Vitix®– a new treatment for vitiligo?

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

“…Combinations of SOD with or without CAT and other additional compounds (vitamin B12, calcium pantothenate, copper, zinc) were tested in six trials (152 patients). Two studies were placebo controlled, and in one study, betamethasone 0.05% was used as a control . One report using excimer light with Vitiskin hydrogel (SOD, copper–zinc, vitamin B12, calcium pantothenate) did mention more repigmentation (>51% repigmentation in 47% vs. 0% with intra‐individual comparison) after 3 months of therapy while the results of another study using Vitix gel (SOD, CAT) were negative .…”

“…Two studies were placebo controlled, and in one study, betamethasone 0.05% was used as a control. [60][61][62][63][64][65] One report using excimer light with Vitiskin hydrogel (SOD, copper-zinc, vitamin B12, calcium pantothenate) did mention more repigmentation (>51% repigmentation in 47% vs. 0% with intra-individual comparison) after 3 months of therapy while the results of another study using Vitix gel (SOD, CAT) were negative. 62,64 Sanclemente et al 61 did not find a difference between topical CAT + SOD and 0.05% betamethasone.…”

Complementary and Alternative Medicine for Vitiligo

“…Cucumis melo extracts have shown to have vitiligo-relevant superoxide-dismutase and catalase-like activities when used with selective UVB therapy (Kostović et al, 2007). However, it was ineffective in other studies (Schallreuter & Rokos, 2005;Yuksel et al, 2009). "Callumae" is a product which contains Picrorhiza kurroa, khellin, L-phenylalanine, gingko biloba, alpha lipoic acid, cyanocobalamin, pyridoxine and folic acid.…”

The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study

“…It is claimed that this medication can be beneficial for the removal of the H 2 O 2 from the skin and consequently prevents the destruction of the melanocytes. [11] However, there are some controversial results in this case.…”