Volatile organic compounds exposure associated with depression among U.S. adults: Results from NHANES 2011–2020

Tang, Liwei; Liu, Min; Tian, Jing

doi:10.1016/j.chemosphere.2023.140690

Cited by 13 publications

(9 citation statements)

References 72 publications

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“…Finally, we assessed the relationship between co-exposure to mixed blood VOCs and OAB risk through weighted quantile sum (WQS) regression model after adjusting for all covariates. The WQS is a novel regression model that estimates the overall impact of environmental chemical mixtures on disease-related health outcomes for specific diseases through empirically weighted indices for specific chemicals, which can help identify potentially toxic substances ( 9 , 21 ). In this study, WQS regression was used to assess the overall co-exposure correlations and the contribution weights of each blood VOCs component for the effect of the nine blood VOCs on OAB risk.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a study of 2011–2020 National Health Survey data found that exposure to VOCs may increase the risk of depression. VOCs, including acrylonitrile, toluene, styrene, acrylamide, 1,3-butadiene, and xylene, may be associated with an increased risk of depression through damage to the nervous system ( 9 ). Excessive exposure to benzene compounds, such as toluene, xylene and styrene, can lead to neurocognitive impairment and central nervous system disorders ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, individual VOC exposure levels can be assessed by measuring blood and urine levels of VOCs and their metabolites ( 8 ). A growing body of research suggests that exposure to VOCs is associated with a variety of health disorders, including respiratory, neurological disorders, and diabetes ( 3 , 9 , 10 ). In fact, VOCs can not only be directly absorbed by the human body, resulting in health hazards, but can also be converted into high-activity volatile substances through chemical reactions, facilitating the formation of photochemical smog, exacerbating environmental pollution, and further harming human health ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

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The exposure to volatile organic compounds associate positively with overactive bladder risk in U.S. adults: a cross-sectional study of 2007–2020 NHANES

Zhang,

Yan,

et al. 2024

Front. Public Health

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ObjectiveThe aim of this study was to comprehensively investigate the potential relationship between blood volatile organic compounds (VOCs) and overactive bladder (OAB) risk.MethodsA total of 11,183 participants from the 2007–2020 National Health and Nutrition Examination Survey (NHANES) were included in this cross-sectional study. We used multivariate logistic regression models to investigate the relationship between nine blood VOCs and OAB risk. Restricted cubic spline (RCS) analysis was used to investigate the dose-response relationship between blood VOCs and OAB. In addition, the overall association of blood VOCs with OAB risk was assessed by weighted quantile sum (WQS) regression model. Finally, we conducted subgroup analyses to explore the findings in different high-risk populations.ResultsAfter adjusting for potential confounders, logistic regression analysis revealed that blood 2,5-dimethylfuran (aOR = 2.940, 95% CI: 1.096–7.890, P = 0.032), benzene (aOR = 1.460, 95% CI: 1.044–2.043, P = 0.027) and furan (aOR = 9.426, 95% CI: 1.421–62.500, P = 0.020) were positively independent associated with the risk of OAB. And dose-response risk curves indicated that 2,5-dimethylfuran, benzene and furan in the blood were linearly positive associated with OAB risk. WQS regression analysis showed that exposure to mixed blood VOCs increased the risk of OAB (OR = 1.29, 95% CI: 1.11–1.49), with furans having the greatest weight. In subgroup analyses, we found that OAB was more susceptible to blood VOCs in young and middle-aged, male, non-hypertensive, and alcohol-drinking populations.ConclusionsThe results of this study indicate that high exposure to VOCs is independently and positively associated with OAB risk in U.S. adults, particularly 2,5-dimethylfuran, benzene, and furan. In addition, age, gender, hypertension and alcohol consumption may influence the association. Our study provided novel epidemiologic evidence to explore the potential role of environmental pollutants in OAB.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The exposure to volatile organic compounds associate positively with overactive bladder risk in U.S. adults: a cross-sectional study of 2007–2020 NHANES

Zhang,

Yan,

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…Finally, we assessed the relationship between co-exposure to mixed blood VOCs and OAB risk through weighted quantile sum (WQS) regression model after adjusting for all covariates. The WQS is a novel regression model that estimates the overall impact of environmental chemical mixtures on disease-related health outcomes for specific diseases through empirically weighted indices for specific chemicals, which can help identify potentially toxic substances (9,21). In this study, WQS regression was used to assess the overall co-exposure correlations and the contribution weights of each blood VOCs component for the effect of the nine blood VOCs on OAB risk.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a study of 2011-2020 National Health Survey data found that exposure to VOCs may increase the risk of depression. VOCs, including acrylonitrile, toluene, styrene, acrylamide, 1,3-butadiene, and xylene, may be associated with an increased risk of depression through damage to the nervous system (9). Excessive exposure to benzene compounds, such as toluene, xylene and styrene, can lead to neurocognitive impairment and central nervous system disorders (34,35).…”

Section: Figurementioning

confidence: 99%