Vitiligo road map

Lee, Brian W.; Schwartz, Robert A.; Hercogová, Jana; Valle, Yan; Lotti, Torello

doi:10.1111/dth.12006

Cited by 23 publications

(24 citation statements)

References 145 publications

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“…Although it is not physically harmful, vitiligo is often psychologically devastating due to the depigmented macules on the skin that result from the selective loss of functional epidermal melanocytes [2418]. Amelanotic melanocytes in the outer root sheath of hair follicles have been shown to migrate towards the achromic epidermis during the process of repigmentation and gradually restore the normal functions of melanin synthesis.…”

Section: Discussionmentioning

confidence: 99%

“…The expression levels of tyrosinase and its related proteins (tyrosinase-related protein 1 and tyrosinase-related protein 2) are mainly regulated by microphthalmia transcription factor (MITF), which is an important regulator of melanocyte differentiation, proliferation and survival and is highly coupled with melanogenesis [1827]. Any therapy for vitiligo must promote not only the repopulation of melanocytes but also melanogenesis and melanocyte migration.…”

Section: Discussionmentioning

confidence: 99%

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Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Chen

Tan

et al. 2017

Korean J Physiol Pharmacol

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Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro. This research aimed to study the ability of pimecrolimus on stimulating melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression. Results showed that pimecrolimus at the dosages of 1, 10, 102 nM were neither mitogenic nor cytotoxic to melanocytes. The addition of pimecrolimus at 10, 102 and 103 nM significantly increased intracellular tyrosinase activity, which was consistent with the elevated content of melanin content at the same concentrations. The peak effect was seen at 72 h in response to 102 nM pimecrolimus. Results of the wound scratch assay and Transwell assays indicate that pimecrolimus is effective in facilitating melanocyte migration on a collagen IV-coated surface. In addition, MITF protein yield reached the highest by pimecrolimus at 102 nM. In brief, pimecrolimus enhances melanin synthesis as well as promotes migration of melanocytes directly, possibly via their effects on MITF protein expression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Chen

Tan

et al. 2017

Korean J Physiol Pharmacol

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“…Keratinocytes supply essential growth factors for melanocyte growth . Keratinocyte‐derived factors like endothelin‐1, stem cell factor ( SCF ), basic fibroblast growth factor ( bFGF ) and nerve growth factor, etc., help in melanogenesis . A mice study has shown that SCF and bFGF should be supplied in the culture medium for the in‐vitro proliferation of melanocyte stem cells .…”

Section: Cellular Transplantation Methodsmentioning

confidence: 99%

Vitiligo surgery: A journey from tissues via cells to the stems!

Afra

Parsad

2018

Experimental Dermatology

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Depigmented patches in vitiligo, a common dermatosis, cause a great psychological distress to the patients. Hence, apart from halting the disease process, the strategies to impart normal skin colour to these white patches carry an important role in the management of vitiligo. Surgical procedures are often required for stable vitiligo lesions not responding to medical therapies. It involves “shuffling” of melanocytes from the pigmented skin to the depigmented areas. During the last fifty years, the vitiligo surgery has evolved from tissue transplantation via cellular transplantation to reach a stage where the use of stem cells or immunomodulatory cells is contemplating. We would like to depict this wonderful journey of vitiligo surgery through this viewpoint.

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“…It occurs clinically by the appearance of well-circumscribed, asymptomatic, white macules following the loss of functional melanocytes in the epidermis (1). The prevalence rate of vitiligo ranges from 0.06% to 2.28% in the population (2).…”

Section: Introductionmentioning

confidence: 99%

“…The main etiopathogenesis of vitiligo is multifactorial. According to various pathophysiological theories, it may be associated with autoimmunity, neurogenic dysregulation, autocytotoxicity, biochemical dysregulation, oxidative stress, and weak melanocyte viability (1,(3)(4)(5)(6). Several potentially environmental factors such as infectious agents appear to be related with vitiligo (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Rifaioğlu¹,

Aydogan²,

Şen³

et al. 2014

Turk J Med Sci

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IntroductionVitiligo is an acquired depigmenting skin disorder. It occurs clinically by the appearance of well-circumscribed, asymptomatic, white macules following the loss of functional melanocytes in the epidermis (1). The prevalence rate of vitiligo ranges from 0.06% to 2.28% in the population (2). The main etiopathogenesis of vitiligo is multifactorial. According to various pathophysiological theories, it may be associated with autoimmunity, neurogenic dysregulation, autocytotoxicity, biochemical dysregulation, oxidative stress, and weak melanocyte viability (1,(3)(4)(5)(6). Several potentially environmental factors such as infectious agents appear to be related with vitiligo (7-9).Helicobacter pylori (HP) is a major health problem affecting about 50% of the world population (10). Gastric ulceration and carcinogenesis are associated with HP infection (11). HP infection has been linked to various autoimmune dermatological diseases, such as alopecia areata, Behçet's disease, chronic urticaria, pruritus, psoriasis, and rosacea (12-17). The frequency of HP has not been studied in patients with vitiligo. Noninvasive tests such as the carbon 13 or carbon 14 (C14) urea breath test (UBT), stool antigen tests, and serology are used to detect HP infection (18). In this study, we used the C14 UBT to detect the frequency of HP infection in patients with vitiligo. Materials and methods Patient and control groupsWith the approval of the local ethics committee, a prospective study was conducted in our dermatology department clinic. The study comprised 34 patients with vitiligo and 30 age-and sex-matched healthy controls. The patients with vitiligo were newly diagnosed and older than 16 years. The patients with gastrointestinal symptoms or those who had received eradication therapy for HP earlier were excluded from the study. Other exclusion criteria were age under 16 years, pregnancy or lactation, and the use of antibiotics, proton pump inhibitors, or H2 blockers in the 40, 7, and 14 days, respectively, leading up to sample collection. According to the working clinical classification, vitiligo was classified as vitiligo vulgaris, acrofacial, focal, segmental, universal, or mucosal (16).Background/aim: Vitiligo is a common, acquired depigmenting skin disorder. The relationship between Helicobacter pylori (HP) infection and autoimmune dermatological disease has been previously reported. However, the frequency of HP infection in patients with vitiligo has not been reported. In this study, we aimed to investigate the frequency of HP infection with the carbon 14 (C14) urea breath test (UBT) in patients with vitiligo. Materials and methods:This study included 34 patients (18 males and 16 females) with vitiligo and 30 age-and sex-matched healthy controls. HP infection was diagnosed using the C14 UBT (Heliprobe). Statistical analysis was performed using SPSS 19. Results:The frequency of HP infection was 64.7% in the patient group and 33.3% in the control group according to the C14 UBT (chisquare test, P = 0.012). HP infection frequ...

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Vitiligo road map

Cited by 23 publications

References 145 publications

Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Vitiligo surgery: A journey from tissues via cells to the stems!

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

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