Vitreous Attachment in Age-Related Macular Degeneration, Diabetic Macular Edema, and Retinal Vein Occlusion

Jackson, Timothy L.; Nicod, Elena; Angelis, Aris; Grimaccia, Federico; Prevost, A. Toby; Simpson, Andrew; Kanavos, Panos

doi:10.1097/iae.0b013e31828991d6

Cited by 66 publications

(53 citation statements)

References 42 publications

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“…This warrants further evaluation as OCT has greatly improved our understanding of how the vitreoretinal interface is related to pathology such as vitreomacular traction 14 and AMD. 15,16 In a study comparing standard OCT to faster (100,000 A-scans/sec) longer wavelength ss-OCT imaging, Sayanagi et al 12 imaged 79 eyes with polypoidal choroidal vasculopathy (PCV) and 63 eyes with AMD and found their prototype ss-OCT with longer wavelength improved visualization of the choroidal-scleral interface and improved definition of some pathologic findings compared with Spectralis SD-OCT without EDI. There are several differences, however, from our study in that our graders were masked, we compared the longer wavelength scans to 870 nm with EDI (while the majority of their lower wavelength scans were without EDI), and we studied vitreous at the vitreoretinal interface, not just presence of epiretinal membrane.…”

Section: Discussionmentioning

confidence: 99%

Retinal and Choroidal Imaging With 870-nm Spectral-Domain OCT Compared With 1050-nm Spectral-Domain OCT, With and Without Enhanced Depth Imaging

Verner-Cole

Campbell

Hwang

et al. 2014

Trans. Vis. Sci. Tech.

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Purpose: The purpose of this study was to compare images of the retina and choroid obtained with Spectralis 1050-nm spectral-domain optical coherence tomography (SD-OCT) with and without enhanced depth imaging (EDI) to the commercially available 870-nm SD-OCT with and without EDI.Methods: Full-length 308 line scans were obtained with both 870-and 1050-nm Spectralis OCT instruments, with and without EDI. Two trained retina physicians masked to wavelength and EDI status assessed the ability to visualize the vitreoretinal interface and full-thickness choroid, and subfoveal choroidal thickness (SFCT) was measured.Results: Included in the study were 21 eyes. The vitreoretinal interface was visualized best with 870-nm OCT without EDI and was diminished with 1050-nm OCT. Graders preferred 1050 nm with EDI over 870 nm with EDI in qualitative comparisons of the choroid; 1050 nm without EDI was slightly preferred over 870 nm with EDI but was not statistically significant. SFCT measurements correlated well among the imaging modalities except for 870 nm without EDI.Conclusions: SD-OCT with EDI at 870 nm provides good visualization of both the vitreoretinal interface and choroid, whereas 1050-nm SD-OCT with or without EDI provides more choroidal detail at the expense of visualization of the vitreoretinal interface.

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Section: Discussionmentioning

confidence: 99%

Retinal and Choroidal Imaging With 870-nm Spectral-Domain OCT Compared With 1050-nm Spectral-Domain OCT, With and Without Enhanced Depth Imaging

Verner-Cole

Campbell

Hwang

et al. 2014

Trans. Vis. Sci. Tech.

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“…PVD might be expected to enhance the diffusion of endogenous VEGF away from the macula, and if PVD increases oxygenation this would also tend to lower macular VEGF levels. In addition, VMA may be associated with VMT that can in itself cause macular edema, which is a hallmark of all three diseases and a major cause of vision loss [66] .…”

Section: Discussionmentioning

confidence: 99%

Review and Perspectives on Pharmacological Vitreolysis

Bandello¹,

Spina²,

Iuliano³

et al. 2013

Ophthalmologica

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The vitreous is involved in multiple diseases when an incomplete posterior vitreous detachment (PVD) occurs. An incomplete PVD can lead to several pathological conditions. Such visually threatening conditions are traditionally of exclusive surgical interest. In contrast, pharmacological vitreolysis is the effort to reduce or eliminate the pathogenetic role of the vitreous solely by means of drug delivery. Here we aim to review and summarize the evidence available to date about this challenging new approach.

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“…ОКТ произвела революцию в клинической практике офтальмологии. Это неинвазивный метод визуализа-ции, который позволяет получить изображения в виде срезов сетчатки, слоя нервных волокон и зрительного нерва [4,5,6].…”

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Analysis of the central zone of the retina in patients with diabetic macular edema

et al. 2015

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Структурно-функциональный анализ центральной зоны сетчатки у пациентов с диабетическим макулярным отекомБикбов М.М., Файзрахманов Р.Р., Ярмухаметова А.Л., Зайнуллин Р.М. ГБУ Уфимский НИИ глазных болезней АН РБ, УфаОдним из наиболее значимых проявлений сахарного диабета является поражение сетчатки в виде диабетического макулярного отека (ДМО)

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Vitreous Attachment in Age-Related Macular Degeneration, Diabetic Macular Edema, and Retinal Vein Occlusion

Abstract: Observational studies of sufficient quality indicate that eyes with wet AMD have double the expected prevalence of vitreomacular adhesion and are less likely to have a posterior vitreous detachment. More controlled studies of diabetic macular edema and retinal vein occlusion are needed.

Cited by 66 publications

References 42 publications

Retinal and Choroidal Imaging With 870-nm Spectral-Domain OCT Compared With 1050-nm Spectral-Domain OCT, With and Without Enhanced Depth Imaging

Retinal and Choroidal Imaging With 870-nm Spectral-Domain OCT Compared With 1050-nm Spectral-Domain OCT, With and Without Enhanced Depth Imaging

Review and Perspectives on Pharmacological Vitreolysis

Analysis of the central zone of the retina in patients with diabetic macular edema

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