VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

Ruby, Maxwell A.; Goldenson, Benjamin; Orasanu, Gabriela; Johnston, Thomas P.; Plutzky, Jorge; Krauss, Ronald M.

doi:10.1194/jlr.m005561

Cited by 62 publications

(54 citation statements)

References 37 publications

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“…Fatty acids derived from fatty-acid synthase (41) or intracellular (42) and extracellular lipolysis (43) can activate PPAR␣ in the liver, whereas lipoprotein lipase is a source of PPAR␣ ligands in the heart (44). Extracellular fatty acids are also a source of ligands for PPAR␦ in ␤-cells (45) and the liver (46).…”

Section: Discussionmentioning

confidence: 99%

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

Mottillo

Bloch

Leff

et al. 2012

Journal of Biological Chemistry

173

165

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Background: Adrenergic activation of brown adipocytes mobilizes fatty acids for oxidation and promotes transcription of oxidative genes. Results: Activation of adipocyte lipases generates agonists of PPAR␣ and PPAR␦ that promote transcription of oxidative genes. Conclusion: Lipolytic products signal via PPAR␣ and PPAR␦. Significance: Lipolytic activation of PPAR␣ and PPAR␦ provides a mechanism for matching oxidative capacity to substrate supply.

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Section: Discussionmentioning

confidence: 99%

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

Mottillo

Bloch

Leff

et al. 2012

Journal of Biological Chemistry

173

165

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“…Similarly, the enzyme that locally hydrolyzes triglyceride-rich lipoproteins and releases fatty acids, lipoprotein lipase, was shown to generate PPAR␣-activating species in these cells (33). Addition of albumin abrogated the PPAR␣ activation, which implicates protein binding of the lipoprotein lipasegenerated fatty acids as an important factor (34). Another phospholipid-related species, oleoylethanolamide (OEA), was shown to regulate feeding and body weight through PPAR␣ activation.…”

Section: Ppar␣mentioning

confidence: 99%

Endogenous Ligands for Nuclear Receptors: Digging Deeper

Schupp

Lazar

2010

Journal of Biological Chemistry

155

120

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Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs through the identification of their endogenous ligands is a key element for our understanding of their biology. In this minireview, we give an update on recent progress in regard to endogenous ligands for a cluster of NRs with high sequence homology, namely peroxisome proliferator-activated receptors ␣ and ␥, Rev-erb␣, and related receptors. This knowledge about the nature and physiology of these ligands may create new opportunities for therapeutic drug development.

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“…158 ApoCIII, an endogenous inhibitor of LPL activity, can modulate PPAR␣ activation. 159 PPAR␥ can also promote EPC generation. 160 GPIHBP1, a PPAR␥-regulated endothelial protein, is a cofactor for LPL activity, whereas endothelial PPAR␥ deficiency protects against diet-induced obesity while causing a marked dyslipidemia.…”

Section: Peroxisome Proliferator-activated Receptor ␥mentioning

confidence: 99%

The PPAR-RXR Transcriptional Complex in the Vasculature

Plutzky

2011

Circulation Research

Self Cite

137

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Key Words: atherosclerosis Ⅲ diabetes Ⅲ PPARs Ⅲ RXRs Ⅲ gene expression E nergy balance is a fundamental necessity and, as such, is relevant to many disciplines. In physics, energy balance considers energy flow and transformation across different states. Engineering studies energy balance in closed systems, like an automobile, and the distance traveled for the fuel consumed. In geophysics, the energy required to extract a fuel from the earth is set against the energy that fuel yields. For nations and their economies, the energy available is balanced against rates of consumption and cost. Arguably, biology provides the most fundamental context for energy balance: survival, which is predicated on obtaining, using, and storing energy resources. From this perspective, it is striking that the increasingly prevalent chronic diseases facing industrial countries, namely obesity, diabetes, dyslipidemia, and atherosclerosis, are either characterized or defined by abnormalities of energy resources.Original

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VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

Cited by 62 publications

References 37 publications

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

Endogenous Ligands for Nuclear Receptors: Digging Deeper

The PPAR-RXR Transcriptional Complex in the Vasculature

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