Vitien II: Aortenklappenstenose

Genome clones and expressed sequence tags (ESTs) from the ascidian Ciona intestinalis and from the larvacean Oikopleura dioica were analysed for the presence of lysozyme-encoding genes. Two genes were found to potentially code for goose-type lysozymes in Oikopleura, while three or possibly more g-type proteins form the lysozyme complement of C. intestinalis, and at least one of these genes from each species is expressed based on EST data. No genes for chicken- or invertebrate-type lysozymes were found in either urochordate species. Consistent with this finding, extracts of Oikopleura animals possessed hydrolysing activity on bacterial cell walls, and this activity was not inhibited in the presence of a known inhibitor of chicken-type lysozyme. A wide range of isoelectric points for the predicted lysozymes from Ciona (pI 4.4, 6.4 and 9.9) and from Oikopleura (pI 5.0 and 8.0) suggests tissue-specific adaptations as well as specific functional roles of the lysozymes. Comparisons of gene structures, encoded sequences, cysteine residue content and their positions in the proteins indicate that the g-type lysozymes of Ciona intestinalis are more closely related to those of vertebrates than are the g-type lysozymes of Oikopleura. Multiple genes from each species may result from separate and lineage-specific duplications followed by functional specialisation.

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Urochordates carry multiple genes for goose-type lysozyme and no genes for chicken- or invertebrate-type lysozymes

Nilsen

Myrnes

Edvardsen³

et al. 2003

Cellular and Molecular Life Sciences (CMLS)

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Vascular Access Site Complications after Percutaneous Transfemoral Aortic Valve Implantation

Kahlert

Al–Rashid

Weber

et al. 2009

Herz

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Completely percutaneous TAVI has a high acute success rate with low intraprocedural and 30-day mortality. The patient collective appears to be prone to vascular complications which remain an important limitation of this novel technique. Although conservative or endovascular management is possible in the majority of cases, further technological developments are obliged to reduce the vascular complication rate.

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Kathetergestützte Aortenklappenimplantation aus chirurgischer Sicht

Bleiziffer

Bauernschmitt

Ruge

et al. 2009

Herz

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Vitien II: Aortenklappenstenose

Cited by 5 publications

References 23 publications

Urochordates carry multiple genes for goose-type lysozyme and no genes for chicken- or invertebrate-type lysozymes

Urochordates carry multiple genes for goose-type lysozyme and no genes for chicken- or invertebrate-type lysozymes

Vascular Access Site Complications after Percutaneous Transfemoral Aortic Valve Implantation

Kathetergestützte Aortenklappenimplantation aus chirurgischer Sicht

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