Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The MONTRACHET Study)

Blanc, Julie; Seydou, Alassane; Ghezala, Inès Ben; Deschasse, C.; Meillon, Cyril; Bron, Alain M.; Binquet, Christine; Creuzot‐Garcher, Catherine

doi:10.1167/iovs.18-26510

Cited by 8 publications

(7 citation statements)

References 55 publications

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“…Following these examinations, they were classified into three levels of evidence according to the ISGEO (International Society for Geographical and Epidemiological Ophthalmology) classification [26]. The OCT results were therefore not taken into account (Foster et al, 2002).The 97.5 and 99.5 percentiles for the vertical cup-to-disc-ratio found in our population defined the limits of the three levels of evidence at 0.7 and 0.8 respectively [27]. In this analysis, only cases of primary open-angle glaucoma were taken into account.…”

Section: Eye Examinationmentioning

confidence: 99%

Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study

et al. 2021

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Background To compare plasma fatty acids (FAs) between participants with primary open-angle glaucoma (POAG) and participants without neuropathy in an elderly population and to investigate specific FAs pattern in POAG. Methods We conducted a population-based study in participants older than 75 years. Participants underwent a comprehensive eye examination with optic nerve photographs, visual field test and optic nerve OCT with RNFL thickness measurement. Glaucomatous status was defined according to the International Society for Epidemiologic and Geographical Ophthalmology classification. Lipids were extracted from plasma and FAs methylesters prepared and analyzed by gas chromatography-mass spectrometry. Results Among the 1153 participants of the Montrachet study 810 were retained for analysis and 68 had POAG. The mean age was 82.11 ± 3.67. In multivariable analysis FAs levels were not different between POAG participants and controls (P = 0.078). A FAs pattern characterized by high negative weight of gamma-linoleic acid, eicosapentaenoic acid polyunsaturated FAs (PUFAs), Cis-7 hexadecenoic acid monounsaturated FAs (MUFAs) and high positive weight of eicosadienoic acid, docosatetraenoic acid, docosapentaenoic n-6, alpha linoleic acid PUFAs, eicosenoic acid MUFAs, margaric acid and behenic acid saturated FAs was positively associated with POAG. After adjustment for major confounders, individuals in the upper tertile of FAs pattern scores compared with those in the lower tertile were more likely to present POAG (OR = 3.09 [95% CI 1.29–7.40] P = 0.013). Conclusions We found no significant difference regarding isolated plasma FAs between participants with POAG and participants without neuropathy in elderly but specific FAs pattern might be associated with POAG.

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Section: Eye Examinationmentioning

confidence: 99%

Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study

et al. 2021

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“…The information given by macular thickness is very limited in our study since the software used did not provide any detailed inner retinal segmentation at the time of the study. Moreover, since we reported a high prevalence of vitreomacular abnormalities (up to 54% in glaucoma patients) in the same cohort, using SD-OCT macular parameters for glaucoma diagnosis in the elderly is debatable (Blanc et al, 2019).…”

Section: Discussionmentioning

confidence: 98%

“…To determine the three levels of evidence described by Foster et al, we used the 97.5th and 99.5th percentiles for the vertical cup-to-disc-ratio found in our population-based study. The 97.5 and 99.5 percentiles for the vertical cup-todisc-ratio and vertical cup-to-disc-ratio asymmetry were 0.7, 0.2 and 0.8, 0.3, respectively (Blanc et al, 2019). Only cases of primary open-angle glaucoma were considered for the present analysis.…”

Section: Classification Of Glaucomamentioning

confidence: 99%

Diagnostic ability of spectral‐domain optical coherence tomography peripapillary retinal nerve fiber layer thickness to discriminate glaucoma patients from controls in an elderly population (The MONTRACHET study)

