2’-FL phenotypes were 79% and 21%, respectively, across all sites in China.DiscussionThis study provided a comprehensive dataset on 6 HMOs concentrations in Chinese breast milk during the extended postpartum period across a wide geographic range and stratified by high and low 2’-FL phenotypes.

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Vitamins, Vegetables and Metal Elements Are Positively Associated with Breast Milk Oligosaccharide Composition among Mothers in Tianjin, China

Cited by 10 publications

References 31 publications

Maternal Diet Associated with Oligosaccharide Abundances in Human Milk from Latina Mothers

Maternal Diet Associated with Oligosaccharide Abundances in Human Milk from Latina Mothers

Patterns of Human Milk Oligosaccharides in Mature Milk Are Associated with Certain Gut Microbiota in Infants

Lactational and geographical variation in the concentration of six oligosaccharides in Chinese breast milk: a multicenter study over 13 months postpartum

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