Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension

Mura, Vincenzo La; Reverter, Juan Carlos; Flores-Arroyo, A; Raffa, S.; Reverter, Enric; Seijó, Susana; Abraldes, Juan G.; Bosch, Jaime; García‐Pagán, Juan Carlos

doi:10.1136/gut.2010.235689

Cited by 156 publications

(175 citation statements)

References 35 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…It is obvious that there is a strong correlation between hepatocellular failure and vWF Ag level in cirrhosis and synthesis function of liver is negatively correlated with vWF [17,18]. Strength of the statistical significance in our study supports these findings.…”

Section: Discussionsupporting

confidence: 81%

Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis

Yılmaz

Dinçer

Avcı

et al. 2015

EAJM

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 81%

Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis

Yılmaz

Dinçer

Avcı

et al. 2015

EAJM

View full text Add to dashboard Cite

show abstract

“…In cirrhosis, endothelial dysfunction has been surmised by the observation of changes in levels of nitric oxide-derived by-products [61,62], flow mediated vasodilatory response of the brachial artery [63] and VWF levels [64][65][66][67][68]. Currently, there is no single marker that can detect endothelial dysfunction in patients with cirrhosis.…”

Section: Factors Tipping the Hemostatic Balance In Cirrhosismentioning

confidence: 99%

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

Andriulli

Tripodi

Angeli

et al. 2016

Digestive and Liver Disease

View full text Add to dashboard Cite

a b s t r a c tPatients with cirrhosis present with hemostatic alterations secondary to reduced availability of procoagulant and anti-coagulant factors. The net effect of these changes is a rebalanced hemostatic system. The Italian Association of the Study of the Liver (AISF) and the Italian Society of Internal Medicine (SIMI) promoted a consensus conference on the hemostatic balance in patients with cirrhosis. The consensus process started with the review of the literature by a scientific board of experts and ended with a formal consensus meeting in Rome in December 2014. The statements were graded according to quality of evidence and strength of recommendations, and approved by an independent jury. The statements presented here highlight strengths and weaknesses of current laboratory tests to assess bleeding and thrombotic risk in cirrhotic patients, the pathophysiology of hemostatic perturbations in this condition, and outline the optimal management of bleeding and thrombosis in patients with liver cirrhosis.

show abstract

“…Endotoxemia activates endothelial cells and is well correlated with the levels of serum VWF Ag [30] . In 42 cirrhotic patients with severe portal hypertension (HVPG ≥ 12 mmHg), the team from Barcelona has shown a positive correlation between serum VWF Ag and MELD score (r = 0.34, P = 0.032), and between serum VWF Ag and HVPG (r = 0.47, P < 0.001) [31] . However, given the small sample size and the inclusion of patients with HVPG ≥ 12 mmHg, the prognostic value of VWF Ag could not be determined convincingly.…”

Section: Antigenmentioning

confidence: 99%

New prognostic markers in liver cirrhosis

Martino¹

2015

WJH

View full text Add to dashboard Cite

Determining the prognosis of cirrhotic patients is not an easy task. Prognostic scores, like Child-Pugh and Model of End-stage Liver Disease scores, are commonly used by hepatologists, but do not always reflect superimposed events that may strongly influence the prognosis. Among them, bacterial intestinal translocation is a key phenomenon for the development of cirrhosis-related complications. Several biological variables (C-reactive protein, serum free cortisol, copeptin, von Willebrand factor antigen) are surrogates of "inflammatory stress" and have recently been identified as potential prognostic markers in cirrhotic patients. Most of these above mentioned markers were investigated in pilot studies with sometimes a modest sample size but allow us to catch a glimpse of the pathophysiological mechanisms leading to the worsening of cirrhosis. These new data should generate further well-designed studies to better assess the benefit for liver function of preventing intestinal bacterial translocation and microvascular thrombosis. The control of infection is vital and among all actors of immunity, vitamin D also appears to act as an anti-infective agent and therefore has probably a prognostic value.

show abstract

Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension

Abstract: In patients with cirrhosis and portal hypertension vWF levels correlate with liver function and HVPG and independently predict clinical outcome.

Cited by 156 publications

References 35 publications

Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis

Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

New prognostic markers in liver cirrhosis

Contact Info

Product

Resources

About