Voltarol: Diclofenac Sodium

Fowler, P. D.

doi:10.1016/s0307-742x(21)00079-5

Cited by 31 publications

(4 citation statements)

References 21 publications

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“…A similar proportion of those who increased their dose of ibuprofen to 2400mg per day benefited compared to those continuing the original dose of 1600mg per day. In osteoarthritis, other studies have found the effective daily dose of diclofenac to be between 75mg and 150mg (Fowler 1979). The usually recommended dose of ibuprofen is 1600mg per day (Kantor 1979) and Adams and Buckler (1979) report 900 to 1200mg per day as effective in osteoarthritis.…”

Section: Discussionmentioning

confidence: 99%

“…Diclofenac and ibuprofen are anti‐inflammatory drugs which are effective in the treatment of osteoarthritis (Fowler 1979, Kantor 1979). When compared in patients with osteoarthritis Rossi and Baroni (1975) reported a significantly greater improvement with diclofenac but Siegmeth and Sieberer (1978) found no significant difference between them in the treatment of patients with lumbar spondylosis.…”

Section: Introductionmentioning

confidence: 99%

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A Study of the Efficacy and Tolerability of Diclofenac and Ibuprofen in Osteoarthritis of the Hip

Crook

Fowler

Hothersall

et al. 1981

Int J Clinical Practice

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A double blind between patient double dummy study is reported comparing diclofenac and ibuprofen in 47 patients with osteoarthritis affecting the hip. Most patients had severe disease as seen radiologically and were either awaiting surgery or receiving physiotherapy. Ten patients were withdrawn from the study. Changes in clinical assessments were small with no significant differences between the drugs. There was a similar incidence of side effects most being gastrointestinal. Thirteen of 20 patients taking ibuprofen had their dosage increased from 1.6 to 2.40 per day and 6 of 17 patients taking diclofenac had their dose increased from 100 to 150mg per day due to lack of improvement. The study showed no difference in the efficacy or tolerability of diclofenac or ibuprofen in this group of patients with severe disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Study of the Efficacy and Tolerability of Diclofenac and Ibuprofen in Osteoarthritis of the Hip

Crook

Fowler

Hothersall

et al. 1981

Int J Clinical Practice

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“…Diclofenac appears to be a good choice for analgesia in nursing women. (43) The drugs Ibuprofen, Diclofenac,Indomethacin & naproxen have an acceptably low infants dose & are considered safe to use.Aspirin is contraindicated only because of the theoretical risk ofReye,s syndrome .BothParacetamol and codeine are safe alternatives, although combination containing codeine 30 mg should be used cautiously. ( 44)…”

Section: Effects Of Diclofenac On Lactation and Breastmilkmentioning

confidence: 99%

A Review on Diclofenac Sodium: Pharmacological Properties and Recent Advancements

-¹,

-²,

-³

2023

IJFMR

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“…As far as we could find, there have been only four reports on acetaminophen concentrations in breast milk since 1980 [ 13 – 16 ]. There were also only three reports since 1970 on mammary transfer of diclofenac sodium, which is often administered similarly to acetaminophen [ 17 – 19 ]. Most of these were case reports.…”

Section: Introductionmentioning

confidence: 99%

Breast milk concentrations of acetaminophen and diclofenac - unexpectedly high mammary transfer of the general-purpose drug acetaminophen

Tamaki,

Noshiro,

Furugen

et al. 2024

BMC Pregnancy Childbirth

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Background Breastfeeding is considered to be the most effective way of ensuring the health and survival of newborns. However, mammary transfer of drugs administered to mothers to breastfeeding infants remains a pressing concern. Acetaminophen and diclofenac sodium are widely prescribed analgesics for postpartum pain relief, but there have been few recent reports on the mammary transfer of these drugs, despite advances in analytic techniques. Methods We conducted a study on 20 postpartum mothers from August 2019–March 2020. Blood and milk samples from participants were analyzed using liquid chromatography-electrospray ionization tandem mass spectrometry within 24 hours after oral administration of acetaminophen and diclofenac sodium. The area under the concentration-time curve (AUC) was calculated from the concentration curve obtained by a naive pooled-data approach. Results For acetaminophen, AUC was 36,053 ng/mL.h and 37,768 ng/mL.h in plasma and breast milk, respectively, with a milk-to-plasma drug concentration ratio of 1.048. For diclofenac, the AUC was 0.227 ng/mL.h and 0.021 ng/mL.h, in plasma and breast milk, respectively, with a milk-to-plasma drug concentration ratio of 0.093. Conclusions While diclofenac sodium showed low mammary transfer, acetaminophen showed a relatively high milk-to-plasma drug concentration ratio. Given recent studies suggesting potential connections between acetaminophen use during pregnancy and risks to developmental prognosis in children, we believe that adequate information regarding the fact that acetaminophen is easily transferred to breast milk should be provided to mothers.

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Voltarol: Diclofenac Sodium

Cited by 31 publications

References 21 publications

A Study of the Efficacy and Tolerability of Diclofenac and Ibuprofen in Osteoarthritis of the Hip

A Study of the Efficacy and Tolerability of Diclofenac and Ibuprofen in Osteoarthritis of the Hip

A Review on Diclofenac Sodium: Pharmacological Properties and Recent Advancements

Breast milk concentrations of acetaminophen and diclofenac - unexpectedly high mammary transfer of the general-purpose drug acetaminophen

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