Vitiligo et phénomène de Koebner suite à des injections de plasma riche en plaquettes

Ejjiyar, Mouna; Sahibi, Mehdi; Gueouatri, Mehdi El; Bhihi, Abdelkoddous; Mahrouch, M; Yafi, Imane; Amrani, M.; Benchamkha, Yassine

doi:10.11604/pamj.2019.32.58.16779

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…However, clinicians should be cautious when interpreting the results of these studies which used the combination of a superior mode of therapy with a minor intervention [220]. Furthermore, repeated injections at short intervals are a painful procedure and can induce koebnerization [221]. Further larger RCTs with longer follow-up are required to confirm these findings.…”

Section: Alternative Treatment Optionsmentioning

confidence: 99%

Vitiligo: A Review

2020

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Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5-2% of the population worldwide. The disease is characterized by the selective loss of melanocytes which results in typical nonscaly, chalky-white macules. In recent years, considerable progress has been made in our understanding of the pathogenesis of vitiligo which is now clearly classified as an autoimmune disease. Vitiligo is often dismissed as a cosmetic problem, although its effects can be psychologically devastating, often with a considerable burden on daily life. In 2011, an international consensus classified segmental vitiligo separately from all other forms of vitiligo, and the term vitiligo was defined to designate all forms of nonsegmental vitiligo. This review summarizes the current knowledge on vitiligo and attempts to give an overview of the future in vitiligo treatment.

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Section: Alternative Treatment Optionsmentioning

confidence: 99%

Vitiligo: A Review

2020

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“…14 Ejjiyar et al reported the onset of Koebner's phenomenon in a female patient phototype IV with the onset of facial non-segmental vitiligo after the third injection of PRP, for aesthetic purposes. 17…”

Section: Resultsmentioning

confidence: 99%

<p>The Usefulness of Platelet-Rich Plasma (PRP) for the Treatment of Vitiligo: State of the Art and Review</p>

Mercuri

Vollono

Paolino

2020

DDDT

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Introduction: Vitiligo is an acquired, idiopathic disorder clinically characterized by amelanotic lesions on the skin which cause significant impairment of patients' quality of life. A variety of treatments have been proposed, with inconsistent results. In the last decades, the use of platelet-rich plasma (PRP) is receiving increasing interest as a potential effective technique in the treatment of several dermatological diseases, including vitiligo. Objective: We conducted a review with the aim to identify studies that documented the use of PRP for vitiligo. Materials and Methods: Electronic databases of MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to November 2019 have been searched using different combinations of the following terms: "platelet-rich plasma", "platelet gel", "platelet-rich fibrin", "PRP" and "vitiligo". Results: We identified 6 clinical studies consistent with our research, with a total of 253 patients, listing and discussing the obtained results. In all reports, all treated patients showed a stable vitiligo, and a significantly higher improvement in the PRP groups was always observed compared to control groups. Regarding the side effects, PRP in vitiligo patients is useful and without important side effects. Conclusion: PRP is a promising treatment for stable vitiligo lesions in different body sites. The possible use of PRP in combination with traditional therapeutic options and the standardization of processing protocols represents a very fertile field for future research. Larger clinical trials with longer time of observation would provide solid evidence regarding the effectiveness of PRP for the treatment of vitiligo.

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“…Needle acupuncture [130] Radiotherapy [131][132][133][134][135] Cupping therapy [136,137] Hirudotherapy [138] Specific Immunotherapy [139] Pulsed dye laser [140] Laser hair removal [141,142] Platelet-rich plasma injection [143] Subcutaneous Methotrexate/ Insulin Injection [144][145][146] Purified protein derivative (PPD)/ Mantoux test [31,147,148] Ayurveda [149] Colostomy Bag [150] Hair transplantation/ skin grafting [151,152] Mohs micrographic surgery [111] Electrocardiogram electrode negative pressure suction [153] Secondary to other diseases…”

Section: Vaccination [129]mentioning

confidence: 99%

Characteristics and pathogenesis of Koebner phenomenon

Zhang

Jiang

et al. 2022

Experimental Dermatology

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The Koebner phenomenon, also known as isomorphic reaction, refers to the development of secondary lesions with the same clinical manifestations and histopathological characteristics as the primary lesions in normal skin after trauma or other stimuli. The triggering factors of Koebner phenomenon include physical trauma, chemical stimulation, mechanical stress, iatrogenic stimulation and pathogenic infection. Vitiligo, psoriasis and lichen planus are considered true Koebner phenomenon. Recent studies have shown that immunological disorders, oxidative stress, defective melanocyte adhesion and growth factor deficiency are the main pathological mechanisms of vitiligo Koebner phenomenon. In psoriasis, triggers may drive skin inflammation to induce a psoriatic phenotype through multiple signalling pathways and thereby cause Koebner phenomenon in susceptible individuals. Significantly, keratinocytes mediate the occurrence of Koebner phenomenon in psoriasis through mechano‐induced signalling pathways after sensing mechanical signals and explains the high frequency of psoriasis lesions on the extensor side of the elbow and knee joints. On the contrary, TRPA1‐driven mechano‐transduction, autoimmunity and actinic damage are the underlying mechanisms of Koebner phenomenon in lichen planus. In this review, we have summarized the current understanding of the characteristics and pathogenesis of Koebner phenomenon.

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Vitiligo et phénomène de Koebner suite à des injections de plasma riche en plaquettes

Cited by 5 publications

References 3 publications

Vitiligo: A Review

Vitiligo: A Review

<p>The Usefulness of Platelet-Rich Plasma (PRP) for the Treatment of Vitiligo: State of the Art and Review</p>

Characteristics and pathogenesis of Koebner phenomenon

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