Voluntary Corn Oil Ingestion Increases Energy Expenditure and Interscapular UCP1 Expression Through the Sympathetic Nerve in C57BL/6 Mice

Matsumura, Shigenobu; Ishikawa, Fuka; Sasaki, Tsutomu; Odanaka, Mayuki; Manio, Mark Christian C.; Fushiki, Tohru; Inoue, Kazuo

doi:10.1002/mnfr.201800241

Cited by 5 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9). A very recent study with another feeding model arrived at a similar conclusion (51). We find it likely that the nervous system is not only necessary for recruitment of BAT but that it is indeed neuronal stimulation that induces and regulates the recruitment process, but this principally cannot be concluded from these type of experiments.…”

Section: Discussionsupporting

confidence: 59%

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

Fischer

Schlein

Cannon

et al. 2019

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

The possibility that recruitment and activation of brown adipose tissue (BAT) thermogenesis could be beneficial for curtailing obesity development in humans prompts a need for a better understanding of the control of these processes [that are often referred to collectively as diet-induced thermogenesis (DIT)]. Dietary conditions are associated with large changes in blood-borne factors that could be responsible for BAT recruitment, but BAT is also innervated by the sympathetic nervous system. To examine the significance of the innervation for DIT recruitment, we surgically denervated the largest BAT depot, i.e., the interscapular BAT depot in mice and exposed the mice at thermoneutrality to a high-fat diet versus a chow diet. Denervation led to an alteration in feeding pattern but did not lead to enhanced obesity, but obesity was achieved with a lower food intake, as denervation increased metabolic efficiency. Conclusively, denervation totally abolished the diet-induced increase in total UCP1 protein levels observed in the intact mice, whereas basal UCP1 expression was not dependent on innervation. The denervation of interscapular BAT did not discernably hyper-recruit other BAT depots, and no UCP1 protein could be detected in the principally browning-competent inguinal white adipose tissue depot under any of the examined conditions. We conclude that intact innervation is essential for diet-induced thermogenesis and that circulating factors cannot by themselves initiate recruitment of brown adipose tissue under obesogenic conditions. Therefore, the processes that link food intake and energy storage to activation of the nervous system are those of significance for the further understanding of diet-induced thermogenesis.

show abstract

Section: Discussionsupporting

confidence: 59%

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

Fischer

Schlein

Cannon

et al. 2019

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Thermogenesis is induced in response to cold [ 17 ] and high fat diet (HFD) feeding [ [18] , [19] , [20] ]; both are dependent on the sympathetic nervous system (SNS) [ 17 , [21] , [22] , [23] ]. SNS tone onto BAT is programmed in response to T r [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Rearing mice at 22°C programs increased capacity to respond to chronic exposure to cold but not high fat diet

Neri

Ramos‐Lobo

Lee

et al. 2023

Molecular Metabolism

View full text Add to dashboard Cite

Dietary flaxseed oil induces production of adiponectin in visceral fat and prevents obesity in mice

Seike,

Ashida,

Yamashita

2024

Nutrition Research

View full text Add to dashboard Cite

Voluntary Corn Oil Ingestion Increases Energy Expenditure and Interscapular UCP1 Expression Through the Sympathetic Nerve in C57BL/6 Mice

Abstract: The present data suggest that corn oil ingestion activates IBAT through the sympathetic nerve, upregulating UCP1 expression and increasing energy expenditure.

Cited by 5 publications

References 43 publications

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

Rearing mice at 22°C programs increased capacity to respond to chronic exposure to cold but not high fat diet

Dietary flaxseed oil induces production of adiponectin in visceral fat and prevents obesity in mice

Contact Info

Product

Resources

About