Volatile Organic Compounds as Potential Biomarkers for Noninvasive Disease Detection by Nanosensors: A Comprehensive Review

Velusamy, Palaniyandi; Su, Chia‐Hung; Ramasamy, Palaniappan; Viswanathan, Arun; Rajnish, K. Narayanan; Pachaiappan, Raman; Vaseeharan, Baskaralingam; Kumar, Sakkarapalayam Murugesan Senthil; Gopinath, Subash C. B.

doi:10.1080/10408347.2022.2043145

Cited by 22 publications

(4 citation statements)

References 120 publications

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“…Due to methodological constraints, auxiliary diagnosis has limitations [8], such as low sensitivity or specificity, invasive examination, long time, etc. Pathological diagnosis also relies on accurate sampling and high professionalism [11]. Therefore, it is necessary to develop convenient, efficient, and accurate diagnostic methods.…”

Section: Introductionmentioning

confidence: 99%

Volatolomics in healthcare and its advanced detection technology

Jian

et al. 2022

Nano Res.

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Various diseases increasingly challenge the health status and life quality of human beings. Volatolome emitted from patients has been considered as a potential family of markers, volatolomics, for diagnosis/screening. There are two fundamental issues of volatolomics in healthcare. On one hand, the solid relationship between the volatolome and specific diseases needs to be clarified and verified. On the other hand, effective methods should be explored for the precise detection of volatolome. Several comprehensive review articles had been published in this field. However, a timely and systematical summary and elaboration is still desired. In this review article, the research methodology of volatolomics in healthcare is critically considered and given out, at first. Then, the sets of volatolome according to specific diseases through different body sources and the analytical instruments for their identifications are systematically summarized. Thirdly, the advanced electronic nose and photonic nose technologies for volatile organic compounds (VOCs) detection are well introduced. The existed obstacles and future perspectives are deeply thought and discussed. This article could give a good guidance to researchers in this interdisciplinary field, not only understanding the cutting-edge detection technologies for doctors (medicinal background), but also making reference to clarify the choice of aimed VOCs during the sensor research for chemists, materials scientists, electronics engineers, etc.

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Section: Introductionmentioning

confidence: 99%

Volatolomics in healthcare and its advanced detection technology

Jian

et al. 2022

Nano Res.

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“…A challenging approach in electronic nose development is to design custom-based sensor arrays applying nanomaterial-based technologies. Nanotechnology provides the opportunity to design individual sensors that are specific to certain molecules [ 278 , 279 ]. This allows for the tailoring of unique detector systems by including sensors in the array that are sensitive to VOC molecules, which have been identified with GC/MS techniques to have a good discriminative power in the diagnosis of certain diseases [ 249 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 ] ( Table 4 ).…”

Section: Breathomics—breath Fingerprintingmentioning

confidence: 99%

Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics

et al. 2023

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Cancers, chronic diseases and respiratory infections are major causes of mortality and present diagnostic and therapeutic challenges for health care. There is an unmet medical need for non-invasive, easy-to-use biomarkers for the early diagnosis, phenotyping, predicting and monitoring of the therapeutic responses of these disorders. Exhaled breath sampling is an attractive choice that has gained attention in recent years. Exhaled nitric oxide measurement used as a predictive biomarker of the response to anti-eosinophil therapy in severe asthma has paved the way for other exhaled breath biomarkers. Advances in laser and nanosensor technologies and spectrometry together with widespread use of algorithms and artificial intelligence have facilitated research on volatile organic compounds and artificial olfaction systems to develop new exhaled biomarkers. We aim to provide an overview of the recent advances in and challenges of exhaled biomarker measurements with an emphasis on the applicability of their measurement as a non-invasive, point-of-care diagnostic and monitoring tool.

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“…Interestingly, ammonia (NH 3 ) is used in various fields such as food, industrial, cleaning, and chemical manufacturing 30 – 32 . Moreover, ammonia has also been utilized as a key signal in the detection of conditions including diabetes, renal illness, malignant tumors, and lung cancer since it is a metabolite in human life 33 .…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of novel chitosan-salicylaldehyde polymer composites for ammonia sensing

Saeed,

Taha,

Dardeer

et al. 2024

Sci Rep

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Chitosan (Chs)-salicylaldehyde (Sal) polymer derivatives were formed via the reaction of Chs-Sal with zinc oxide nanoparticles (ZnO NPs) and beta-cyclodextrin (β-CD). These polymers were synthesized through inclusion with β-CD and doping with ZnO NPs to give pseudopolyrotaxane and Chs-Sal/ZnO NPs composite, respectively, for low-temperature detection and sensing of NH3 vapors as great significance in environmental control and human health. Additionally, the polymer (Chs-Sal/β-CD/ZnO NPs) was prepared via the insertion of generated composite (Chs-Sal/ZnO NPs) through β-cyclodextrin ring. The structural and morphological characterizations of the synthesized derivatives were confirmed by utilizing FTIR, XRD and, SEM, respectively. Also, the optical properties and thermal gravimetric analysis (TGA) of the synthesized polymers were explored. The obtained results confirmed that using β-CD or ZnO NPs for modification of polymer (Chs-Sal) dramatically enhanced thermal stability and optical features of the synthesized polymers. Investigations on the NH3-sensing properties of Chs-Sal/β-CD/ZnO NPs composite were carried out at concentrations down to 10 ppm and good response and recovery times (650 s and 350 s, respectively) at room temperature (RT) and indicated that modification by β-CD and doping with ZnO NPs effectively improves the NH3-sensing response of Chs-Sal from 712 to 6192 using Chs-Sal/β-CD/ZnO NPs, respectively, with low LOD and LOQ of 0.12 and 0.4 ppb, respectively.

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Volatile Organic Compounds as Potential Biomarkers for Noninvasive Disease Detection by Nanosensors: A Comprehensive Review

Cited by 22 publications

References 120 publications

Volatolomics in healthcare and its advanced detection technology

Volatolomics in healthcare and its advanced detection technology

Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics

One-pot synthesis of novel chitosan-salicylaldehyde polymer composites for ammonia sensing

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