1997
DOI: 10.1097/00000542-199703000-00023
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Volatile Anesthetics Protect the Ischemic Rabbit Myocardium from Infarction

Abstract: The volatile anesthetics tested protected the ischemic rabbit heart from infarction, in contrast to the three intravenous agents tested. Protection was independent of the hypotensive effect of the inhalational agents because halothane also protected isolated hearts, in which changing vascular tone is not an issue and coronary perfusion pressure is constant. Cardioprotection by volatile anesthetics depended on both adenosine receptors and protein kinase C, and thus is similar to the mechanism of protection seen… Show more

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Cited by 288 publications
(157 citation statements)
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“…*P \ 0.05, **P \ 0.01 vs. sham group; P \ 0.05, P \ 0.01 vs. CON group; à P \ 0.05, but another report demonstrated that pentobarbital did not increase the extent of infarction in rabbits. 20 It could be disputed that the anesthetic protocol using sodium pentobarbital might have influenced our results, however, we showed that emulsified isoflurane could successfully execute a cardioprotective effect in the presence of sodium pentobarbital. Furthermore, identical anesthetic protocols were adopted in our study; thus, it is logical to consider that pentobarbital was not capable of producing different influences on parameters measured among groups.…”
Section: Discussionmentioning
confidence: 64%
“…*P \ 0.05, **P \ 0.01 vs. sham group; P \ 0.05, P \ 0.01 vs. CON group; à P \ 0.05, but another report demonstrated that pentobarbital did not increase the extent of infarction in rabbits. 20 It could be disputed that the anesthetic protocol using sodium pentobarbital might have influenced our results, however, we showed that emulsified isoflurane could successfully execute a cardioprotective effect in the presence of sodium pentobarbital. Furthermore, identical anesthetic protocols were adopted in our study; thus, it is logical to consider that pentobarbital was not capable of producing different influences on parameters measured among groups.…”
Section: Discussionmentioning
confidence: 64%
“…7,9,10 There are only a few studies directly comparing general anesthesia with isoflurane and propofol during a period of ischemia/reperfusion. 8,36 One such study assessed the red blood cell (RBC) antioxidant capacity of isoflurane and clinical low-and high-dose propofol. They found high-dose propofol (200 µg·kg -1 ·min -1 ) resulted in enhanced RBC antioxidant capacity, suggesting that high-dose propofol anesthesia could increase the threshold for oxidative injury during ischemia/reperfusion.…”
Section: Infarct Ratiomentioning
confidence: 99%
“…They determined that isoflurane protected the reperfused ischemic rabbit heart from infarction to a greater extent than propofol. 8 They used an in vivo rabbit model, with a 30-min occlusion followed by three hours of reperfusion. Normalized myocardial necrosis was significantly lower in the isoflurane group.…”
Section: Infarct Ratiomentioning
confidence: 99%
See 1 more Smart Citation
“…(61) These and other studies suggest that isoflurane either directly activates A1 receptors or indirectly enhances the sensitivity of A1-receptors to reduced amounts of endogenously released adenosine. (62) This protection could be reversed by adenosine receptor antagonists, by Gi protein blockers, PKC inhibitors, and K ATP channel blockers. Therefore, it may be assumed that inhalational anesthetics could stimulate these receptors, proteins and signal transduction pathways including the K ATP channels.…”
mentioning
confidence: 99%