Voriconazole and sertaconazole loaded colloidal nano-carriers for enhanced skin deposition and improved topical fungal treatment

Qurt, Moammal; Esentürk, İmren; Tan, Seher Birteksöz; Erdal, Meryem Sedef; Araman, Ahmet; Güngör, Sevgi

doi:10.1016/j.jddst.2018.09.020

Cited by 19 publications

(11 citation statements)

References 38 publications

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“…Also, fluorescence intensity of skin applied on Nile Red-loaded microemulsion was more intense than those of the skin applied on PBS suspension (Figure 6a, b). This phenomenon demonstrated that ME3 microemulsion increased cutaneous uptake and permeation of lipophilic molecules into the skin compared to PBS suspension as also reported in a previous study [34,40]. Moreover, the confocal images were consistent with the results of in vitro permeation studies.…”

Section: Resultssupporting

confidence: 90%

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Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

Saribey¹,

Kahraman²,

Erdal³

et al. 2021

jrp

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The aim of this work was to develop colloidal nanocarriers for skin delivery of etodolac (ETD), which is a non-steroidal anti-inflammatory drug orally used for the management of acute pain and inflammation, but leads to unfavourable effects on the stomach. The oleic acid and blend of Labrasol/Trancutol P were used as oil phase and surfactant/co-surfactant mixture in the microemulsion formulations, respectively. ETD loaded microemulsions selecting the microemulsion region of pseudo-ternary phase diagrams were prepared, and then the microemulsions were characterised to confirm formation of oil in water microemulsions via optical isotropy, refractive index, droplet size, electrical conductivity, rheological behaviour and morphological analysis. In vitro permeation of ETD through porcine skin was evaluated using Franz diffusion cells for stable ETD loaded microemulsions. ATR-FTIR spectroscopy analysis was performed to elucidate interaction between the microemulsion components and stratum corneum structure on the molecular level. Confocal laser scanning microscopy analysis was further carried out to visualize skin penetration enhancement effect of the microemulsion formulation consisting of a model lipophilic fluorescent marker, Nile Red. The results indicated that the developed microemulsion formulation consisting of oleic acid, Labrasol, Transcutol P and water offer a potential approach to enhance skin delivery of ETD for topical treatment of inflammatory diseases.

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Section: Resultssupporting

confidence: 90%

“…Skin permeation of ETD was examined using Franz type diffusion cells (diffusion area of 1.77 cm 2 , Permegear V6A Stirrer, Hellertown, PA, USA) [40]. The skin was placed on the receiver chambers with the stratum corneum facing upwards and then the donor chambers were clamped in place.…”

Section: Permeation Of Etd Though the Skinmentioning

confidence: 99%

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

Saribey¹,

Kahraman²,

Erdal³

et al. 2021

jrp

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“…In addition, ceramide V in non-lesionedparts of the skin were raised, and ceramide I and ceramide III were reduced in lesioned parts of the skin [40,41]. Moreover, the metabolism pathways such as ceramidase are overactive in the epidermis with atopic dermatitis [42]. Besides, Chermprapai et al [43] determined that free fatty acids were reduced as well as CERs in the atopic dermatitis.…”

Section: Role Of Ceramides In the Skin Barrier And Skin Disordersmentioning

confidence: 99%

“…Psoriasis: In another skin disorder in which barrier defects occurs, Motta et al [42] revealed the relation between ceramide composition and TEWL in psoriatic and healthy skin. According to results, ceramide I, III, IV, V, and VI reduced TEWL increased in all psoriatic scales.…”

Section: Role Of Ceramides In the Skin Barrier And Skin Disordersmentioning

confidence: 99%

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

et al. 2019

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Human skin is the largest organ of the body and is an effective physical barrier keeping it from environmental conditions. This barrier function of the skin is based on stratum corneum, located in the uppermost skin. Stratum corneum has corneocytes surrounded by multilamellar lipid membranes which are composed of cholesterol, free fatty acids and ceramides (CERs). Alterations in ceramide content of the stratum corneum are associated with numerous skin disorders. In recent years, CERs have been incorporated into conventional and novel carrier systems with the purpose of exogenously applying CERs to help the barrier function of the skin. This review provides an overview of the structure, function and importance of CERs to restore the barrier function of the skin following their topical application.

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“…Serving as a local (isolated) drug depot and providing a mechanism for controlled release, such systems can deliver high topical concentrations of drugs without pronounced systemic spread [54]. Thus, systems such as polymeric films [55], nano- and microemulsions [56], vesicular carriers [57] (including liposomes [58], ethosomes [59], transethosomes [60], and niosomes [61]), solid lipid [62] and polymeric particles [63], and porous inorganic carriers [64, 65] were proposed and investigated for antifungal agents’ penetration promotion.…”

Section: Nanocarriers For Intradermal Permeation and Antimycotic Actimentioning

confidence: 99%

Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

Lengert¹,

Тальникова²,

Tuchin³

et al. 2020

Skin Pharmacol Physiol

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Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of antifungal drugs is an important aspect here. The present overview is focused on novel nano-based formulations served to improve antimycotic penetration through the skin. Furthermore, it summarizes various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area.

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Voriconazole and sertaconazole loaded colloidal nano-carriers for enhanced skin deposition and improved topical fungal treatment

Cited by 19 publications

References 38 publications

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

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