Von Willebrand Syndromes and Mitral-Valve Prolapse

Pickering, Nancy J.; Brody, Jerome I.; Barrett, Michael J.

doi:10.1056/nejm198107163050303

Cited by 70 publications

(26 citation statements)

References 33 publications

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“…1 ' "• 16 A linked mesenchymal dysplasia involving platelets and collagen of the mitral valve has been postulated. 17 An embolic mechanism for the cause of MVP-associated stroke is supported by angiographic evidence. 13 Valvular thrombi forming on the abnormal valves presumably constitute the typical embolus.…”

Section: Mitral Valve Prolapse and Cerebral Infarctionmentioning

confidence: 98%

Mitral valve prolapse and cerebral infarction.

Hart¹,

Easton²

1982

Stroke

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Section: Mitral Valve Prolapse and Cerebral Infarctionmentioning

confidence: 98%

Mitral valve prolapse and cerebral infarction.

Hart¹,

Easton²

1982

Stroke

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“…This association of primary MVP with an increased incidence in patients with von Willebrand disease and other coagulopathies, primary hypomastia, and various connective tissue diseases has been used to support this concept. 39,40) Grahame, et al reported that there was a trend towards a positive correlation between anterior mitral leaflet excursion (eg, displacement of anterior mitral leaflet) and hypermobility score but this did not reach statistical significance (r = 0.23, P > 0.05). 7) Moreover, they did not study the relationship between MLD, DMR IAOS and AOD and BHS.…”

Section: )mentioning

confidence: 99%

The Relationship Between Echocardiographic Features of Mitral Valve and Elastic Properties of Aortic Wall and Beighton Hypermobility Score in Patients With Mitral Valve Prolapse

et al. 2004

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SUMMARYThe present study was designed to investigate the incidence of benign joint hypermobility syndrome (BJHMS) in mitral valve prolapse (MVP) and the correlation between the echocardiographic features of the mitral valve and elastic properties of the aortic wall and Beighton hypermobility score (BHS) in patients with MVP and BJHMS.Fourty-six patients with nonrheumatic, uncomplicated, and isolated mitral anterior leaflet prolapse (7 men and 39 women, mean age; 26.1 ± 5.9) and 25 healthy subjects (3 men and 22 women, mean age, 25.4 ± 4.3) were studied. Patients were divided into two groups according to their BHS (group I, MVP+BJHMS; group II, MVP-BJHMS). Individuals with accompanying cardiac or systemic disease were excluded. Echocardiographic examination was performed in all subjects. The presence of BJHMS was evaluated according to Beighton's criteria.The incidence of BJHMS in patients with MVP was found to be significantly higher than that of controls (45.6%, (21/46) vs 12% (3/25), P < 0.0001). Group I (MVP + BJHMS) had significantly increased anterior mitral leaflet thickness (AMLT, 3.4 ± 0.4 vs 3.1 ± 0.3; P < 0.005), maximal leaflet displacement (MLD, 2.4 ± 0.4 vs 1.7 ± 0.4; P < 0.005), and degree of mitral regurgitation (DMR, 17.1 ± 7.2 vs 11.2 ± 4.4; P < 0.01) compared to group II. However, the index of aortic stiffness (IAOS) was found to be lower (17.6 ± 6.9 vs 23.9 ± 7.6; P < 0.005) and aortic distensibility (AOD) to be higher (0.0035 ± 0.007 vs 0.0024 ± 0.005; P < 0.005) in group I. There was a significant correlation between AMLT, MLD and DMR, and BHS (r = 0.57/P = 0.007, r = 0.55/P < 0.009, r = 0.51/P < 0.01, respectively). In addition, AOD correlated positively with BHS (r = 0.53/ P < 0.005), but the index of aortic stiffness correlated inversely with BHS (r = -0.49/P < 0.007).The incidence of BJHMS in patients with MVP was more frequent than the normal population and there was a significant correlation between the severity of BJHMS From the

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“…In searching for an explanation of this associa tion, a common autoimmune etiology was suggested as only Graves' disease was associ ated with the cardiac abnormality while thy rotoxicosis of nonimmune origin showed an incidence similar to that of the normal pop ulation. Mitral valve prolapse has been found in association with other diseases such as Marfan's syndrome [3], osteogenesis im perfecta [4], Ehlers-Danlos syndrome [5], pseudoxanthoma elasticum [6] and others [7,8],…”

mentioning

confidence: 99%

Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

Brauman¹,

Rosenberg²,

Gilboa³

et al. 1988

Cardiology

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An increased prevalence of mitral valve prolapse has been found in Graves’ disease and a common autoimmune etiology has been suggested for both disorders. We investigated the prevalence of mitral valve prolapse in 87 patients with autoimmune chronic lymphocytic thyroiditis, 50 patients with nongoitrous hypothyroidism and 111 healthy control subjects. Mitral valve prolapse was found in 16.09% of patients with chronic lymphocytic thyroiditis compared to 6 and 5.4% in nongoitrous hypothyroidism and normal controls, respectively. The result is statistically significant, p < 0.02, and confirms that the prevalence of mitral valve prolapse is significantly increased in patients with autoimmune disorders of the thyroid gland, when compared to normals and nonautoimmune conditions.

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Von Willebrand Syndromes and Mitral-Valve Prolapse

Cited by 70 publications

References 33 publications

Mitral valve prolapse and cerebral infarction.

Mitral valve prolapse and cerebral infarction.

The Relationship Between Echocardiographic Features of Mitral Valve and Elastic Properties of Aortic Wall and Beighton Hypermobility Score in Patients With Mitral Valve Prolapse

Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

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