Vitis amurensis Rupr: A review of chemistry and pharmacology

Chen, Qing; Diao, Lichao; Shi, Hua; Zhu, Xuan

doi:10.1016/j.phymed.2017.08.013

Cited by 36 publications

(36 citation statements)

References 73 publications

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“…Proposed fragmentation pathway of compound 26 is shown in Figure 2. Similar stilbene derivatives were already identified in the genus Vitis [32,33].…”

Section: Resultssupporting

confidence: 72%

Production of Stilbenes in Callus Cultures of the Maltese Indigenous Grapevine Variety, Ġellewża

et al. 2019

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The production of secondary metabolites in tissue culture has been considered as an alternative to the cultivation and harvesting of crops intended for this purpose. The present study was aimed at the growth of callus and production of polyphenolic compound of callus derived from a Maltese indigenous grapevine variety, Ġellewża. Callus was inoculated onto plant growth regulators-enriched Murashige Skoog media (MSm) to determine whether polyphenols are produced in vitro as well as to determine the best combination of plant growth regulators needed for the production of these metabolites. From results obtained, it was observed that the best callus production was obtained by auxin-enriched MSm. In fact, indole acetic acid and indole acetic acid /6-benzyl aminopurine enhanced biomass accumulation (3.04 g and 3.39 g) as opposed to the others (<1.97 g). On the other hand, parameters showing the presence of flavonoids (tonality, 3.80), particularly anthocyanins (24.09 mg/kg) and total polyphenols (1.42 mg/g), were optimum in the presence of cytokinins, particularly 6-benzyl aminopurine. Analysis for single polyphenols revealed a high amount a particular stilbene: polydatin (glucoside of resveratrol). Resveratrol and other typical polyphenols, found in mature berries, were also found in significant quantities, while the other polyphenolic compounds were found in minimal quantities. This is the first study to describe the production and composition of polyphenols in Ġellewża callus cultures. From the results obtained, it can be seen that this grape tissue is an excellent alternative for the production of polyphenols from the stilbene group, which can be upscaled and exploited commercially.

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“…Proposed fragmentation pathway of compound 26 is shown in Figure 2. Similar stilbene derivatives were already identified in the genus Vitis [32,33].…”

Section: Resultssupporting

confidence: 72%

Production of Stilbenes in Callus Cultures of the Maltese Indigenous Grapevine Variety, Ġellewża

et al. 2019

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“…Vitis amurensis Aupr., a species of wild-growing grape originating from east Asian, has been used as a traditional Chinese herb for hundreds of years to treat pain and cancer. Recent studies revealed that roots and stems of V. amurensis possessed antioxidant, anti-inflammatory, antibacterial, and cardioprotective activities and contained various oligomers of resveratrol (Huang et al, 2001; Chen et al, 2018). Resveratrol (3,5,4′-trihydroxy- trans -stilbene) has demonstrated its ability to alleviate inflammation in airway diseases and suppress cigarette smoke (CS)–induced oxidative lung inflammatory injury (Wood et al, 2010; Knobloch et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Amurensin H, a Derivative From Resveratrol, Ameliorates Lipopolysaccharide/Cigarette Smoke–Induced Airway Inflammation by Blocking the Syk/NF-κB Pathway

et al. 2019

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Amurensin H, a resveratrol dimer derived from Vitis amurensis Rupr, has several biological effects, including anti-inflammatory and antioxidant activities. Studies have found that amurensin H attenuated asthma-like allergic airway inflammation. However, its protective activity on chronic obstructive pulmonary disease (COPD) airway inflammation is not fully explored. The present study used a lipopolysaccharide (LPS)/cigarette smoke–induced mice model and an LPS-stimulated THP-1–derived macrophages model to measure the lung tissue’s morphology changes. The results showed that amurensin H ameliorated the histological inflammatory alterations in the lung tissues, leading to a decrease in the expression of interleukin 6 (IL-6), IL-17A, tumor necrosis factor α (TNF-α), and interferon γ in bronchoalveolar lavage fluid. Amurensin H also significantly inhibited the release of IL-1β, IL-6, IL-8, and TNF-α in LPS-stimulated THP-1–derived macrophages. Furthermore, amurensin H markedly inhibited the expressions of p-Syk, nuclear factor κB (NF-κB), and p-NF-κB both in vivo and in vitro. Results from cotreatment with Syk inhibitor BAY61-3606 and NF-κB inhibitor BAY11-7082 in vitro revealed that amurensin H’s protective effect against airway inflammation could be due partly to the inhibition of the Syk/NF-κB pathway. These findings suggest that amurensin H shows therapeutic effects on COPD airway inflammation, and inhibiting the Syk/NF-κB pathway might be part of its underlying mechanisms.

