“…Ion channels could be classified on the basis of gating, i.e., type of stimuli responsible for their opening and closing. Electrical gradient across the plasma membrane are responsible for the Introductory Chapter: Ion Channels http://dx.doi.org/10.5772/intechopen.80597 opening and closing of voltage-gated ion channels [25,26]; however, binding of the ligands to the channels is responsible for the activation and deactivation of ligand-gated ion channels [29].…”