Vitreoretinal Surgery for Severe Retinal Capillary Hemangiomas in Von Hippel–Lindau Disease

Von Hippel-Lindau Disease: A Genetic and Clinical Review

“…Rarely, surgical excision may be performed for severe cases, but a high rate of recurrences and complications has been reported. 49 The primary goal of treatment is to prevent further growth of the lesions, which can lead to vision loss due to tractional retinal detachment, exudation, hemorrhage, glaucoma, and cataract. 10,50 Well-timed early treatments are effective in preserving vision and preventing blindness.…”

Imaging of retinal and choroidal vascular tumours

“…It is important to identify retinal haemangioblastomas and their associated complications at an early stage as advanced lesions are not usually controlled with conventional laser-or cryotherapy alone. 7 These large lesions are usually accompanied by severe exudative and vitreoretinal traction. Such advanced disease often results in a blind and painful eye, necessitating enucleation in about 10% of patients.…”

“…1,2 In addition to conventional radiotherapy, cryotherapy, and laser photocoagulation, new therapeutical options include anti-VEGF pharmacotherapy, proton beam radiotherapy, photodynamic therapy, and small gauge vitrectomy. [3][4][5][6][7][8] These have been reviewed elsewhere and are therefore not discussed in the present article.…”

Massive Exudative Retinal Detachment After Photodynamic Therapy for Peripheral Retinal Capillary Hemangioma

“…Various therapeutic modalities such as laser photocoagulation, cryotherapy, and vitreoretinal surgery have been reported, with varying and limited success depending on the tumor characteristics. 1,2 Although smalland medium-sized RCHs can be treated effectively with laser photocoagulation, cryotherapy, or a combination of both, large and multiple RCHs are often refractory to these conventional treatments. Pars plana vitrectomy with or without direct dissection of such large and multiple RCHs has been considered as the secondary treatment of choice.…”

“…However, serious vision-threatening complications related to surgery, such as proliferative vitreoretinopathy and tumor recurrence, have been reported. 2 Recently, several less invasive alternatives have been used to treat challenging cases, including photodynamic therapy (PDT) with verteporfin 3-6 and intravitreal injection of anti-vascular endothelial growth factor. 7 Of these, PDT has had dramatic anatomical and functional success for treating peripheral RCH, resulting not only in regression of tumor activity but also in maintenance of the visual acuity with limited complications.…”