Von Willebrand Factor and Factor VIII Levels in Egyptian Children With Newly Diagnosed Acute Lymphoblastic Leukemia in Relation to Peripheral Blast Cells and Steroid Therapy

Sherif, Nayera H.K. El; Narouz, Marian F. G.; Elkerdany, Tahany A.; Habashy, Safinaz A. El

doi:10.1097/mph.0000000000000219

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…9 Several studies have shown elevated plasma vWF-Ag levels in both hematologic and non-hematologic malignancies. [10][11][12] Thus vWF-Ag may also serve as a negative prognostic marker for neoplastic disorders.…”

Section: Introductionmentioning

confidence: 99%

von Willebrand Factor Antigen Predicts Outcomes in Patients after Liver Resection of Hepatocellular Carcinoma

Schwarz¹,

Fitschek²,

Mittlböck

et al. 2020

Gut and Liver

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Background/Aims: von Willebrand factor antigen (vWF-Ag) is a noninvasive predictor of portal hypertension that serves as a negative prognostic marker in various malignancies. Increased portal hypertension is associated with higher postoperative morbidity and decreased survival after hepatectomy. The purpose of this study was to determine the correlation between vWF-Ag, postoperative morbidity and oncological outcome. Methods: This analysis includes 55 patients who underwent liver resection for hepatocellular carcinoma (HCC) between 2008 and 2015 with available preoperative vWF-Ag levels. The primary endpoints were postoperative complications and long-term outcome, including overall and diseasefree survival. Results: The median plasma level of vWF-Ag was 191% (range, 162.5% to 277%). There was a significant correlation between vWF-Ag levels and tumor size in the resected specimens (p=0.010, r=0.350). Patients who developed any grade of postoperative complication had significantly higher preoperative vWF-Ag levels (216% [range, 178% to 283.25%] vs 176% [range, 148% to 246%], p=0.041). Median overall survival was 39.8 months in patients with high vWF-Ag levels (≥191%) compared with 73.4 months in patients with low levels (<191%, p=0.007). Of note, there was a remarkable disparity in the number of patients who died of HCC with low versus high vWF-Ag levels (14.8% vs 28.6%, p=0.011). Conclusions: vWF-Ag may serve as a prognostic marker for the outcome of patients undergoing liver resection for HCC that is closely connected to tumor size, postoperative complication rate and long-term outcome.

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Section: Introductionmentioning

confidence: 99%

von Willebrand Factor Antigen Predicts Outcomes in Patients after Liver Resection of Hepatocellular Carcinoma

Schwarz¹,

Fitschek²,

Mittlböck

et al. 2020

Gut and Liver

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von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of osteosarcoma cells in vitro

Liu

Wang

et al. 2018

Bioscience Reports

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von Willebrand factor (vWF) is a major procoagulant molecule that was shown to differentiate between metastatic and primary osteosarcoma (OS) tissues and associated with increased metastasis. However, its functional role in OS progression has been unclear yet. The expression profile of vWF and miR-24 in human OS tissues was characterized using immunofluorescence labeling and quantitative real-time PCR analysis. The interaction between miR-24 and vWF was identified by dual luciferase reporter assay. The effects of vWF and miR-24 on OS cells were assessed by cell proliferation, colony formation, and migration. The clinical significance of miR-24 in OS patients was analyzed using Kaplan–Meier analyses and Pearson’s Chi-squared test. Here, we reported that the expression of vWF was significantly increased, but miR-24 was significantly decreased in OS tissues (n=84). vWF was further validated as the target of miR-24 in MG-63 and U2OS cells. miR-24 obviously suppressed the proliferation and migration of MG-63 and U2OS cells. However, the migration-inhibiting activity of miR-24 was predominantly attenuated by vWF overexpression. Clinically, low miR-24 expression in human OS tissues was significantly associated with tumor metastasis and predicted a poor survival in OS patients. This work demonstrated that vWF, as a downstream effector of miR-24, played an important role in controlling OS cell progression. Target miR-24 or vWF, therefore, promises to be an effective biological target for OS treatment.

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Von Willebrand factor and cancer; metastasis and coagulopathies

Patmore

Dhami

O’Sullivan

2020

Journal of Thrombosis and Haemostasis

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Von Willebrand factor (VWF) is a complex multimeric plasma glycoprotein critical for normal hemostatic function. VWF has two main roles in hemostasis: first, to recruit and tether platelets at sites of vascular injury, facilitating platelet aggregation. Second, VWF acts as a protective carrier molecule for procoagulant factor VIII (FVIII). 1 Under physiological conditions VWF biosynthesis is restricted to endothelial cells (EC) and megakaryocytes. Within ECs, VWF can be constitutively secreted from both the luminal and abluminal membrane or stored in specialized organelles known as Weibel-Palade bodies (WPB). In contrast, platelets store VWF in α-granules, which is released upon activation. 2 Within plasma, mature VWF circulates as a series of large heterogeneous multimers composed of repeating monomeric units, up

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Von Willebrand Factor and Factor VIII Levels in Egyptian Children With Newly Diagnosed Acute Lymphoblastic Leukemia in Relation to Peripheral Blast Cells and Steroid Therapy

Abstract: Markers of endothelial dysfunction namely VWF and FVIII were related to circulating blast cells and steroids therapy through lysis of lymphoblasts results in reduction of both factors, with risk of thrombosis during induction with marked disintegration of malignant cells.

Cited by 3 publications

References 31 publications

von Willebrand Factor Antigen Predicts Outcomes in Patients after Liver Resection of Hepatocellular Carcinoma

von Willebrand Factor Antigen Predicts Outcomes in Patients after Liver Resection of Hepatocellular Carcinoma

von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of osteosarcoma cells in vitro

Von Willebrand factor and cancer; metastasis and coagulopathies

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