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“…Main phenolic compounds were also analyzed in V. labrusca leaves (Dani et al, 2010;Dresch et al, 2014). Chen et al (2018) reviewed V. amurensis polyphenolic composition and related pharmacological properties. At present, the scientific interest about Vitis sp.…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic diversity in Vitis sp. leaves

Kedrina-Okutan

Novello

Hoffmann

et al. 2019

Scientia Horticulturae

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We identified and quantified the main constitutive polyphenolic compounds of the leaves of seven Vitis species and of one interspecific cross, analysing leaf blades and veins separately, to spread light on the strategic localization of polyphenols in leaf tissues. To the best to our knowledge, the main leaf constitutive polyphenols of V. candicans, V. coignetiae, V. vinifera sylvestris and Börner were never described. V. riparia and V. rupestris (belonging to the same botanical series of Ripariae) displayed similar flavan-3-ol and dimeric proanthocyanidin concentration and similar percentage incidence of caftaric acid over total phenolic acids. V. riparia distinguished respect to the other genotypes for its high flavonol content, the highest percentage incidence of myricetin derivatives and an important diversification in the type of accumulated flavonol. V. berlandieri (series Cinereae) and Börner (hybrid of V. riparia x V. cinerea) accumulated low amounts of flavonol-glucosides comparing to the other species, but they showed a wide profile diversification, as well. However, it was V. v. sylvestris, the wild ancestor of Vitis vinifera subsp. sativa that displayed the widest flavonol profile diversification. The differences in the flavonol profile could be related to the genus Vitis evolution: in fact, with domestication, the flavonoid biosynthetic pathway underwent a progressive simplification; for this, the highest flavonol diversity found in Vitis v. sylvestris is probably a demonstration of its reduced or nil level of domestication. V. amurensis, known for its cold tolerance and resistance to downy mildew, anthracnose and white rot, markedly differentiated respect to the other genotypes, for its high concentration of polyphenols, particularly of vein flavonols and flavanonols. Moreover, V. amurensis leaves generally presented a constantly high concentration of constitutive polyphenols throughout the season that probably contributes to protect against adverse environmental condition. The abundance of polyphenols in V. amurensis leaves emphasizes that this species is a source of natural bioactive compounds that could find application for nutraceutical and pharmacological uses. V. berlandieri and Börner markedly distinguished respect to the other studied species for their exclusive capability to accumulate flavones (mainly orientin, isoorientin, vitexin and isovitexin) in blades and in veins, in considerable amounts.Knowledge about these subjects could contribute to shed light on the identification of speciesrelated molecules involved in the plant-defense mechanisms, to the chemotaxonomy of the genus Vitis, to the possibility of identifying specific natural bioactive compounds to use in plant-based preparation for nutraceutical, cosmetic, feed/food-additive purposes.

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Vitis amurensis Rupr: A review of chemistry and pharmacology

Cited by 36 publications

References 73 publications

Production of Stilbenes in Callus Cultures of the Maltese Indigenous Grapevine Variety, Ġellewża

Production of Stilbenes in Callus Cultures of the Maltese Indigenous Grapevine Variety, Ġellewża

Amurensin H, a Derivative From Resveratrol, Ameliorates Lipopolysaccharide/Cigarette Smoke–Induced Airway Inflammation by Blocking the Syk/NF-κB Pathway

Polyphenolic diversity in Vitis sp. leaves

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