Arnould

Lazzer

Seydou

et al. 2020

Acta Ophthalmologica

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Purpose To evaluate the capacity of retinal nerve fibre layer (RNFL) thickness measured by SD‐OCT to discriminate glaucoma patients from controls in an elderly population. Methods The MONTRACHET (Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases) Study is a population‐based study including participants aged 75 years and over. All participants underwent a complete eye examination with optic nerve photographs, visual field testing and OCT peripapillary RNFL thickness measurement. Glaucoma was defined according to the ISGEO (International Society for Epidemiologic and Geographical Ophthalmology) classification. Performance indicators were calculated including area under the receiver operating characteristics curves (AUC), likelihood ratios (LR) and diagnostic odds ratios (DOR). Results In total, 1061 participants were included in the study, of whom 89 were classified as having glaucoma and 972 were classified as normal. The mean (SD) age of the population was 82.3 (3.7) years. The average RNFL thickness was significantly lower in the glaucoma group than in controls 64.0 (14.9) µm versus 88.9 (12.4) µm, respectively, p < 0.001) and in all sectors compared with controls. The average RNFL thickness had the highest AUC (0.901) followed by the temporal‐inferior (0.879) and temporal‐superior sectors (0.862). When RNFL thickness was classified as abnormal by SD‐OCT, the average RNFL thickness had the best sensitivity (83.75%) followed by the temporal‐inferior sector (75.64%). The specificity for these two parameters was 87.34% and 91.08%, respectively. The highest DOR was 28.70 for average RNFL thickness and reached 34.84 when using the reference database of the OCT manufacturer. Conclusion This study confirms that SD‐OCT could be useful as an additional test to discriminate glaucoma patients from controls in an elderly population.

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“…We found a higher prevalence of glaucoma in ERM eyes. By using optical coherence tomography (OCT) among subjects older than 75 years old, the prevalence of ERM was found to be higher in eyes with glaucoma than without glaucoma [27]. Prevalence of a retinal nerve fiber layer defect (RNFLD) was higher in eyes with ERM than without ERM, while optic disc cupping was equivalent between with and without ERM.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan

Shimizu

Asaoka

Fujishiro

et al. 2021

Life

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The prevalence of an epiretinal membrane (ERM) was elucidated using a dataset from a health examination program database in Japan. From the cohort database, 5042 eyes of 2552 subjects were included. The presence of an ERM, cellophane macular reflex (CMR), or preretinal macular fibrosis (PMF) was detected using color fundus photographs, and crude and age-standardized prevalence were obtained. To further assess the possible risk factors of ERM, background parameters were compared between ERM+ and − groups, and multiple logistic regression analysis was performed. ERM was detected in fundus photographs of 275 eyes (eye-based prevalence of 5.5%) from 217 subjects (subject-based prevalence of 8.5%). CMR was detected in 169 eyes (3.4%) of 138 subjects (5.4%), and PMF was detected in 106 eyes (2.1%) of 97 subjects (3.8%). By univariate analyses, compared with ERM− eyes or subjects, higher Scheie’s H grade (p < 0.0001), S grade (p < 0.0001), and glaucoma prevalence (p = 0.0440) were found in ERM+ eyes, and older age (p < 0.0001), more frequent histories of hypertension (p = 0.0033) and hyperlipidemia (p = 0.0441), and more frequent uses of medication for hypertension (p = 0.0034) and hyperlipidemia (p = 0.0074), shorter body height (p = 0.0122), and higher systolic blood pressure (p = 0.0078), and thicker intimal medial thickness (p = 0.0318) were found in ERM+ subjects. By multivariate analyses, older age (p < 0.0001, estimate = 0.05/year) was the only significant factor of ERM prevalence. Age-standardized prevalence of ERM was calculated to be 2.4%, 6.7%, and 13.3% for all ages, subjects older than 40 years, and subjects older than 65 years, respectively. We reported the prevalence of ERM and its subclasses in Japanese subjects. Since its prevalence is remarkably high in older subjects, an ERM can be seen as an important cause of visual impairment in Japan and in areas of the world where individuals live to an advanced age.

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Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The MONTRACHET Study)

Cited by 8 publications

References 55 publications

Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study

Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study

Diagnostic ability of spectral‐domain optical coherence tomography peripapillary retinal nerve fiber layer thickness to discriminate glaucoma patients from controls in an elderly population (The MONTRACHET study)

Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan

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